A Systematic Review on the Role of the Perfusion Computed Tomography in Abdominal Cancer

Abstract

Background and purpose Perfusion Computed Tomography (CTp) is an imaging technique which allows quantitative and qualitative evaluation of tissue perfusion through dynamic CT acquisitions. Since CTp is still considered a research tool in the field of abdominal imaging, the aim of this work is to provide a systematic summary of the current literature on CTp in the abdominal region to clarify the role of this technique for abdominal cancer applications. Materials and Methods A systematic literature search of PubMed, Web of Science, and Scopus was performed to identify original articles involving the use of CTp for clinical applications in abdominal cancer since 2011. Studies were included if they reported original data on CTp and investigated the clinical applications of CTp in abdominal cancer. Results Fifty-seven studies were finally included in the study. Most of the included articles (33/57) dealt with CTp at the level of the liver, while a low number of studies investigated CTp for oncologic diseases involving UGI tract (8/57), pancreas (8/57), kidneys (3/57), and colon–rectum (5/57). Conclusions Our study revealed that CTp could be a valuable functional imaging tool in the field of abdominal oncology, particularly as a biomarker for monitoring the response to anti-tumoral treatment.

A Comprehensive Study on the Diagnostic Value of Multi-Slice Computed Tomography for Peripancreatic Infection in Elderly With Severe Acute Pancreatitis

“…This principle can be utilized to measure perfusion parameters of tissues, effectively and quantitatively reflecting changes in local tissue blood perfusion, particularly in pancreatic and liver tissues. Consequently, it can be employed to evaluate tissue pathological changes and inflammatory infiltration [ 25 ]. Prior studies have indicated significant inflammatory exudate presence in patients with SAP-related pancreatic infection, affecting tissue perfusion, blood supply, and increasing the risk of pancreatic necrosis [ 26 ].…”