Hypersplenism in Hodgkin’ Disease: A report of three cases presenting with cytopenias

Fischetti, M; Carey, William B.; Baher, C.C.

doi:10.1159/000225239

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…3 In a few reported cases hypersplenism was present at the time of original diagnosis. 4 Three cases of hypersplenism and Hodgkin's disease, two children and one young adult, were seen at the King Faisal Specialist Hospital and Research Centre during the past few years. One patient's hypersplenism was discovered at the time of diagnosis and in the other two it occurred while the patients were undergoing treatment for Hodgkin's disease.…”

Section: Introductionmentioning

confidence: 99%

Hypersplenism in Hodgkin's Disease: A Report of Three Cases and Review of the Literature

1981

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Hypersplenism may occur as a late manifestation of Hodgkin's disease or, much less commonly, as a presenting feature at the time of diagnosis. In either case, it reduces the patient's tolerance to chemotherapy and compromises his chances of survival. Splenectomy is recommended by some to correct the cytopenia and improve the patient's tolerance of cytotoxic agents. During the past few years, three patients with Hodgkin's disease and hypersplenism were seen at the King Faisal Specialist Hospital and Research Centre. In this report we describe these patients, discuss the therapeutic implications of this uncommon but serious complication, and give a brief review of the literature. RS

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Section: Introductionmentioning

confidence: 99%

Hypersplenism in Hodgkin's Disease: A Report of Three Cases and Review of the Literature

1981

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Surgical Indications in Idiopathic Splenomegaly

Carr

Shurafa²,

Velanovich³

2002

Arch Surg

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Autoimmune hemolytic anemia and autoimmune thrombocytopenia at diagnosis and during follow-up of Hodgkin lymphoma

Dimou¹,

Angelopoulou²,

Pangalis

et al. 2012

Leukemia & Lymphoma

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Autoimmune hemolytic anemia and thrombocytopenia (AIHA/AITP) frequently complicate the course of non-Hodgkin lymphomas, especially low-grade, but they are very rarely observed in Hodgkin lymphoma (HL). Consequently the frequency and the profile of patients with HL-associated AIHA/AITP have not been well defined. Among 1029 patients with HL diagnosed between 1990 and 2010, two cases of AIHA (0.19%) and three of AITP (0.29%) were identified at the presentation of disease. These patients were significantly older, and more frequently had features of advanced disease and non-nodular sclerosing histology, compared to the majority of patients, who did not have autoimmune cytopenias at diagnosis. ABVD combination chemotherapy (doxorubicin, bleomycin, vinblastine, dacarbazine) provided effective control of HL and the autoimmune condition as well. During approximately 6600 person-years of follow-up for the remaining 1024 patients, seven (0.7%) patients developed autoimmune cytopenias (three AITP, three AIHA, one autoimmune pancytopenia) for a 10- and 15-year actuarial incidence of 0.95% and 1.40%, respectively. Their features did not differ compared to the general population of adult HL. In this large series of consecutive, unselected patients, those who presented with autoimmune cytopenias had a particular demographic and disease-related profile. In contrast, patients developing autoimmune cytopenias during follow-up did not appear to differ significantly from those who did not.

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Hypersplenism in Hodgkin’ Disease: A report of three cases presenting with cytopenias

Cited by 3 publications

References 8 publications

Hypersplenism in Hodgkin's Disease: A Report of Three Cases and Review of the Literature

Hypersplenism in Hodgkin's Disease: A Report of Three Cases and Review of the Literature

Surgical Indications in Idiopathic Splenomegaly

Autoimmune hemolytic anemia and autoimmune thrombocytopenia at diagnosis and during follow-up of Hodgkin lymphoma

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