Early Pregnancy and Endothelial Dysfunction

Abstract

The aim is to analyze the value of endothelial dysfunction markers during pregnancy. Materials and methods: We have examined 153 pregnant women to identify endothelial dysfunction markers of endothelin-1, nitrogen oxide (NO) that have been studied using immunoenzymometric sets for an uncomplicated and complicated pregnancy. Results: We found that the concentration of endothelin-1 repeatedly exceeded the rates in pregnant women with miscarriages than during physiological pregnancy. The diametrically opposite pattern concerns the level of nitrogen oxide. These changes in the markers of the functional state of the endothelin indicate the development of the dysfunction of this system in women with the pathology of pregnancy. Conclusions: Consequently, endothelial dysfunction can be considered to be one of the reasons for miscarriage in the examined women. Therefore, the definition of markers of endothelial dysfunction has prognostic value.

Endothelin-1 axes in the framework of predictive, preventive and personalised (3P) medicine

“…Furthermore, endothelial dysfunction, characterised by imbalances of vasoconstrictor/vasodilator factors, involves increases in blood coagulation potential (hypercoagulation) leading to uterine vessel vasoconstriction, platelet aggregation activation and resulting in final miscarriage [ 418 ]. Dubyk et al compared ET-1 and NO serum levels in pregnancies with a risk of miscarriage, spontaneous abortion and non-developing pregnancies versus physiological pregnancies [ 418 ]. They reported a significant increase in ET-1 and decreased NO levels in all groups compared to the control group.…”

“…They reported a significant increase in ET-1 and decreased NO levels in all groups compared to the control group. This indicated that endothelial dysfunction was likely the cause of miscarriage in these women, serving ET-1 and NO as potential markers for endothelial dysfunction [ 418 ].…”