Risks for Preeclampsia and Small for Gestational Age: Predictive Values of Placental Growth Factor, Soluble fms-like Tyrosine Kinase-1, and Inhibin A in Singleton and Multiple-Gestation Pregnancies

Boucoiran, Isabelle; Thissier-Levy, Sarah; Wu, Yuquan; Wei, Shuqin; Luo, Zhong‐Cheng; Delvin, Edgard; Fraser, William D.; Audibert, François

doi:10.1055/s-0032-1329691

Cited by 17 publications

(15 citation statements)

References 21 publications

(45 reference statements)

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“…A good biomarker for PE remains elusive and even angiogenic factors such as soluble endoglin and sFlt-1 both minimally impact prediction when examined against other clinical risk factors. 36–39 …”

Section: Discussionmentioning

confidence: 99%

Increased Levels of Copeptin Before Clinical Diagnosis of Preeclampsia

et al. 2014

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Copeptin, a surrogate biomarker of vasopressin, has been associated with renal function decline and may serve as a useful early biomarker for preeclampsia. We measured serum copeptin using samples collected longitudinally during pregnancy among unaffected controls (n=136) and cases of preeclampsia (n=169), gestational diabetes (n=92), gestational hypertension (n=101) and preterm birth (n=86) in the Calcium for Preeclampsia Prevention trial (1992–1995). Preeclampsia and gestational hypertension were defined as having a diastolic blood pressure greater than or equal to 90 millimeters of mercury on two occasions with and without proteinuria, respectively. The risk of pregnancy complications associated with copeptin was estimated by logistic regression adjusting for maternal age, race, body-mass index, insurance status, marital status, current smoking, and clinical site. Baseline copeptin levels, at mean 16 weeks of gestation, were associated with increased preeclampsia risk (adjusted odds ratios and 95% confidence interval being 1.55 per log unit; 1.03–2.31) compared to controls (p=0.03). The association was stronger among cases diagnosed before 37 weeks (1.86; 1.08–3.20) than those diagnosed later (1.45; 0.91–2.32). Copeptin levels rose with increasing gestational age in both cases and controls but remained significantly higher among those who were diagnosed with preeclampsia. Differences in levels of copeptin between cases and controls became more apparent closer to time of diagnosis. No significant associations were found for gestational hypertension without proteinuria, gestational diabetes, or preterm birth without preeclampsia. Copeptin levels are elevated in pregnant women prior to diagnosis of preeclampsia with elevation specific to this pregnancy complication rather than hypertension alone.

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Section: Discussionmentioning

confidence: 99%

Increased Levels of Copeptin Before Clinical Diagnosis of Preeclampsia

et al. 2014

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“…Saleh et al found a similar relationship only in a group unaffected by PE, while, in the PE group, no significant differences were observed [47]. PlGF concentrations were also higher in twins compared to singletons [33,37,38,41,44,46,47]. Dröge et al and Saleh et al reported PlGF levels to be higher in the group of preeclamptic women with a twin gestation in comparison with women with a singleton pregnancy [41,47], whereas Francisco et al observed higher PlGF concentrations only in dichorionic twins [46].…”

Section: Differences In Serum Concentrations Of Sflt-1 Plgf and Senmentioning

confidence: 91%

“…Two other studies did not include singleton pregnancies [35,45], and, in the third one, no such comparisons were made [40]. sFlt-1 maternal serum levels were reported to be statistically higher in women with twin pregnancies in comparison with singleton gestations [33,37,38,41,47]. Saleh et al found a similar relationship only in a group unaffected by PE, while, in the PE group, no significant differences were observed [47].…”

Section: Differences In Serum Concentrations Of Sflt-1 Plgf and Senmentioning

confidence: 97%

“…Hence, differences in their concentrations between singleton and twin gestations were hypothesized. Seven out of ten papers included in this systematic review reported such differences [33,37,38,41,44,46,47]. Two other studies did not include singleton pregnancies [35,45], and, in the third one, no such comparisons were made [40].…”

Section: Differences In Serum Concentrations Of Sflt-1 Plgf and Senmentioning

confidence: 99%

“…This, with a high probability, indicated a substantially higher bias risk than the original study. Another possible source of bias for this review could be the fact that two of the included studies defined the study group as "multiple gestation", without specifying whether they were only twin pregnancies, and, in addition, the study by Boucoiran et al covered also five triplets [33,38,40]. Nevertheless, the authors assumed that this should not be a source of a major bias for this review.…”

Section: Risk Of Bias Assessment and Limitationsmentioning

confidence: 99%

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Maternal Serum Placental Growth Factor, Soluble Fms-Like Tyrosine Kinase-1, and Soluble Endoglin in Twin Gestations and the Risk of Preeclampsia—A Systematic Review

Kosińska-Kaczyńska

Zgliczyńska

Kozłowski

et al. 2020

JCM

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Multiple gestation is one of the key risk factors for the occurrence of preeclampsia (PE). Soluble fms-like tyrosine kinase-1, placental growth factor, and soluble endoglin are molecules involved in the process of angiogenesis with a proven role in the pathogenesis of PE. The aim of the review was to summarize available data on maternal serum levels of the above-mentioned factors and their usefulness in predicting PE in twin pregnancies. Only original research articles written in English were considered eligible. Reviews, chapters, case studies, conference papers, experts’ opinions, editorials, and letters were excluded from the analysis. No publication date limitations were imposed. The systematic literature search using PubMed/MEDLINE, Scopus, Embase, and Cochrane Library databases identified 338 articles, 10 of which were included in the final qualitative analyses. The included studies showed significant differences in maternal serum levels of the discussed factors between women with twin pregnancies with PE and those who did not develop PE, and their promising performance in predicting PE, alone or in combination with other factors. The identification of the most effective algorithms, their prompt introduction to the clinical practice, and further assessment of the real-life performance should become a priority.

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