Early Postnatal Effects of Noopept and Piracetam on Declarative and Procedural Memory of Adult Male and Female Rats

Abstract

We studied the effect of a new nootropic dipeptide Noopept and reference nootropic preparation piracetam injected subcutaneously on days 8-20 of life on learning of alternative feeding response in a 6-arm-maze in male and female rats. Early postnatal administration of Noopept disturbed the dynamics of learning by parameters of declarative and procedural memory. Piracetam impaired learning by parameters of procedural, but not declarative memory (only in males). Both preparations decreased the ratio of successfully learned males (but not females). The observed effects were not associated with changes in locomotor activity.

Innovative mechanisms of action for pharmaceutical cognitive enhancement: A systematic review

“…However, these drugs have multiple modes of action and produce only weak AMPA receptor activation and it is unclear how significant their ampakine actions are in producing their positive effects. Animal studies suggest memory and wakefulness enhancement properties of several racetams (Barad et al, 1998;Grossman et al, 2011;Lelkes et al, 1998;Mondadori et al, 1986;Samartgis et al, 2012;Scheuer et al, 1999;Trofimov et al, 2005;Tushmalova et al, 1995). It is noteworthy that animal experiments focused on restoring age-impaired cognitive functions (Gualtieri et al, 2002).…”

Neuroenhancement in Healthy Adults, Part I: Pharmaceutical Cognitive Enhancement: A Systematic Review

“…Although animal studies suggest memory and wakefulness enhancement properties of several racetams [170][171][172][173][174][175][176][177], the effectiveness of piracetam or piracetam-like molecules was not explored in healthy adults to date. An explanation could be that all animal data focused on restoring age-impaired cognitive functions [11].…”