Early Regression of Carotid Intima-Media Thickness after Bariatric Surgery and Its Relation to Serum Leptin Reduction

Lambert, Grégory; Lima, Marcelo Miranda de Oliveira; Felici, Ana Claudia; Pareja, José Carlos; Vasques, Ana Carolina Junqueira; Novaes, Fernanda Satake; Rodovalho, S.; Hirsch, Fernanda Filgueira; Matos‐Souza, José R.; Chaim, Élinton Adami; Geloneze, Bruno

doi:10.1007/s11695-017-2839-7

Cited by 18 publications

(16 citation statements)

References 37 publications

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“…We found that the reductions in LAR were driven primarily by an increase in adiponectin rather than a reduction in leptin, and these changes were proportional to the reduction in weight after surgery, consistent with the Unamuno study. The changes we observed in leptin and adiponectin concentrations were less than those described after bypass bariatric surgery 3,6,7 and are more consistent with those previously described after banding 8 .…”

Section: Discussionsupporting

confidence: 91%

“…We have shown that in a predominantly white cohort of adults with severe obesity who underwent laparoscopic sleeve gastrectomy, there was a substantial reduction in the LAR after 12 months, which may indicate an increase in insulin sensitivity. While several studies have measured leptin or adiponectin separately in patients after bariatric surgery 3,[6][7][8]15 , we are aware of only one other study by Unamuno et al that has considered them together as a ratio and as an indicator of adipocyte dysfunction 16 . Ours is the first study to consider these adipokines as a ratio in patients undergoing laparoscopic sleeve gastrectomy.…”

Section: Discussionmentioning

confidence: 99%

“…Obesity is a major determinant of type 2 diabetes risk, primarily through its adverse effects on insulin sensitivity 1 . Bariatric surgery to treat severe obesity leads to significant improvements in diabetes control 2 , cardiovascular risk 3,4 , microalbuminuria 5 and systemic inflammation 6 . However, the influence of bariatric surgery on insulin sensitivity is not well defined 7,8 , partly because quantifying insulin sensitivity can be challenging.…”

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confidence: 99%

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The leptin to adiponectin ratio (LAR) is reduced by sleeve gastrectomy in adults with severe obesity: a prospective cohort study

Rafey

Fang

Ioana

et al. 2020

Sci Rep

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Bariatric surgery is known to reduce leptin and increase adiponectin levels, but the influence of sleeve gastrectomy on the leptin: adiponectin ratio (LAR), a measure of insulin sensitivity and cardiovascular risk, has not previously been described. We sought to determine the influence of sleeve gastrectomy on LAR in adults with severe obesity.In a single centre prospective cohort study of adults undergoing laparoscopic sleeve gastrectomy over a four-month period in our unit, we measured LAR preoperatively and 12 months after surgery. Of 22 patients undergoing sleeve gastrectomy, 17 (12 females, 12 with type 2 diabetes) had follow-up LAR measured at 12.1 ± 1 months. Mean body weight decreased from 130.6 ± 30.8 kg to 97.6 ± 21.6 kg, body mass index (BMI) from 46.9 ± 7.8 to 35.3 ± 7.2 kg m−2 and excess body weight from 87.5 ± 31.3 to 41.3 ± 28.8% (all p < 0.001). The reduction in leptin from 40.7 ± 24.9 to 30.9 ± 30.5 ng/ml was not significant (p = 0.11), but adiponectin increased from 4.49 ± 1.6 to 8.93 ± 6.36 µg/ml (p = 0.005) and LAR decreased from 8.89 ± 4.8 to 5.26 ± 6.52 ng/µg (p = 0.001), equivalent to a 70.9% increase in insulin sensitivity. The correlation with the amount of weight lost was stronger for LAR than it was for leptin or adiponectin alone. In this single-centre, interventional prospective cohort, patients undergoing laparoscopic sleeve gastrectomy had a substantial reduction in their LAR after 12 months which was proportional to the amount of weight lost. This may indicate an improvement in insulin sensitivity and a reduction in cardiovascular risk.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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The leptin to adiponectin ratio (LAR) is reduced by sleeve gastrectomy in adults with severe obesity: a prospective cohort study

Rafey

Fang

Ioana

et al. 2020

Sci Rep

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“…The CIMT is positively correlated with serum leptin levels in patients with psoriasis (56) and premenopausal systemic lupus erythematosus patients (57). Lambert et al indicated that an obvious C-IMT regression is associated with a reduction in leptin levels, independent of the weight loss (58). However, the correlation between leptin and IMT in OSA patients is still unclear and requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Song

et al. 2020

Front. Endocrinol.

