Early Phase Clinical Trials: Referral Barriers and Promoters among Physicians

Ramirez, Amelie G.; Chalela, Patricia; Suarez, Lucina; Muñoz, Edgar; Pollock, Brad H.; Weitman, Steven; Gallion, Kipling J.

doi:10.4172/2161-0711.1000173

Cited by 13 publications

(3 citation statements)

References 33 publications

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“…Published research related to efforts to increase minority ethnicity participation in CCT includes cross-sectional studies among healthy community participants (Langford, Resnicow, & An, 2010; Trauth et al, 2005), diagnosed patients (Byrne et al, 2014), clinical providers (Michaels, Blakeney, Langford, & Ford, 2014; Ramirez et al, 2013), and biorepository facilities (Simon et al, 2014), as well as interventions among cancer patients (Fracasso et al, 2013; Quinn et al, 2013; Vicini et al, 2011), ethnic media audiences (Alexander, Kwon, Strecher, & Bartholomew, 2013), and community leaders, providers, and researchers (Michaels et al, 2011). We are aware of only one other report on a single-session intervention designed to educate ethnic minority, healthy populations about CCT, which focused on Chinese Americans (Ma et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Adaptation of a Cancer Clinical Trials Education Program for African American and Latina/o Community Members

et al. 2015

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The pilot study reported in this article culturally and linguistically adapted an educational intervention to promote cancer clinical trials (CCTs) participation among Latinas/os and African Americans. The single-session slide presentation with embedded videos, originally developed through a campus–community partnership in Southern California, was chosen for adaptation because it was perceived to fit the CORRECT model of innovation (credible, observable, relevant, relatively advantageous, easy to understand, compatible, and testable) and because of the potential to customize any components not identified as core, allowing them to be revised for cultural and linguistic alignment in New York City. Most of the 143 community participants (76.2%) were female; most (54.6%) were older than 59 years. More than half (78.3%) preferred to speak English or were bilingual in English and Spanish. A large proportion (41.3%) had not completed high school. Knowledge and perceived benefits and barriers regarding CCT showed small, though statistically significant, increases. There were no statistically significant group differences for changes in mean knowledge, perceived benefits, or perceived barriers when examined by ethnicity, education level, language, or other included sociodemographic variables. However, a small, but statistically significant difference in perceived barriers was observed when examined by country of origin, with the foreign born score worsening 0.08 points (SD = 0.47, p = .007) on the 5-point Likert-type scale administered posteducation compared to preeducation. Participants’ open-ended comments demonstrated the acceptability of the topic and intervention. This adaptation resulted in an intervention with the potential to educate African American and Latina/o general community members in a new geographic region about the purpose, methods, and benefits of CCTs.

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Section: Discussionmentioning

confidence: 99%

Adaptation of a Cancer Clinical Trials Education Program for African American and Latina/o Community Members

et al. 2015

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“…Two of our primary recruitment resources were Online/internet advertisements and Partners healthcare network (hospital, website or rally). This is indeed a barrier for recruitment as clinicians usually do not have time in their full schedules to explain and provide information on clinical trials [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Recruitment characteristics and non-adherence associated factors of fibromyalgia patients in a randomized clinical trial: A retrospective survival analysis

Cardenas-Rojas

Castelo-Branco

Pacheco‐Barrios

et al. 2021

Contemporary Clinical Trials Communications

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“…Addressing physician-level barriers to referring patients, such as physicians’ lack of awareness of available trials, concern of losing patients, and lack of time [ 23 ], is imperative to adequate patient care. Additionally, current referral practices encompassing preappointment communication regarding available trials, required testing and records, patient functional status, and preferences must be honed among academic and referring community centers.…”

Section: Introductionmentioning

confidence: 99%

Adapting and Developing an Academic and Community Practice Collaborative Care Model for Metastatic Breast Cancer Care (Project ADAPT): Protocol for an Implementation Science–Based Study

et al. 2022

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Background Metastatic breast cancer (MBC) remains incurable despite significant treatment advances. Coordinating care for patients with MBC can be challenging given the various treatment options, available clinical trials, and frequent need for ancillary services. To optimize MBC care, we designed a project for adapting and developing an academic and community practice collaborative care model for MBC care (Project ADAPT), based on the Ending Metastatic Breast Cancer for Everyone (EMBRACE) program developed at Dana Farber Cancer Institute. Objective We aim to describe the implementation science–based study design and innovative components of Project ADAPT. Methods Project ADAPT uses the Dynamic Adaptation Process informed by the Exploration, Preparation, Implementation, Sustainment framework. Washington University School of Medicine (WUSM) partnered with 3 community hospitals in the St. Louis region covering rural and urban settings. The exploration and preparation phases provide patient and provider feedback on current referral practices to finalize the approach for the implementation phase. At the implementation phase, we will enroll patients with MBC at these 3 community sites to evaluate potential collaborative care at WUSM and assess the impact of this collaborative care model on referral satisfaction and acceptability for patients with MBC and their providers. Patients may then return to their community site for care or continue to receive part of their care at WUSM. We are incorporating virtual and digital health strategies to improve MBC care coordination in order to minimize patient burden. Results The exploration phase is ongoing. As of August 2021, we have recruited 21 patient and provider participants to complete surveys of the current collaborative care process at WUSM. Using a 2-tailed paired t test, 44 patients (including 10 patients from the exploration phase) and 32 oncologists are required to detect an effect size of 0.5 with 80% power at a level of significance of .05. Throughout this phase and in preparation for the implementation phase, we have iteratively updated and refined our surveys for the implementation phase based on testing of our data collection instruments. Our partner sites are in various stages of the single institutional review board (IRB) approval process. We have ongoing engagement with all partner sites, which has helped solidify our participant recruitment strategies and design patient-friendly recruitment materials. In addition, we have included a patient advocate on the research team. Members of the research team have launched a single IRB Support Network at WUSM to create a repository of the single IRB procedures in order to streamline the partner site onboarding process and facilitate enhanced collaboration across institutions. Conclusions With this robust model, we expect that patients with MBC will receive optimal care regardless of geographical location and the model will improve patient and provider experiences when navigating the health system. International Registered Report Identifier (IRRID) DERR1-10.2196/35736

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Early Phase Clinical Trials: Referral Barriers and Promoters among Physicians

Cited by 13 publications

References 33 publications

Adaptation of a Cancer Clinical Trials Education Program for African American and Latina/o Community Members

Adaptation of a Cancer Clinical Trials Education Program for African American and Latina/o Community Members

Recruitment characteristics and non-adherence associated factors of fibromyalgia patients in a randomized clinical trial: A retrospective survival analysis

Adapting and Developing an Academic and Community Practice Collaborative Care Model for Metastatic Breast Cancer Care (Project ADAPT): Protocol for an Implementation Science–Based Study

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