2004
DOI: 10.1111/j.1365-2249.2004.02649.x
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Early up-regulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model

Abstract: SUMMARYWe investigated cytokine profiles in interleukin (IL)-4 transgenic (Tg) mice with a skin inflammatory disease resembling human atopic dermatitis. cDNA microarray revealed that the mRNAs encoding IL-1 b , IL-2, IL-3, IL-4, IL-5, IL-6, IL-10, IL-12p40, IL-13, tumour necrosis factor (TNF)-a , TNF-b and interferon (IFN)-g were up-regulated in the skin of late lesion Tg mice and to a lesser degree in nonlesion Tg mice when compared to those of non-Tg mice. Real time reverse transcription-polymerase chain rea… Show more

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Cited by 134 publications
(159 citation statements)
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“…The differentiation of Th cells is determined by a complex interplay between multiple factors such as antigen type and dose, dendritic cells, the T-cell receptor, co-stimulatory signals and the cytokine microenvironment as well as apoptotic regulators. [1][2][3][4][5][6][7] DNA microarray studies have described hundreds of differentially expressed genes in CD4 þ T cells stimulated by cytokines, 8,9 taken from transgenic mice, 10 or from peripheral blood of patients with atopic dermatitis. 11 These findings indicate that the proliferation of Th2 cells depends on multiple, interacting genes.…”
Section: Introductionmentioning
confidence: 99%
“…The differentiation of Th cells is determined by a complex interplay between multiple factors such as antigen type and dose, dendritic cells, the T-cell receptor, co-stimulatory signals and the cytokine microenvironment as well as apoptotic regulators. [1][2][3][4][5][6][7] DNA microarray studies have described hundreds of differentially expressed genes in CD4 þ T cells stimulated by cytokines, 8,9 taken from transgenic mice, 10 or from peripheral blood of patients with atopic dermatitis. 11 These findings indicate that the proliferation of Th2 cells depends on multiple, interacting genes.…”
Section: Introductionmentioning
confidence: 99%
“…An epidermal IL-4etrans-genic mouse model was developed that closely resembles human AD clinically, histopathologically, serologically, bacteriologically, and immunologically. [138][139][140][141] The dermal blood vessels in this mouse model show changes consistent with angiogenesis, including elongation, sprouting, and intussusception. 142 Chen et al 143 recently noted a progressive increase in blood vessel number, diameter, and percent dermal area occupied by CD31 1 and VEGFR2 vessels as the disease evolves from start to a chronic state.…”
Section: Rosaceamentioning
confidence: 74%
“…Expression of Th2-type cytokines (IL-5, IL-13), Th1-type cytokines (IL-12p40, IFN-), and inflammatory cytokines (TNF-, IL-1 ) is upregulated in the skin lesions of these mice. Enhancement of these cytokines except IL12p40 is even observed in the skin, before the disease onset or in the intact skin (17). Correspondingly, serum levels of IgE and IgG1 are elevated even before the onset, which reflects high expression of IL-4 and IL-13.…”
Section: Il-4 Transgenic Micementioning
confidence: 80%
“…Chan's group established and characterized IL-4 transgenic mice in which expression of IL-4 is controlled under the promoter of the keratin 14 gene (16)(17)(18)(19). These mice are normal when they are newborn.…”
Section: Il-4 Transgenic Micementioning
confidence: 99%