Early opacification of silicone intraocular lenses: Laboratory analyses of 6 explants

Werner, Liliana; Dornelles, Fábio; Hilgert, Christiana Rebello; Botelho, Fernando Mendes; Conte, Paulo F.; Andrenyak, David M.; Mamalis, Nick; Olson, Randall J.

doi:10.1016/j.jcrs.2005.12.137

Cited by 19 publications

(14 citation statements)

References 24 publications

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“…Two of these cases had been reported in collaboration with Hilgert et al, 8,9 who had a total of 4 similar cases ( Figure 3). The IOLs were implanted in 4 different locations in Brazil and in France.…”

Section: Early Postoperative Iol Opacification/ Discoloration Early Omentioning

confidence: 78%

Causes of intraocular lens opacification or discoloration

Werner¹

2007

Journal of Cataract and Refractive Surgery

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Various pathologic processes may lead to clinically significant opacification or discoloration of the optic component of intraocular lenses (IOLs) manufactured from different biomaterials and in different designs. Factors such as the patient's associated conditions, the manufacturing process, the method of IOL storage, the surgical technique and adjuvants, or a combination of these may be involved. The complication may be observed intraoperatively or postoperatively from a few hours after implantation to many years after surgery, depending on the processes involved. Based on a review of the literature as well as our own laboratory analyses, the following types of processes were identified: formation of deposits/precipitates on the IOL surface or within the IOL substance; opacification by excess influx of water in hydrophobic materials; direct discoloration by capsular dyes or medications; coating by substances such as ophthalmic ointment and silicone oil; and a slow, progressive degradation of the IOL biomaterial.

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Section: Early Postoperative Iol Opacification/ Discoloration Early Omentioning

confidence: 78%

Causes of intraocular lens opacification or discoloration

Werner¹

2007

Journal of Cataract and Refractive Surgery

Self Cite

151

101

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“…We reported significant opacification observed as early as a few hours after implantation because cleaning agents and fumigants used in storage areas apparently penetrated the semipermeable packages contaminating the silicone IOLs preoperatively, causing changes that lead to influx of water and therefore opacification of the IOL optic ( Figure 14). 59,60 Other studies have described similar cases but without a clear history of preoperative contamination of the IOLs by exogenous molecules. 61,62 Brown discoloration and central haze in silicone IOLs observed from 15 to 60 months after implantation were described in the early 1990s.…”

Section: Glistenings In Silicone Intraocular Lensesmentioning

confidence: 93%

Glistenings and surface light scattering in intraocular lenses

Werner¹

2010

Journal of Cataract and Refractive Surgery

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165

161

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“…The B63d disks became opaque white‐yellow at the end of the surgery and fibrin deposit was observed after 1 d (Figure D). These effects may be due to various types of processes, intraoperative or early postoperative such as surgical techniques or adjuvants, chemical contamination induced injury such as povidone iodine, calcification, interactions with adsorbed proteins likely serum albumin, presence of sodium hyaluronate (added during surgery), and alteration of the balance between procoagulant and anticoagulant reactions due to coumarin . During cataract surgery, the protein concentration and cell level in the aqueous humor increase because of the blood–aqueous barrier (BAB) breakdown.…”

Section: Resultsmentioning

confidence: 99%

Photoreversibility and Biocompatibility of Polydimethylsiloxane‐Coumarin as Adjustable Intraocular Lens Material

Jellali

Bertrand

Alexandre

et al. 2017

Macromolecular Bioscience

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Polydimethylsiloxane (PDMS) constitutes an interesting material for a variety of biomedical applications, especially as intraocular lenses (IOLs), for its excellent transparency. In this work, a photoreversible PDMS-coumarin network, whose shape and properties can be adjusted postoperatively in a noninvasive manner, is developed. The synthesis of PDMS-coumarin is achieved by amidation of a coumarin acid chloride derivative with amine-functionalized PDMSs. Under exposure of λ > 300 nm, these polymers can be cured by dimerization of coumarin. The cured polymers can be uncrosslinked via photocleavage of cyclobutane dimers upon illumination at λ < 290 nm. The diffusion of linear PDMSs in a crosslinked network and the controlled shape modification are studied, which demonstrate that these polymers are good candidates for adjustable IOL application. IOL disks prepared from these materials show high hydrophobicity and good transparency. In vitro cytotoxicity, lens epithelial cell adhesion assays, and rabbit host reaction against implanted disks demonstrate the biocompatibility of the polymer.

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Early opacification of silicone intraocular lenses: Laboratory analyses of 6 explants

Cited by 19 publications

References 24 publications

Causes of intraocular lens opacification or discoloration

Causes of intraocular lens opacification or discoloration

Glistenings and surface light scattering in intraocular lenses

Photoreversibility and Biocompatibility of Polydimethylsiloxane‐Coumarin as Adjustable Intraocular Lens Material

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