Early rapid weight gain and current overweight in relation to asthma in adolescents born with very low birth weight

Mai, Xiao-Mei; Gäddlin, Per-Olof; Nilsson, Lennart; Leijon, Ingemar

doi:10.1111/j.1399-3038.2005.00290.x

Cited by 36 publications

(52 citation statements)

References 29 publications

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“…Eighteen studies were identified for full text review. Of those, twelve studies, listed in Table 1 by year, were excluded: six did not report physician-diagnosed asthma [33-38], two did not categorize overweight/obesity by BMI [39,40], one did not report incident asthma as the primary outcome [41], two reported only adult populations [42,43], and one used a cross-sectional analysis [44]. …”

Section: Resultsmentioning

confidence: 99%

Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies

2013

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BackgroundChildhood asthma and obesity prevalence have increased in recent years suggesting a potential association. However, the direction of any association is poorly understood and the potential causal-relationship is unknown.MethodsWe examined the association between overweight/obesity, defined by body mass index (BMI) <18 years of age, and subsequent physician-diagnosed incident asthma at least one year after BMI assessment. We sought to explore potential effect modification by sex. PubMed and Embase were searched using keywords and restricted to subjects aged 0–18 years. There were no date or language restrictions. From each study we extracted: authors, publication date, location, overweight/obesity definitions, asthma definitions, number of participants, recruitment duration, description of cohort, follow-up time, adjusted effect estimates (with 95% CI) and estimates of subgroup analysis.ResultsSix prospective cohort studies which focused on children <18 years of age met criteria for inclusion. The combined risk ratio (RR) of overweight was associated with asthma (RR = 1.35; 95% CI = 1.15, 1.58). In boys, the combined RR of overweight on asthma was significant (RR = 1.41; 95% CI = 1.05, 1.88). For girls, when BMI was defined by Z-score, the combined RR of overweight on asthma was also significant (RR = 1.19; 95% CI = 1.06, 1.34). The combined risk ratio (RR) of obesity was associated with asthma in both boys and girls (RR = 1.50; 95% CI = 1.22, 1.83), in boys only (RR = 1.40; 95% CI = 1.01, 1.93) and in girls only (RR = 1.53; 95% CI = 1.09, 2.14).ConclusionsOverweight and, especially, obese children are at increased risk of subsequent physician diagnosed asthma in comparison to normal weight children. Except for sex, no studies reported any other potential effect modifiers. The observed sex effects were inconsistent.

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Section: Resultsmentioning

confidence: 99%

Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies

2013

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“…After reading the abstracts of these articles, we chose 27 for full reading. Of these, 10 were selected to be included in the present review (5,11–19).…”

Section: Resultsmentioning

confidence: 99%

Childhood body mass index and risk of asthma in adolescence: a systematic review

et al. 2011

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Asthma and obesity, both of which are considered global health issues, affect approximately 300 million individuals worldwide. The observation that asthma and obesity tend to increase in parallel may indicate a potential link between these two conditions. The aim of this systematic review of the literature was to investigate the relationship between childhood nutritional status and incidence or persistence of asthma during adolescence. The principal eligibility criteria for selection of articles were including longitudinal analysis, and which measured of exposure during childhood or adolescence and outcome during adolescence. The systematic search initially returned 1563 unique articles. After inspection of titles and reading the abstracts of these articles, we chose 27 for full reading. Of these, 10 were selected to be included in the present review. Of the 10 selected studies, eight showed positive associations between overweight/obesity and asthma. Of these, two were independent of sex, three were found only among men and another three only among women. The present study shows strong evidence that, although the role of sex is not clear, obesity precedes, and is associated with, the persistence and intensity of symptoms of asthma.

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“…It is an endogen protein whose role is related to the satiation's control, regulation of immune response, lung function, metabolism and micronutrients regulation. [23][24][25][26][27] Mai et al 28 assessed the concentration of leptin found in asthmatic and overweight children. It was observed that the low serum concentration was a protection factor to the development of asthma.…”

Section: Mechanisms Of Relation Between Obesity and Asthmamentioning

confidence: 99%

Obesidade e asma: associação ou coincidência?

Camilo¹,

Ribeiro²,

Toro³

et al. 2010

J. Pediatr. (Rio J.)

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Objective: Asthma and obesity are among the major causes of morbidity in childhood and adolescence. Early obesity increases the chances of chronic degenerative diseases in adults. Although the concomitance or both clinical situations are being demonstrated in various studies, the intrinsic mechanisms of this association are still very little known. Therefore, the objective of this article was to review the main studies on the association of obesity and asthma and check if there is a cause-effect relation between them.Sources: Systematic review based on indexed data bases MEDLINE (PubMed) and SciELO. Original articles (cross-sectional, case-control, and prospective studies) and meta-analysis published in the period that ranges from January 1998 to January 2008 were reviewed. Studies published in English, Spanish, and Portuguese were researched. Summary of the findings:Although there are various studies on growing prevalence of asthma and obesity, few of them establish cause-effect relations between them. Physiopathological mechanisms and factors involved in this process are still little known. Conclusion:Methodological rigor in future studies must seek for answers to better understand if there is association between asthma and obesity or if the relationship between both diseases is a coincidence.

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Early rapid weight gain and current overweight in relation to asthma in adolescents born with very low birth weight

Cited by 36 publications

References 29 publications

Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies

Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies

Childhood body mass index and risk of asthma in adolescence: a systematic review

Obesidade e asma: associação ou coincidência?

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