Early onset preeclampsia and second trimester serum markers

Abstract

The levels of inhibin A, PlGF, and endoglin in the second trimester can be combined using a predictive model to provide individualized risk estimates for early onset preeclampsia.

Repeated Measures of Placental Growth Factor, Placental Protein 13, and A Disintegrin and Metalloprotease 12 at First and Second Trimesters for Preeclampsia Screening

“…The addition of maternal serum or uterine artery Doppler markers improves the prediction of preeclampsia especially in nulliparous women. [7][8][9][10] Research about screening by first-trimester markers alone, 11,12 second-trimester markers alone, 13 and combining first-trimester biomarkers and second-trimester uterine artery Doppler indices [14][15][16][17][18] have shown an improvement of screening performance compared with screening by isolated markers. But combining clinical data and biochemical markers in the first trimester failed to identify a model that could have clinical utility for predicting preeclampsia in an unselected population.…”

Risks for Preeclampsia and Small for Gestational Age: Predictive Values of Placental Growth Factor, Soluble fms-like Tyrosine Kinase-1, and Inhibin A in Singleton and Multiple-Gestation Pregnancies

“…3 The earlier the onset of the preeclampsia, the more altered the biomarkers levels. [6][7][8][9][10][11][12] This should be assessed in further studies on multiplegestation pregnancies stratified by severity of preeclampsia.…”

“…onset of the disease and are correlated to severity and early onset of the disease. [6][7][8][9][10][11][12] In women with subsequent preeclampsia, low PlGF levels have been observed as early as in the first trimester, and sFlt-1 levels might begin to rise 5 weeks before the onset of the disease. 13 Therefore, in the second trimester, the ratio of sFlt-1 to PlGF appears to be a better marker of preeclampsia than either measure alone.…”

“…6,7 Inhibin A is a placental protein used for Down's syndrome screening, and its serum level is elevated among women who will subsequently develop preeclampsia and SGA. 8,11,14,15 In uncomplicated pregnancies, circulating inhibin A, sFlt1, and PlGF levels are higher in women with multiple gestations compared with women with singleton pregnancies. [16][17][18] In multiple gestations, PlGF and sFlt-1 serum levels, but not inhibin A, have been studied in small cohorts comparing preeclamptic pregnancies and controls.…”

Screening for pre-eclampsia using serum placental growth factor and endoglin with Down's syndrome Quadruple test markers

“…4 Of the antiangiogenic soluble receptor components, endoglin has been shown to be the most useful in predicting the development of pre-eclampsia, being, on average, 21% higher in women who develop pre-eclampsia compared with women who do not. 5 PlGF has also been shown to be useful, being on average 40% lower in women who develop pre-eclampsia compared with women who do not. 5 We here combine early second-trimester PlGF and endoglin values with second-trimester serum markers for Down's syndrome (alphafetoprotein [AFP], unconjugated oestriol [uE 3 ], human chorionic gonadotrophin [hCG] [total or free b] and inhibin-A) to assess the pre-eclampsia screening performance of combinations of these markers.…”