Early response evaluation using CT-perfusion one day after transarterial chemoembolization for HCC predicts treatment response and long-term disease control

Tamandl, Dietmar; Waneck, Fredrik; Unterhumer, Sylvia; Kölblinger, Claus; Baltzer, Pascal; Ba‐Ssalamah, Ahmed; Loewe, Christian

doi:10.1016/j.ejrad.2017.02.032

Cited by 22 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Four studies found that CTp parameters were able to assess response to TACE treatment in HCC patients. 55 , 57 , 69 , 72 Results from 3 studies 68 , 76 , 80 revealed that CTp could help to evaluate the therapeutic response in HCC patients treated with sorafenib. D’Onofrio et al 67 and Ng et al 79 evaluated the role of CTp in patients with liver metastases arising from pancreatic neuroendocrine tumors and found that CTp was able to predict response to everolimus and bevacizumab therapy.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review on the Role of the Perfusion Computed Tomography in Abdominal Cancer

et al. 2021

View full text Add to dashboard Cite

Background and purpose Perfusion Computed Tomography (CTp) is an imaging technique which allows quantitative and qualitative evaluation of tissue perfusion through dynamic CT acquisitions. Since CTp is still considered a research tool in the field of abdominal imaging, the aim of this work is to provide a systematic summary of the current literature on CTp in the abdominal region to clarify the role of this technique for abdominal cancer applications. Materials and Methods A systematic literature search of PubMed, Web of Science, and Scopus was performed to identify original articles involving the use of CTp for clinical applications in abdominal cancer since 2011. Studies were included if they reported original data on CTp and investigated the clinical applications of CTp in abdominal cancer. Results Fifty-seven studies were finally included in the study. Most of the included articles (33/57) dealt with CTp at the level of the liver, while a low number of studies investigated CTp for oncologic diseases involving UGI tract (8/57), pancreas (8/57), kidneys (3/57), and colon–rectum (5/57). Conclusions Our study revealed that CTp could be a valuable functional imaging tool in the field of abdominal oncology, particularly as a biomarker for monitoring the response to anti-tumoral treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

A Systematic Review on the Role of the Perfusion Computed Tomography in Abdominal Cancer

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Studies have shown a significant reduction in hepatic arterial perfusion (AP) and total hepatic BV predictive of favorable treatment response. [43][44][45] In the study by Chen et al, AP, hepatic arterial fraction, and BV reduced significantly on perfusion CT following TACE when compared with the pre-TACE values in patients with partial response (PR). 44 On the other hand, these values showed a significant increase in the patients with PD.…”

Section: Perfusion Imagingmentioning

confidence: 99%

Response Assessment Following Image-Guided Therapy of Hepatocellular Carcinoma

Gupta

Kalra

Gulati

et al. 2020

Journal of Clinical Interventional Radiology ISVIR

View full text Add to dashboard Cite

AbstractImage-guided locoregional therapies have an important role in the management of patients with hepatocellular carcinoma (HCC). Recent advances in the ablative as well as endovascular therapies have expanded the role of interventional radiologists in the treatment of HCC. Following image-guided therapy, an accurate response assessment is vital. Knowledge regarding normal postprocedure changes and subtle signs of residual or recurrent disease is important. In this review, we discuss various response evaluation criteria currently employed for HCC. We also discuss the postprocedure imaging features suggestive of residual disease or recurrence and imaging biomarkers for response assessment.

show abstract

“…In the assessment of tumor biology and angiogenesis, compartmental analysis of CT perfusion imaging provides a noninvasive volumetric assessment of tumor vasculature [11,[43][44][45][46]. Correlation between parametric maps obtained from compartmental analysis and microvessel structure has been used as a predictor of disease severity and treatment outcomes [47][48][49][50].…”

Section: Compartmental Modelmentioning

confidence: 99%

Imaging-based characterization of convective tissue properties

Fuentes

Thompson

Jacobsen

et al. 2020

International Journal of Hyperthermia

View full text Add to dashboard Cite

Convective transport is an important phenomenon for nanomedicine delivery. We present an imaging-based approach to recover tissue properties that are significant in the accumulation of nanoparticles delivered via systemic methods. The classical pharmacokinetic analysis develops governing equations for the particle transport from a first principle mass balance. Fundamentally, the governing equations for compartmental mass balance represent a spatially invariant mass transport between compartments and do not capture spatially variant convection phenomena. Further, the parameters recovered from this approach do not necessarily have direct meaning with respect to the governing equations for convective transport. In our approach, a framework is presented for directly measuring permeability in the sense of Darcy flow through porous tissue. Measurements from our approach are compared to an extended Tofts model as a control. We demonstrate that a pixel-wise iterative clustering algorithm may be applied to reduce the parameter space of the measurements. We show that measurements obtained from our approach are correlated with measurements obtained from the extended Tofts model control. These correlations demonstrate that the proposed approach contains similar information to an established compartmental model and may be useful in providing an alternative theoretical framework for parameterizing mathematical models for treatment planning and diagnostic studies involving nanomedicine where convection dominated effects are important.

show abstract

Early response evaluation using CT-perfusion one day after transarterial chemoembolization for HCC predicts treatment response and long-term disease control

Cited by 22 publications

References 25 publications

A Systematic Review on the Role of the Perfusion Computed Tomography in Abdominal Cancer

A Systematic Review on the Role of the Perfusion Computed Tomography in Abdominal Cancer

Response Assessment Following Image-Guided Therapy of Hepatocellular Carcinoma

Imaging-based characterization of convective tissue properties

Contact Info

Product

Resources

About