Early thymic T cell development in young transgenic mice overexpressing human Cu/Zn superoxide dismutase, a model of Down syndrome

Laurent, Julien; Paly, Evelyne; Marche, Patrice N.; London, Jacqueline

doi:10.1016/j.freeradbiomed.2006.01.029

Cited by 8 publications

(6 citation statements)

References 54 publications

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“…thymocyte differentiation via their effects on NF-jB [35] which plays a crucial role in lymphocyte maturation [36]. Similarly, transgenic mice over-expressing Cu/Zn superoxide dismutase exhibit various immunological abnormalities, including an early thymic involution [37,38].…”

Section: Introductionmentioning

confidence: 99%

Enhanced susceptibility of T lymphocytes to oxidative stress in the absence of the cellular prion protein

Aude-Garcia

Villiers

Candéias

et al. 2010

Cell. Mol. Life Sci.

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The cellular prion glycoprotein (PrP(C)) is ubiquitously expressed but its physiologic functions remain enigmatic, particularly in the immune system. Here, we demonstrate in vitro and in vivo that PrP(C) is involved in T lymphocytes response to oxidative stress. By monitoring the intracellular level of reduced glutathione, we show that PrP(-/-) thymocytes display a higher susceptibility to H(2)O(2) exposure than PrP(+/+) cells. Furthermore, we find that in mice fed with a restricted diet, a regimen known to increase the intracellular level of ROS, PrP(-/-) thymocytes are more sensitive to oxidative stress. PrP(C) function appears to be specific for oxidative stress, since no significant differences are observed between PrP(-/-) and PrP(+/+) mice exposed to other kinds of stress. We also show a marked evolution of the redox status of T cells throughout differentiation in the thymus. Taken together, our results clearly ascribe to PrP(C) a protective function in thymocytes against oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Enhanced susceptibility of T lymphocytes to oxidative stress in the absence of the cellular prion protein

Aude-Garcia

Villiers

Candéias

et al. 2010

Cell. Mol. Life Sci.

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“…The Cu(II) is further coordinated to three histidine residues and a water molecule to form a distorted square pyramidal geometry, while the Zn(II) coordination is further completed by a two histidine and one aspartate residues in a distorted tetrahedral geometry [1,2]. However, the overproduction of Cu 2 Zn 2 SOD (including its mutants) does not result in increased protection but rather creates a variety of unfavorable effects, and has been found to be a primary cause of many symptoms of certain diseases, suggesting that too much Cu 2 Zn 2 SOD may be injurious to the cells [3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

DNA cleavage mediated by copper superoxide dismutase via two pathways

Han¹,

Shen²,

Jian³

et al. 2007

Journal of Inorganic Biochemistry

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“…3). The importance of Sod1 and IMPD2 has been shown in T cells [50], [51], but not previously in B cells. The protein abundance pattern of HspΒ1 (cluster 18 Figure 3) was in accordance with the maturation stage of normal B-lineage cells [52].…”

Section: Discussionmentioning

confidence: 83%

Proteomic Changes during B Cell Maturation: 2D-DIGE Approach

et al. 2013

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B cells play a pivotal role in adaptive immune system, since they maintain a delicate balance between recognition and clearance of foreign pathogens and tolerance to self. During maturation, B cells progress through a series of developmental stages defined by specific phenotypic surface markers and the rearrangement and expression of immunoglobulin (Ig) genes. To get insight into B cell proteome during the maturation pathway, we studied differential protein expression in eight human cell lines, which cover four distinctive developmental stages; early pre-B, pre-B, plasma cell and immature B cell upon anti-IgM stimulation. Our two-dimensional differential gel electrophoresis (2D-DIGE) and mass spectrometry based proteomic study indicates the involvement of large number of proteins with various functions. Notably, proteins related to cytoskeleton were relatively highly expressed in early pre-B and pre-B cells, whereas plasma cell proteome contained endoplasmic reticulum and Golgi system proteins. Our long time series analysis in anti-IgM stimulated Ramos B cells revealed the dynamic regulation of cytoskeleton organization, gene expression and metabolic pathways, among others. The findings are related to cellular processes in B cells and are discussed in relation to experimental information for the proteins and pathways they are involved in. Representative 2D-DIGE maps of different B cell maturation stages are available online at http://structure.bmc.lu.se/BcellProteome/.

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Early thymic T cell development in young transgenic mice overexpressing human Cu/Zn superoxide dismutase, a model of Down syndrome

Cited by 8 publications

References 54 publications

Enhanced susceptibility of T lymphocytes to oxidative stress in the absence of the cellular prion protein

Enhanced susceptibility of T lymphocytes to oxidative stress in the absence of the cellular prion protein

DNA cleavage mediated by copper superoxide dismutase via two pathways

Proteomic Changes during B Cell Maturation: 2D-DIGE Approach

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