Early treatment with antibiotics reduces the need for surgery in acute necrotizing pancreatitis—a single-center randomized study

Nordback, Isto; Sand, Juhani; Saaristo, Rauni; Paajanen, Hannu

doi:10.1016/s1091-255x(01)80021-4

Cited by 176 publications

(100 citation statements)

References 14 publications

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“…None showed a convincing decrease in mortality. There have been two meta-analyses: one (184) evaluated three of these studies (112,114,120) and a fourth that was published in German; the other (185) evaluated two studies (112,120) and the same article published in German. The conclusion reached in one (185) was that antibiotic prophylaxis significantly reduced mortality, and in the other that antibiotics reduced pancreatic infection (184).…”

Section: Level Of Evidence: IIImentioning

confidence: 99%

Practice Guidelines in Acute Pancreatitis

Banks

Freeman

2006

Am J Gastroenterology

1,619

947

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Section: Level Of Evidence: IIImentioning

confidence: 99%

Practice Guidelines in Acute Pancreatitis

Banks

Freeman

2006

Am J Gastroenterology

1,619

947

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“…There have been some reports published regarding the prophylactic use of antibiotics for severe pancreatitis [15][16][17][18][19][20][21][22][23][24][25][26] . The ef cacy of prophylactic antibiotics for acute pancreatitis was rst reported after the introduction of carbapenem antibiotics in the 1990s, including a report regarding the use of imipenem by Pederzoli et al 15 .…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Continuous Regional Arterial Infusion with Doripenem and Protease Inhibitors for Severe Acute Pancreatitis

Yamamiya

Kitamura

Ishii

et al. 2015

Showa Univ J Med Sci

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: Doripenem DRPM is a relatively new drug belonging to the carbapenem antibiotic group. We hypothesized that the pharmacological characteristics of DRPM could make it useful in the treatment of severe acute pancreatitis SAP . We investigated the usefulness of continuous regional arterial infusion CRAI with DRPM and protease inhibitors for SAP. Two hundred and forty-two patients with SAP were admitted to Showa University Hospital between November 2002 and June 2013. Of these, 53 patients were treated with CRAI with carbapenem antibiotics and nafamostat mesilate NM , a serine protease inhibitor, via the celiac and superior mesenteric arteries. Clinical outcomes were evaluated retrospectively in 34 patients treated with DRPM and 19 patients undergoing non-DRPM therapy meropenem n 11, imipenem n 6 ; biapenem n 2 . The median time to commencement of oral intake was significantly shorter in the DRPM than non-DRPM group 9 vs 14 hospital days, respectively ; P 0.01 . In addition, the rate of walled-off necrosis in the DRPM group tended to be lower than in the non-DRPM group 37.5 vs 64.7 , respectively, P 0.069 . The results of the present study suggest that CRAI with DRPM and NM for SAP could have equivalent therapeutic effects to CRAI with other carbapenem antibiotics and NM.

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“…Early imipenem/cilastatin combination was associated with significant reduction in need for surgery, overall number of major organ complications and, a trend towards reduction of mortality [22].…”

Section: Role Of Intravenous Antibioticsmentioning

confidence: 96%