Early Pseudomonas aeruginosa predicts poorer pulmonary function in preschool children with cystic fibrosis

Aurora, Paul; Duncan, Julie; Lum, Sooky; Davies, Gwyneth; Wade, Angie; Stocks, Janet; Viviani, Laura; Raywood, Emma; Pao, C.; Ruiz, Gary; Bush, Andy

doi:10.1016/j.jcf.2022.04.013

Cited by 8 publications

(3 citation statements)

References 34 publications

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“…Pseudomonas aeruginosa was the most frequently found microorganism in both groups, and it is associated with a poor prognosis. 42 Nevertheless, there were no statistically significant differences between the groups, likely because of the small number of infected patients included in our study.…”

Section: Discussionmentioning

confidence: 62%

Should atelectasis be considered a pulmonary complication and indicator of poor prognosis in cystic fibrosis?

Martínez Redondo,

Carpio Segura,

Zamarrón De Lucas

et al. 2024

J Int Med Res

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Objective This study examined whether bronchoscopy leads to clinicoradiological improvement in cystic fibrosis (CF) and the predictive factors. The study also investigated whether pulmonary atelectasis is a poor prognostic factor in CF. Methods This multicenter, case–control, observational, retrospective study included two groups of patients with CF: a case group (patients with persistent atelectasis who were followed-up at least for 2 years) and a control group (patients without atelectasis matched 1:1 by sex and age [±3 years]). We recorded demographic data, lung function test results, pulmonary complications, comorbidities, treatments (including bronchoscopies, surgery and transplantation), and deaths. Results Each group included 55 patients (case group: 20 men, mean age 25.4 ± 10.4 years; control group: 20 men, mean age 26.1 ± 11.4 years). Bronchoscopy did not lead to clinicoradiological improvement. Allergic bronchopulmonary aspergillosis (ABPA) was more frequent in the case group. Patients in the case group more frequently used inhaled steroids, their pre-atelectasis lung function was statistically worse, and they had more exacerbations during follow-up. Conclusion Moderate-to-severe pulmonary disease and ABPA can favor atelectasis. Pulmonary atelectasis can be a poor prognostic factor in CF because it increases exacerbations. Despite our results, we recommend enhancing treatment, including bronchoscopy, to prevent persistent atelectasis.

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Section: Discussionmentioning

confidence: 62%

Should atelectasis be considered a pulmonary complication and indicator of poor prognosis in cystic fibrosis?

Martínez Redondo,

Carpio Segura,

Zamarrón De Lucas

et al. 2024

J Int Med Res

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“…Lung function outcomes were lower in those with intermittent private insurance and exclusively public insurance compared to those who always had private insurance, although no differences in BMI were seen 63 . In 67 infants with CF diagnosed via NBS, PA infection before 6 months of age was a highly predictive indicator for elevated preschool LCI 64 . Additionally, despite a normal CT scan at 1 year of age and normal PFTs at 2 years of age, LCI worsened between age 2 and preschool ages (3–6 years).…”

Section: Pulmonologymentioning

confidence: 86%

Cystic fibrosis year in review 2022

Kim,

Lyman,

Savant

2023

Pediatric Pulmonology

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Remarkable medical advancements have been made for people with cystic fibrosis (CF) in recent years, with an abundance of research continuing to be conducted worldwide. With concern for limitations in access to highly effective CFTR modulators, as well as the recent Coronavirus Disease‐19 pandemic, there has been a consistent effort to understand and improve CF screening, disease burden, diagnosis, and management. Our aim in this review is to present articles from 2022 with an emphasis on clinically relevant studies. We hope this will serve as a broad overview of the research published in the past year.

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“…The shift from intermittent to chronic infections is primarily linked to P. aeruginosa tendency to form biofilms [ 77 ]. The onset of antimicrobial resistance in the context of P. aeruginosa is not only associated to biofilm development; in fact, the pathogen demonstrates adaptability to its environment through some virulence factors and the creation of multi-drug-tolerant persister cells, dormant variants that randomly emerge in microbial populations [ 78 ]. These mechanisms often operate simultaneously, leading to resistance against nearly all available antibiotics.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Antimicrobial Resistance in Cystic Fibrosis

Vitiello,

Blasi,

Sabbatucci

et al. 2024

JCM

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The phenomenon of antimicrobial resistance (AMR) is a critical global health challenge, with prospects indicating its potential to become the leading cause of death worldwide in the coming years. Individuals with pre-existing conditions, such as neoplastic disease undergoing chemotherapy, those on immunosuppressive therapy, and individuals with rare diseases like cystic fibrosis (CF), face heightened challenges due to AMR. CF is a rare disease caused by a deficiency in the synthesis of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel protein, resulting in multi-organ clinical symptoms, particularly in the respiratory system. PwCF experience recurrent pulmonary exacerbations triggered by bacterial or viral infections, making them particularly vulnerable to the impact of AMR. This review delves into the complex relationship between AMR and climate dynamics, focusing on the unique challenges faced by individuals with CF. It discusses the methods employed to measure AMR, its global impact on antibiotic resistance, and the specific microbial communities present in the CF airway. The review also explores the intricacies of antimicrobial resistance within the context of cystic fibrosis, emphasizing the urgent need for research in this field.

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Early Pseudomonas aeruginosa predicts poorer pulmonary function in preschool children with cystic fibrosis

Cited by 8 publications

References 34 publications

Should atelectasis be considered a pulmonary complication and indicator of poor prognosis in cystic fibrosis?

Should atelectasis be considered a pulmonary complication and indicator of poor prognosis in cystic fibrosis?

Cystic fibrosis year in review 2022

The Impact of Antimicrobial Resistance in Cystic Fibrosis

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