Early Puberty-Menarche After Precocious Pubarche: Relation to Prenatal Growth

Ibáñez, Lourdes; Jiménez, Rafael; Zegher, Francis de

doi:10.1542/peds.2005-0664

Cited by 164 publications

(99 citation statements)

References 32 publications

(33 reference statements)

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“…PCOS is typically associated with menstrual irregularities, obesity, hyperandrogenism, chronic an-ovulation and infertility [11,12]. Androgen overproduction is the key physio-pathologic feature of PCOS [13].…”

Section: Discussionmentioning

confidence: 99%

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Free testosterone and dehydroepiandrosterone sulfate serum levels in polycystic ovary syndrome women

Mostafa

Al-Sherbeeny²,

Abdelazim³

et al. 2017

Journal of Advanced Medical Sciences and Applied Technologies

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Objectives: This study designed to detect the prevalence of ovarian and/or adrenal hyperandrogenism in women with Polycystic Ovary Syndrome (PCOS). Materials:One hundred PCOS women included in this cross sectional study after informed consent and approval of the study by local institute ethical committee. Diagnosis of PCOS based on the Rotterdam ESHRE criteria. Studied women underwent complete physical examination with calculation of body mass index (BMI) and assessment of hirsutism by modified Ferriman Gallway score. Clotted blood sample taken from studied women for measurement of serum total testosterone, sex hormone binding globulin (SHBG) and dehydroepiandrosterone sulfate (DHEAS) to detect the prevalence of ovarian and/or adrenal hyperandrogenism in PCOS women.Results: 66% of studied PCOS women presented with hirsutism, 22% of studied PCOS women presented with menstrual irregularities (hypomenorrhea, oligomenorrhea) and dysmenorrhea was the presenting symptom in 12%. Free testosterone was elevated in 50 cases of studied women; DHEAS was elevated in 30 cases of studied women while the remaining 20 cases had elevated both free testosterone and DHEAS. Mean free testosterone was 2.6±1.8 pg/ml and mean DHEAS was 5.5±3.8 mg/l. Conclusion:The ovary is the main source of excess androgen in PCOS (50% of studied women) and excess adrenal androgen found in 30% of studied PCOS women, further large studies recommended to confirm this finding.

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Section: Discussionmentioning

confidence: 99%

“…In addition, Dumesic et al and Ibáñez et al concluded that PCOS is typically associated with menstrual irregularities, obesity, hyperandrogenism, chronic anovulation and infertility [11,12].…”

Section: Mean±sd Median Rangementioning

confidence: 99%

Free testosterone and dehydroepiandrosterone sulfate serum levels in polycystic ovary syndrome women

Mostafa

Al-Sherbeeny²,

Abdelazim³

et al. 2017

Journal of Advanced Medical Sciences and Applied Technologies

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“…For instance, prepubertal restriction or excess of food and adiposity may lead to delayed or early puberty, respectively (Biro et al, 2006;Dunger et al, 2006;Ong et al, 2004Ong et al, , 2006Cheng et al, 2012;Himes, 2006;Roa and Tena-Sempere, 2010) whereas intrauterine growth restriction is associated with early puberty (Ibanez et al, 2011(Ibanez et al, , 2006 in humans. Similarly, psychosocial stress during prepuberty or puberty may cause pubertal delay or arrest (van Noord and Kaaks, 1991;Tahirovic, 1998) whereas advancement of puberty has been described in children who had experienced such stress in early postnatal life or infancy (Moffitt et al, 1992;Wierson et al, 1993).…”

Section: Dual Critical Periods (Fetal/neonatal Life Vs Prepuberty) Fomentioning

confidence: 99%

“…A less heterogeneous condition could be the premature increase in adrenal androgens or premature adrenarche. In this condition where the exposure to unusually high levels of androgens is presumably in the prepubertal period, early menarche has been reported as a function of the severity of intrauterine growth retardation (Ibanez et al, 2006). Treatment with metformin prevents the advancement of menarche (Ibanez et al, 2011) indicating that the determinant of pubertal timing in that condition may be related to prenatal nutritional status (see Section 3.1.2.1) and postnatal insulin sensitivity with no or minor role of adrenal androgens.…”

Section: Critical Windows For the Effects Of Sex Steroids On Pubertymentioning

confidence: 99%

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Parent

Franssen

Fudvoye

et al. 2015

Frontiers in Neuroendocrinology

154

139

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Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such distortion of distribution is a recent phenomenon. This suggests changing environmental influences including the possible role of nutrition, stress and endocrine disruptors. Our ability to assess neuroendocrine effects and mechanisms is very limited in humans. Using the rodent as a model, we examine the impact of environmental factors on the individual variations in pubertal timing and the possible underlying mechanisms. The capacity of environmental factors to shape functioning of the neuroendocrine system is thought to be maximal during fetal and early postnatal life and possibly less important when approaching the time of onset of puberty.

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“…The onset of puberty is one of the key characteristics of this event (Palmert & Boepple 2001, Palmert & Hischhorn 2003, Sisk & Foster 2004, Francis 2005. The calculated heritability in previous studies suggested that up to 50 to 80% of the variance in the timing of pubertal onset may be genetically controlled (Meyer et al 1991, Loesch et al 1995, Palmert & Boepple 2001, Ibanez et al 2006. Genetic analysis indicated that familial central precocious puberty was an autosomal dominant transmission with an incomplete, sexdependent penetrance (Vries et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Effects of maternal nuclear genome on the timing of puberty in mice offspring

Zhou

Zhu

Guo

et al. 2007

Journal of Endocrinology

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The timing of puberty is a complex trait which is regulated by environmental and genetic factors, but the detailed regulatory mechanism remains elusive. Maternal nutrition administration during late gestation in rats revealed that the time of onset of puberty in daughter rats was influenced by the mother's nutritional and physiological status during the embryonic development period. In this study, the potential effects of the maternal nuclear genome on the timing of puberty of offspring were investigated. Two inbred strains of mice (C3H/HeJ (C3H) and C57BL/6J (B6)) were used to set up two pedigrees (direct and reciprocal crosses), and the timing of puberty in all these mice (parent, F1 and F2) was recorded (the females were assessed by vaginal opening (VO) and the males by balano preputial separation (BPS)). The results from data of 822 mice showed that: 1) in female mice, the heritability of the timing of puberty in direct and reciprocal crosses is 68 . 51% and 63 . 97% respectively; 2) in female mice, a significant difference in the timing of puberty is observed between B6 and C3H (PZ3 . 7!10 ), while such differences vanish in their male progenitor and progeny. The significant discrepancy between direct and reciprocal crosses in F1 but not in either cross of F2 hybrids reveals that the maternal nuclear genome has effects on the timing of puberty in mice progeny, probably through imprinting genes or the genes associated with intra-uterine physiological status.

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Early Puberty-Menarche After Precocious Pubarche: Relation to Prenatal Growth

Abstract: The link between prenatal growth restraint and early menarche is herewith extended to PP girls. In particular LBW-PP girls may become a target group for interventions directed toward normalization of pubertal onset and progression.

Cited by 164 publications

References 32 publications

Free testosterone and dehydroepiandrosterone sulfate serum levels in polycystic ovary syndrome women

Free testosterone and dehydroepiandrosterone sulfate serum levels in polycystic ovary syndrome women

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Effects of maternal nuclear genome on the timing of puberty in mice offspring

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