Early risk factors for cow's milk allergy in children in the first year of life

Sardecka, Izabela; Łoś-Rycharska, Ewa; Ludwig, Hanna; Gawryjołek, Julia; Krogulska, Aneta

doi:10.2500/aap.2018.39.4159

Cited by 20 publications

(25 citation statements)

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“…A positive family history, including history of allergic disorders in parents and/or siblings, is considered to be a strong determinant of allergy risk in an infant. The risk is shown to be even higher in the case of a history of atopic eczema or asthma in the family [4]. In addition, environmental factors in the pre-, peri-, and postnatal periods also seem to influence the risk of allergies in early life (Table 1) [4].…”

Section: Allergy Risk In Early Lifementioning

confidence: 99%

“…The risk is shown to be even higher in the case of a history of atopic eczema or asthma in the family [4]. In addition, environmental factors in the pre-, peri-, and postnatal periods also seem to influence the risk of allergies in early life (Table 1) [4]. However, a negative family history at birth does not rule out the future risk of allergy; the child is demonstrated to have similar levels of allergy risk if an immediate family member becomes allergic after the birth of the child [5].…”

Section: Allergy Risk In Early Lifementioning

confidence: 99%

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Prevention of Allergic Sensitization and Treatment of Cow’s Milk Protein Allergy in Early Life: The Middle-East Step-Down Consensus

Vandenplas¹,

Alhussaini

Al-Mannaei³

et al. 2019

Nutrients

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Allergy risk has become a significant public health issue with increasing prevalence. Exclusive breastfeeding is recommended for the first six months of life, but this recommendation is poorly adhered to in many parts of the world, including the Middle-East region, putting infants at risk of developing allergic sensitization and disorders. When breastfeeding is not possible or not adequate, a partially hydrolyzed whey formula (pHF-W) has shown proven benefits of preventing allergy, mainly atopic eczema, in children with a genetic risk. Therefore, besides stimulating breastfeeding, early identification of infants at risk for developing atopic disease and replacing commonly used formula based on intact cow milk protein (CMP) with a clinically proven pHF-W formula is of paramount importance for allergy prevention. If the child is affected by cow’s milk protein allergy (CMPA), expert guidelines recommend extensively hydrolyzed formula (eHF), or an amino acid formula (AAF) in case of severe symptoms. The Middle-East region has a unique practice of utilizing pHF-W as a step-down between eHF or AAF and intact CMP, which could be of benefit. The region is very heterogeneous with different levels of clinical practice, and as allergic disorders may be seen by healthcare professionals of different specialties with different levels of expertise, there is a great variability in preventive and treatment approaches within the region itself. During a consensus meeting, a new approach was discussed and unanimously approved by all participants, introducing the use of pHF-W in the therapeutic management of CMPA. This novel approach could be of worldwide benefit.

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Section: Allergy Risk In Early Lifementioning

confidence: 99%

Section: Allergy Risk In Early Lifementioning

confidence: 99%

Prevention of Allergic Sensitization and Treatment of Cow’s Milk Protein Allergy in Early Life: The Middle-East Step-Down Consensus

Vandenplas¹,

Alhussaini

Al-Mannaei³

et al. 2019

Nutrients

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show abstract

“…On the contrary, in a recent paper by Sardecka et al [ 52 ] on 138 infants with CMA and 101 healthy infants without allergy (with CMA confirmed by an elimination test and OFC), it was reported that the incidence of CMA was three times higher in infants with a positive family history for allergy. In this study it was also found that mothers of children with CMA were four times more likely to have a university-level education as compared to mothers of children without allergy [ 52 ].…”

Section: Risk Factors For Cmamentioning

confidence: 92%

“…The incidence of CMA may be higher in infants born by cesarean section because of the influence on the microbiota and, consequentially, on the immune system. Actually, no relationship between CMA and the type of delivery has ever been observed in studies [ 52 , 62 ].…”

Section: Risk Factors For Cmamentioning

confidence: 99%

Cow’s Milk Protein Allergy as a Model of Food Allergies

et al. 2021

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Cow’s milk allergy (CMA) is one of the most common food allergies in infants, and its prevalence has increased over recent years. In the present paper, we focus on CMA as a model of food allergies in children. Understanding the diagnostic features of CMA is essential in order to manage patients with this disorder, guide the use of an elimination diet, and find the best moment to start an oral food challenge (OFC) and liberalize the diet. To date, no shared tolerance markers for the diagnosis of food allergy have been identified, and OFC remains the gold standard. Recently, oral immunotherapy (OIT) has emerged as a new therapeutic strategy and has changed the natural history of CMA. Before this, patients had to strictly avoid the food allergen, resulting in a decline in quality of life and subsequent nutritional, social, and psychological impairments. Thanks to the introduction of OIT, the passive approach involving rigid exclusion has changed to a proactive one. Both the heterogeneity in the diagnostic process among the studies and the variability of OIT data limit the comprehension of the real epidemiology of CMA, and, consequentially, its natural history. Therefore, well-planned randomized controlled trials are needed to standardize CMA diagnosis, prevention, and treatment strategies.

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“…The authors report that the majority of patients with peanut allergy will have negative skin test results and food challenges to certain tree nuts, especially macadamia, pine nut, and coconut. In a second food allergy article, Sardecka et al 16 report on early risk factors for cow's milk allergy in children in their first year of life. They conclude that a positive family history of allergy and a higher degree of maternal education increased the risk of cow's milk allergy in children in the first year of life, while having pets at home and longer periods of breast-feeding decreased the risk.…”

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confidence: 99%