Early Splenectomy in Lymphoproliferative Disorders

Hypersplenism in Hodgkin’ Disease: A report of three cases presenting with cytopenias

“…All showed improvement of their cytopenic cell lines following splenectomy. The five patients reported by Yam and Crosby [1] with Hodgkin's disease and pancytopenia who underwent splenec tomy with good hematologic response did not appear to demonstrate hypersplenism upon presentation. Some had had prior therapy.…”

“…It generally appears as a late manifestation of the disease process and is variably improved by splenectomy [1,2], Hypersplenism is reported more frequently in lymphoproliferative disorders other than Hodgkin's disease; of fifty such cases splenectomised in the series of Yam and C ro sby [1] only seven had Hodgkin's disease. M h t e l m a n et al [3] emphasises that hypersplenism, when seen in Hodgkin's disease, is usually a late and secondary manifestation of the disease.…”

Hypersplenism in Hodgkin's Disease: A Report of Three Cases and Review of the Literature

“…L. T. Yam and W. H. Crosby reported good hemotologic response in all five patients who underwent splenectomy for pancytopenia and Hodgkin's disease. 9 They advocated splenectomy at the earliest sign of hypersplenism. Nine of ten patients reported by S. Lowenbraun, et al benefited from splenectomy.…”

The Complete Spleen

“…(1992) in 34 patients with MLPDs following therapeutic splenectomy. Yam and Crosby (1974) showed that early splenectomy for hypersplenism was well-tolerated in patients with CLL, well-differentiated lymphomas, and HCL, in contrast to the poor results observed in large cell lymphomas. In a series reported by Christensen et aI.…”