Early Onset of Regional Intestinal Ischemia Can Be Detected with Carbon Dioxide Tension Measurement Inside the Peritoneal Cavity

Knichwitz, Gisbert; Brussel, Thomas Van; Reinhold, P.; Schaumann, Frank; Richter, K; Aken, Hugo Van

doi:10.1213/00000539-200011000-00026

Cited by 7 publications

(5 citation statements)

References 10 publications

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“…Intraperitoneal tonometric partial pressure of carbon dioxide ( P CO 2 ) is more sensitive to circulatory changes than intraluminal P CO 2 31, and early regional intestinal ischaemia overlooked by conventional gastric tonometry can be detected by intraperitoneal carbon dioxide tension measurements7. In agreement with the present results, Ungerstedt et al 23 demonstrated that local ischaemia of 30 cm small bowel could be detected using an intraperitoneal catheter placed alongside the ischaemic bowel in the peritoneal cavity, and showed similar changes in metabolites.…”

Section: Discussionsupporting

confidence: 88%

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Intraperitoneal and intraluminal microdialysis in the detection of experimental regional intestinal ischaemia

Sommer

Larsen

2004

British Journal of Surgery

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Section: Discussionsupporting

confidence: 88%

“…In most surgical departments the diagnosis of intestinal ischaemia still relies on clinical symptoms and examination, despite their low accuracy5, 6. Furthermore, biochemical changes may be localized in specific segments of the gut in patients with regional intestinal ischaemia, making diagnosis difficult7.…”

Section: Introductionmentioning

confidence: 99%

Intraperitoneal and intraluminal microdialysis in the detection of experimental regional intestinal ischaemia

Sommer

Larsen

2004

British Journal of Surgery

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“…The model herewith described was adapted from an existent, successful, large pig model of ischemia previously described by this group 13 – 15 . Twelve 1-year-old female domestic pigs were fed on a standard diet and fasted overnight and randomised into the different groups.…”

Section: Methodsmentioning

confidence: 99%

Intraluminal oxygen can keep small bowel mucosa intact in a segmental ischemia model

Trentadue,

Mensink,

Kruse

et al. 2024

Sci Rep

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Intestinal preservation for transplantation is accompanied by hypoperfusion with long periods of ischemia with total blood cessation and absolute withdrawal of oxygen leading to structural damage. The application of intraluminal oxygen has been successfully tested in small-animal series during storage and transport of the organ but have been so far clinically unrelatable. In this study, we tested whether a simple and clinically approachable method of intraluminal oxygen application could prevent ischemic damage in a large animal model, during warm ischemia time. We utilised a local no-flow ischemia model of the small intestine in pigs. A low-flow and high-pressure intraluminal oxygen deliverance system was applied in 6 pigs and 6 pigs served as a control group. Mucosal histopathology, hypoxia and barrier markers were evaluated after two hours of no-flow conditions, in both treatment and sham groups, and in healthy tissue. Macro- and microscopically, the luminal oxygen delivered treatment group showed preserved small bowel’s appearance, viability, and mucosal integrity. A gradual deterioration of histopathology and barrier markers and increase in hypoxia-inducible factor 1-α expression towards the sites most distant from the oxygen application was observed. Intraluminal low-flow, high oxygen delivery can preserve the intestinal mucosa during total ischemia of the small intestine. This finding can be incorporated in methods to overcome small bowel ischemia and improve intestinal preservation for transplantation.

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“…The model herewith described was developed further from an existent, successful, large pig model of ischemia previously described by this group (13)(14)(15). Twelve 1-year-old female domestic pigs were fed on a standard diet and fasted overnight and randomised into the different groups.…”

Section: Animal Preparationmentioning

confidence: 99%

Intraluminal oxygen can keep small bowel mucosa intact in a segmental ischemia model

Trentadue,

Mensink,

Kruse

et al. 2023

Preprint

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Background. Intestinal preservation for transplantation is accompanied by hypoperfusion with long periods of ischemia with total blood cessation and absolute withdrawal of oxygen leading to structural damage. The application of intraluminal oxygen has been successfully tested in small-animal series during storage and transport of the organ but have been so far clinically unrelatable. In this study, we tested whether a simple and clinically approachable method of intraluminal oxygen application could prevent ischemic damage in a large animal model, during warm ischemia time. Methods. We utilised a local no-flow ischemia model of the small intestine in pigs. A low-flow and high-pressure intraluminal oxygen deliverance system was applied in 6 pigs and 6 pigs served as a control group. Mucosal histopathology, hypoxia and barrier markers were evaluated after two hours of no-flow conditions, in both treatment and sham groups, and in healthy tissue. Results. Macro- and microscopically, the luminal oxygen delivered treatment group showed preserved small bowel’s appearance, viability, and mucosal integrity. A gradual deterioration of histopathology and barrier markers and increase in hypoxia-inducible factor 1-α expression towards the sites most distant from the oxygen application was observed. Conclusions. Intraluminal low-flow, high oxygen delivery can preserve the intestinal mucosa during total ischemia of the small intestine. This finding can be incorporated in methods to overcome small bowel ischemia and improve intestinal preservation for transplantation.

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Early Onset of Regional Intestinal Ischemia Can Be Detected with Carbon Dioxide Tension Measurement Inside the Peritoneal Cavity

Cited by 7 publications

References 10 publications

Intraperitoneal and intraluminal microdialysis in the detection of experimental regional intestinal ischaemia

Intraperitoneal and intraluminal microdialysis in the detection of experimental regional intestinal ischaemia

Intraluminal oxygen can keep small bowel mucosa intact in a segmental ischemia model

Intraluminal oxygen can keep small bowel mucosa intact in a segmental ischemia model

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