Early Recurrence of Nephrotic Syndrome (Immunoglobulin M Nephropathy) After Renal Transplantation Successfully Treated With Combinations of Plasma Exchanges, Immunoglobulin, and Rituximab

Westphal, Susanne; Hansson, Sverker; Mjörnstedt, L.; Mölne, Johan; Swerkersson, Svante; Friman, Styrbjörn

doi:10.1016/j.transproceed.2006.07.034

Cited by 24 publications

(20 citation statements)

References 6 publications

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“…Another report describes the resolution of proteinuria in a boy with recurrence of his nephrotic syndrome on day 1 post-transplantation, the diagnosis in his native kidneys being IgM nephropathy [19]. A single dose of rituximab was given, alongside plasma exchange, immunoglobulin and anti-thymocyte globulin, and, therefore, the precise role of the rituximab is difficult to ascertain.…”

Section: Discussionmentioning

confidence: 99%

“…In one patient six doses were given [17], and in the remaining case [19], only one dose of rituximab was administered. However, this was the patient for whom multiple therapies were used concurrently.…”

Section: Discussionmentioning

confidence: 99%

“…The importance of B-cells is further supported by recent case studies describing the successful use of the anti-CD20 monoclonal antibody rituximab in the management of difficult cases of nephrotic syndrome [15][16][17][18][19][20][21], and I would like to add to this evidence base.…”

Section: Introductionmentioning

confidence: 97%

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Is there a role for rituximab in the treatment of idiopathic childhood nephrotic syndrome?

Smith

2007

Pediatr Nephrol

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We each have nephrotic patients who become steroid dependent and in whom multiple immunosuppressive agents are employed. There is a need to balance possible therapeutic benefits with drug toxicity. This case report describes such a patient, who has suffered from nephrotic syndrome for over 11 years and had become resistant to the usual therapies. He was therefore given a single dose of the anti-CD20 drug rituximab, to which he showed a prompt response, leaving him free of proteinuria for the past 10 months.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Is there a role for rituximab in the treatment of idiopathic childhood nephrotic syndrome?

Smith

2007

Pediatr Nephrol

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“…In this case, we believe that management was started sufficiently early and aggressively in order to prevent any negative outcome for her new transplanted kidney. The benefit of Rituximab has been suggested in multiple case series and case reports [10][11][12][13][14][15][16][17][18][19]. The number of doses given varies in different studies between 1-6 doses, with an overall success rate of up to 64%.…”

Section: Discussionmentioning

confidence: 99%

Ablative Therapy in 2016 for Small Renal Masses

Sriprasad¹

2017

UNOAJ

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“…IgMN often presents with refractory nephrotic syndrome which may respond to steroid treatment [2,3] . Two articles published in 1978 by independent groups [4,5] are considered by many authors to be the first descriptions of a glomerulopathy characterised by diffuse mesangial deposits of immunoglobulin M (IgM) in patients with relatively normal light microscopy.…”

Section: Introductionmentioning

confidence: 99%