Early postoperative enteral immunonutrition

Senkal, M.; Mumme, A.; Eickhoff, Ulrich; Geier, B.; Späth, G; Wulfert, Dietmar; Joosten, U.; Frei, Andreas; Kemen, M.

doi:10.1097/00003246-199709000-00015

Cited by 223 publications

(23 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Immunonutrition, which contains a combination of glutamine, arginine, n-3 fatty acids, and RNA, has been evaluated in numerous studies [13, 25, 29, 41, 43, 46, 47, 50, 51, 53, 54]. A recent meta-analysis assessed the impact of IN on postoperative complications, in particular infectious complications, length of hospital, stay and mortality in patients undergoing major GI surgery.…”

Section: Resultsmentioning

confidence: 99%

Perioperative Nutrition in Abdominal Surgery: Recommendations and Reality

Cerantola

Grass

Cristaudi

et al. 2011

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Introduction. Preoperative malnutrition is a major risk factor for increased postoperative morbidity and mortality. Definition and diagnosis of malnutrition and its treatment is still subject for controversy. Furthermore, practical implementation of nutrition-related guidelines is unknown. Methods. A review of the available literature and of current guidelines on perioperative nutrition was conducted. We focused on nutritional screening and perioperative nutrition in patients undergoing digestive surgery, and we assessed translation of recent guidelines in clinical practice. Results and Conclusions. Malnutrition is a well-recognized risk factor for poor postoperative outcome. The prevalence of malnutrition depends largely on its definition; about 40% of patients undergoing major surgery fulfil current diagnostic criteria of being at nutritional risk. The Nutritional Risk Score is a pragmatic and validated tool to identify patients who should benefit from nutritional support. Adequate nutritional intervention entails reduced (infectious) complications, hospital stay, and costs. Preoperative oral supplementation of a minimum of five days is preferable; depending on the patient and the type of surgery, immune-enhancing formulas are recommended. However, surgeons' compliance with evidence-based guidelines remains poor and efforts are necessary to implement routine nutritional screening and nutritional support.

show abstract

Section: Resultsmentioning

confidence: 99%

Perioperative Nutrition in Abdominal Surgery: Recommendations and Reality

Cerantola

Grass

Cristaudi

et al. 2011

Gastroenterology Research and Practice

View full text Add to dashboard Cite

show abstract

“…The most common reported beneficial effects of immunonutrition are reductions in the rate of postoperative infectious complications and the length of hospital stay [43, 46,85,86,87,88,89,90,91,92,93,94,95,96,97,98]. Moreover, a reduction in stoma fistula and improved surgical wound healing are other favorable outcomes reported [92, 99].…”

Section: Early Postoperative Nutritionmentioning

confidence: 99%

“…Moreover, a reduction in stoma fistula and improved surgical wound healing are other favorable outcomes reported [92, 99]. Some studies have also shown a cost-effectiveness of immunonutritional administration, related to the reduction in postoperative infectious complications and length of hospital stay [87, 90, 100]. …”

Section: Early Postoperative Nutritionmentioning

confidence: 99%

Perioperative Nutrition in Elective Gastrointestinal Surgery – Potential for Improvement?

et al. 2008

View full text Add to dashboard Cite

Nutritional concern is one of the most important issues to be addressed in the perioperative care given to gastrointestinal patients. Not at least, malnutrition may be detrimental and relate to postoperative morbidity. Perioperative nutritional management, integrated with other modern perioperative care policies, allows the establishment of multimodal strategies with an attempt to optimize the patients’ course of disease. The present review evaluates available data regarding pre- and postoperative nutrition, nutritional supplements, including immunonutrition, and their clinical role. It is to be concluded that pre- and postoperative prolonged fasting has no routine role in management. Instead, for example, early postoperative feeding administered perorally or enterally may reduce postoperative complications and length of hospital stay. There are also indications that perioperative immunonutrition may reduce postoperative infectious complications and length of hospital stay, though further studies in this field are needed.

show abstract

“…Senkal et al [83]confirmed that early postoperative enteral LA supplement (together with dietary nucleotides and omega-3 fatty acids) improves clinical outcome.…”

Section: Noncardiovascular Effectsmentioning

confidence: 99%

<i>L</i>-Arginine: Rediscovery in Progress

Tenenbaum¹,

Fisman²,

Motro³

1998

Cardiology

View full text Add to dashboard Cite

Since the recognition that L-arginine (LA) is the natural metabolic donor of nitric oxide, this amino acid has reached the medical spotlight. LA exerts favorable effects in the prevention and treatment of endothelial damage and the restoration of endothelial function in patients with cardiovascular risk factors (hypercholesterolemia, smoking, hypertension, diabetes and advanced age) or with several chronic cardiovascular disorders (coronary, peripheral and cerebral vascular disease, and mild-to-moderate heart failure). LA administration is likely to represent a potentially novel therapeutic strategy during angioplasty, coronary bypass grafting and cardiac transplantation. More conclusive research findings for the rediscovered role of this well-known substance merit close attention.

show abstract

Early postoperative enteral immunonutrition

Cited by 223 publications

References 15 publications

Perioperative Nutrition in Abdominal Surgery: Recommendations and Reality

Perioperative Nutrition in Abdominal Surgery: Recommendations and Reality

Perioperative Nutrition in Elective Gastrointestinal Surgery – Potential for Improvement?

<i>L</i>-Arginine: Rediscovery in Progress

Contact Info

Product

Resources

About