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Objective: Obstructive sleep apnea (OSA) results in increased carotid intima-media thickness (IMT) and arterial stiffness; however, the association between adipocytokines and IMT/arterial stiffness in OSA patients is unclear. Methods:We enrolled 95 normal weight and overweight, not obese, participants from May 2018 to December 2018 in this study. All subjects underwent a carotid artery ultrasound examination and polysomnography. Blood samples were used to determine serum chemerin, adiponectin, SFRP5, and apelin levels. Correlations between two quantitative variables were assessed using the Pearson or Spearman coefficient.Stepwise models of multiple linear regression analysis were performed to assess the independent relationships.Result: IMT in OSA patients was significantly higher than in the non-snorers. There were significant differences in the arterial stiffness parameters such as distensibility coefficient (DC), compliance coefficient (CC), and pulse wave velocity (PWV). SFRP5 level was lower in OSA patients than in non-snorers. Adiponectin correlated with CC, DC, and PWV among OSA patients; however, the relationship disappeared after a multivariable adjustment. Age was independently associated with all quantitative IMT and stiffness indices. AHI and minimum oxygen saturation (Mini SaO 2 ) were independently related to arterial stiffness. Conclusion:The quantitative IMT and carotid arterial elasticity were significantly worse among OSA patients. Age was the main independent factor correlated with quantitative IMT and arterial stiffness, and AHI and mini SaO 2 were associated factors. There were no relationships between aforementioned adipocytokines and quantitative IMT/carotid arterial stiffness.

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“…In addition, studies were performed in subjects with different baseline BMIs, 7 were in subjects between 30-39.9 kg/m 2 [29,40,72,75,94,99,111]…”

Section: Study Selectionmentioning

confidence: 99%

Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis

et al. 2020

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Different adipokines secreted from adipose tissue, exert a range of physiological effects. The aim of present systematic review and meta-analysis was to critically investigate the consequence of bariatric surgery on circulating adipokines, that is, adiponectin, leptin, visfatin, resistin, plasminogen activator inhibitor, and chemerin. After systematically checking the following electronic databases: ISI web of Science, Scopus and PubMed without limitation in time and language up to February 2019, a pool based on a random effect model was established. Eighty-five eligible studies were entered for quantitative analysis. Our meta-analysis revealed that circulating adiponectin increased significantly after bariatric surgery [Standardized mean difference (SMD)=1.401, 95% CI: 1.101, 1.701, p<0.001]; whilst leptin (SMD=–2.178, 95% CI: –2.433, –1.923, p<0.001), PAI-1 (–14.928 ng/ml 95% CI: –21.794, –8.063, p<0.001), and chemerin (–50.238 ng/ml 95% CI: –85.708, –14.768, p<0.001) decreased. However, serum visfatin (2.05 ng/ml, 95% CI: –5.07, 9.17, p=0.573) and resistin (–2.080 ng/ml, 95% CI: –5.352, 1.192, p=0.21) were unchanged. In conclusion, bariatric surgery is associated with a reduction in specific adipokines including leptin, chemerin, and PAI-1, whereas adiponectin is raised, adaptations that could be indicative of improved fat mass and function.

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Early Regression of Carotid Intima-Media Thickness after Bariatric Surgery and Its Relation to Serum Leptin Reduction

Cited by 18 publications

References 37 publications

The leptin to adiponectin ratio (LAR) is reduced by sleeve gastrectomy in adults with severe obesity: a prospective cohort study

The leptin to adiponectin ratio (LAR) is reduced by sleeve gastrectomy in adults with severe obesity: a prospective cohort study

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis

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