Early physical activity minimizes the adverse effects of a low-energy diet on growth and development parameters

Muniz, Gisélia de Santana; Silva, Amanda Marcelino Alves da; Cavalcante, Taisy Cinthia Ferro; França, Ana Karla da Silva; Ferraz, Karla Mônica; Nascimento, Elizabeth do

doi:10.1179/1476830512y.0000000037

Cited by 9 publications

(3 citation statements)

References 46 publications

(63 reference statements)

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“…P8 in rats corresponds to approximately 1-year-old children. 37 This research study adopted the 8-day-old SD pups’ early swimming training program established by Muniz et al 38 To confirm whether the rat model of ASD could complete the swimming training program, the early swimming intervention program was validated and refined. We extended the period of the training program from P52 to 60, and according to the record of rats’ swimming status, the duration of each training session was increased from 30 min to 40 min at P27-60, as shown in Figure 1 .…”

Section: Methodsmentioning

confidence: 99%

Effect of Early Swimming on the Behavior and Striatal Transcriptome of the Shank3 Knockout Rat Model of Autism

Meng¹,

Xu²,

Zhang³

et al. 2022

NDT

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Background Autism spectrum disorder (ASD) is a developmental disorder characterized by social behavior deficits and stereotyped behaviors in childhood that lacks satisfactory medical intervention. Early swimming intervention is a noninvasive method combining enriched environment and exercise, which has been proven to improve brain development in young children and to treat neurodevelopmental diseases. Methods In this study, we tested the autism-like behavior of rats with deletions in exons 11–21 of the Shank3 gene and evaluated the effect of early swimming intervention (from postnatal day 8 to 60) on the behavior of this animal model of autism. In addition, the transcriptomes of the striatal tissues of wild-type, Shank3 knockout and Shank3 knockout swimming groups rats were analyzed. Results Shank3 knockout rats exhibit core symptoms of autism, and early swimming improved the social and stereotyped behaviors in this autism rat model. Transcriptomics results revealed that compared to the wild-type group, 291 differentially expressed genes (DEGs) were identified in the striatum of the Shank3 knockout group. Compared to Shank3 knockout group, 534 DEGs were identified in the striatum of Shank3 knockout swimming group. The DEGs annotated by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway shows that the impacts of Shank3 deletion were primarily reflected in synaptic structure, development, morphology, receptor function and signaling, and swimming primarily changed the terms related to the synapses in the striatum of Shank3 knockout rats, including the morphology, structure, composition, development and regulation of synapses. Conclusion Early swimming intervention can ameliorate behavioral abnormalities caused by Shank3 knockout, by a mechanism that may involve the process of striatal synaptic development and should be further investigated.

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Section: Methodsmentioning

confidence: 99%

Effect of Early Swimming on the Behavior and Striatal Transcriptome of the Shank3 Knockout Rat Model of Autism

Meng¹,

Xu²,

Zhang³

et al. 2022

NDT

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“…The length longitudinal (LL, distance for nose to anus) was measured weekly from birth to the end of the experiment, containing the animal gently (Santana Muniz et al, 2013) was Brazilian Journal of Health Review, Curitiba, v. 5, n. 4, p. 13111-13129, jul./aug., 2022 measured with digital caliper (Starret ®, series 799, São Paulo, Brazil) with a 0.01mm precision.…”

Section: Somatic Growthmentioning

confidence: 99%

“…Offspring were housed in pairs (constituting a sample unit) and animal´s daily food consumption was determined by the difference between the amount of provide (50 to 60g) at the onset of the light phase and the amount of food remaining 24h later. Body and food weight was measured with a digital electronic scale was used, Marte XL 500, class II, maximum capacity 500g (smaller division 0.001g) (Santana Muniz et al, 2013)…”

Section: Measurement Of Food Intakementioning

confidence: 99%

Consequences on anthropometry and metabolism of offspring maintenance with low-protein diet since pregnancy to adult age / Consequências sobre a antropometria e o metabolismo em ratos submetidos a dieta com baixo teor de proteínas da gravidez até a idade adulta

Nascimento¹,

Neto²,

Araújo³

et al. 2022

Braz. J. Hea. Rev.

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The pre and early post natal is a period high susceptible to environmental insults for instance nutrition. There is a high metabolic demand necessary for the multiplication and differentiation of cells for the formation of tissues and organs and unbalanced diets affect metabolism at long term. The present study aimed to analyze physiological and metabolic parameters in male offspring submitted to the low protein diet in the perinatal life followed by a normoprotein diet or kept on the same maternal low protein diet after weaning. 12 female Wistar rats were matched with male of same strainand according maternal diet forming normoproteic and low-protein groups during gestation and lactation. At weaning three groups were randomly formed: CC (control-control), LP (low-protein-low protein) and LPC (low-protein-control). Somatic growth, feed intake, organ weight, biochemical parameters, liver fat, blood cell count and glucose tolerance test were analysed. The post-weaning "nutritional recovery" diet improved body mass and longitudinal length. But, the maintenance with low protein diet post weaning caused weight and length deficiency (P<0.001). Other parameters such as food intake, murinometric measurements, fasting gliscemia, visceral fat, organ weight, OGTT and biochemical parameters observed in the LPC were similar to CC. The LP groups caused lower area under the glycemic curve, lower visceral fat, but similar blood count, tibial growth and liver fat compared to control. The parameters evaluated in offspring submitted to nutritional recovery corroborate previous study, but the maintenance of offspring with low protein diet minimizes catch-up growth, but alters metabolic response to glucose.

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Short- and long-term effects of a maternal low-energy diet ad libitum during gestation and/or lactation on physiological parameters of mothers and male offspring

et al. 2014

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Early physical activity minimizes the adverse effects of a low-energy diet on growth and development parameters

Abstract: Taken together, we suggest that physical activity in water acts as a beneficial factor in LE diets of dams during the perinatal period. Further study is necessary to investigate the role of physical activity for adaptation against adverse nutritional stimuli.

Cited by 9 publications

References 46 publications

Effect of Early Swimming on the Behavior and Striatal Transcriptome of the Shank3 Knockout Rat Model of Autism

Effect of Early Swimming on the Behavior and Striatal Transcriptome of the Shank3 Knockout Rat Model of Autism

Consequences on anthropometry and metabolism of offspring maintenance with low-protein diet since pregnancy to adult age / Consequências sobre a antropometria e o metabolismo em ratos submetidos a dieta com baixo teor de proteínas da gravidez até a idade adulta

Short- and long-term effects of a maternal low-energy diet ad libitum during gestation and/or lactation on physiological parameters of mothers and male offspring

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