Early Recurrence and Death After Esophagectomy in Patients With Esophageal Squamous Cell Carcinoma

Zhu, Zi-Jiang; Hu, Yang; Zhao, Yaopeng; Chen, Xuezhong; Chen, Long-Qi; Chen, Yingtai

doi:10.1016/j.athoracsur.2011.01.007

Cited by 49 publications

(47 citation statements)

References 28 publications

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“…The liver was the most common organ for metastasis. This finding is similar to those in patients with squamous cell carcinoma . In this study, only one patient was confirmed to have brain metastases, and none of the patients had confirmed bone metastases.…”

Section: Discussionsupporting

confidence: 89%

“…This finding is similar to those in patients with squamous cell carcinoma. 32 In this study, only one patient was confirmed to have brain metastases, and none of the patients had confirmed bone metastases. These results are similar to those obtained in a previous study of patients with SCCE but different from the metastases findings in patients with SCLC.…”

Section: Figmentioning

confidence: 61%

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Role of surgery in the management and prognosis of limited-stage small cell carcinoma of the esophagus

Xie

Sun

et al. 2014

Dis Esophagus

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Small cell carcinoma of the esophagus (SCCE) is a rare, highly aggressive tumor characterized by early dissemination and a poor prognosis. Surgery, chemotherapy, and radiotherapy have been used alone or in combination for the treatment of this rare disease. The aim of this retrospective study was to analyze the role of surgery in the management of limited-stage SCCE at a high-volume center. We retrospectively evaluated 73 patients with limited-stage SCCE who received an esophagectomy at our center from January 1994 to December 2011. The clinical characteristics, median survival times (MSTs), overall survival (OS), and relevant prognostic factors were analyzed. The overall MST was 23.0 months, and the 1-, 2-, 3-, and 5-year OS rates were 61.6%, 47.9%, 22.7%, and 10.6%, respectively. The MST for patients without lymph node involvement (33.0 months) was greater than the MST for patients with lymph node involvement (17.0 months) (P = 0.014). Similarly, patients who underwent radical resection had a greater MST (25.0 months) than patients who underwent palliative resection (7.0 months) (P = 0.004). Patients who received chemotherapy had a greater MST (27.0 months) than patients who did not receive chemotherapy (13.0 months) (P = 0.021). Survival analysis confirmed that a radical operation, chemotherapy, and lymph node involvement were independent prognostic factors. This study suggests that radical resection combined with chemotherapy should be recommended for patients with limited-stage SCCE, especially patients with negative regional lymph nodes. A lack of lymph node metastasis was a good prognostic factor because patients without lymph node involvement had greater OS.

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Section: Discussionsupporting

confidence: 89%

Section: Figmentioning

confidence: 61%

Role of surgery in the management and prognosis of limited-stage small cell carcinoma of the esophagus

Xie

Sun

et al. 2014

Dis Esophagus

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“…A large study from China assessed early recurrence after resection for squamous cell carcinomas of the esophagus, concluding similar markers of adverse prognosis to those found in our study [1]. Approximately 52% of the recurrences in their series were metastatic disease with the remainder being local or regional.…”

Section: Discussionsupporting

confidence: 81%

Factors associated with early recurrence and death after esophagectomy for cancer

Davies

Pillai

Sinha

et al. 2013

Journal of Surgical Oncology

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“…Little is known about the risk factors for early recurrence in patients with esophageal cancer after curative resection [15]. The present study revealed that the presence of three or more lymph node metastases was an independent risk factor for early (within 180 days) recurrence.…”

Section: Discussionmentioning

confidence: 70%

“…There are many reports regarding the factors that affect survival and recurrence in patients with esophageal cancer [10][11][12][13][14]. Little, however, is known about the predictors for early recurrence in esophageal cancer after curative resection [15]. Regarding a disadvantage of invasive surgery for esophageal cancer, a disease-free survival (DFS) time within 180 days of operation is hard to accept.…”

Section: Introductionmentioning

confidence: 99%

Predictive factors for early recurrence in patients with esophageal squamous cell carcinoma after curative esophagectomy

et al. 2012

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Background Even after curative resection with combined modality treatment by chemotherapy and radiation, esophageal cancer has remained a disease with poor prognosis upon early recurrence. In this study, the clinicopathological predictive factors for early recurrence in patients with curative resected esophageal cancer were retrospectively evaluated. Methods Eighty-one consecutive patients who had recurrence of primary esophageal squamous cell carcinoma after curative resection were analyzed. The patients were classified into two subgroups by time of recurrence (within 180 days of surgery or later): an early group and a late group. Results Twenty-seven (33.3%) and 54 (66.7%) patients were classified into the early and late groups, respectively. Patients in the early group had significantly deeper tumors than those in the late group. The initial recurrence patterns were not significantly different between the two groups, and distant recurrences were found in two-thirds of patients in both groups. The 1-year survival rates of patients in the early and late groups were 11 and 62%, respectively. The survival rate after recurrence of patients in the early group was significantly poorer than that of patients in the late group (p \ 0.0001). Multivariate logistic regression analysis revealed that the presence of three or more pathological lymph node metastases was an independent risk factor associated with early recurrence.Conclusions Early distant recurrences of esophageal cancer frequently occurred even after curative surgery. The number of pathological lymph node metastases (three or more) was the independent risk factor for early recurrence in patients with esophageal cancer after curative resection.

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Early Recurrence and Death After Esophagectomy in Patients With Esophageal Squamous Cell Carcinoma

Cited by 49 publications

References 28 publications

Role of surgery in the management and prognosis of limited-stage small cell carcinoma of the esophagus

Role of surgery in the management and prognosis of limited-stage small cell carcinoma of the esophagus

Factors associated with early recurrence and death after esophagectomy for cancer

Predictive factors for early recurrence in patients with esophageal squamous cell carcinoma after curative esophagectomy

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