Early onset neonatal meningitis in Australia and New Zealand, 1992-2002

May, Meryta; Daley, Andrew J; Donath, Susan; Isaacs, David

doi:10.1136/adc.2004.066134

Cited by 87 publications

(65 citation statements)

References 13 publications

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“…Western Pacific Angstetra et al 65 Daley et al 66 May et al 67 Tiskumara et al 62 Tiskumara et al 62 Kim et al 68 Niduvaje et al 69 Subtotal (I 2 =54·7%, p=0·039)…”

Section: Eastern Mediterraneanmentioning

confidence: 99%

Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis

Edmond¹,

Kortsalioudaki²,

Scott³

et al. 2012

The Lancet

524

457

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SummaryBackground Despite widespread use of intrapartum antibiotic prophylaxis, group B streptococcus remains a leading cause of morbidity and mortality in infants in Europe, the Americas, and Australia. However, estimates of disease burden in many countries outside of these regions is not available. We aimed to examine the current global burden of invasive disease and the serotype distribution of group B streptococcus isolates.

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“…Western Pacific Angstetra et al 65 Daley et al 66 May et al 67 Tiskumara et al 62 Tiskumara et al 62 Kim et al 68 Niduvaje et al 69 Subtotal (I 2 =54·7%, p=0·039)…”

Section: Eastern Mediterraneanmentioning

confidence: 99%

Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis

Edmond¹,

Kortsalioudaki²,

Scott³

et al. 2012

The Lancet

524

457

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“…39 However, in bacteremic infants, the incidence of meningitis may be as high as 23%. 40,41 Blood culture alone cannot be used to decide who needs a lumbar puncture, because blood cultures can be negative in up to 38% of infants with meningitis. 42,43 The lumbar puncture should be performed in any infant with a positive blood culture, infants whose clinical course or laboratory data strongly suggest bacterial sepsis, and infants who initially worsen with antimicrobial therapy.…”

Section: Lumbar Puncturementioning

confidence: 99%

Management of Neonates With Suspected or Proven Early-Onset Bacterial Sepsis

Polin¹,

Newborn²

2012

Pediatrics

679

433

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With improved obstetrical management and evidence-based use of intrapartum antimicrobial therapy, early-onset neonatal sepsis is becoming less frequent. However, early-onset sepsis remains one of the most common causes of neonatal morbidity and mortality in the preterm population. The identification of neonates at risk for early-onset sepsis is frequently based on a constellation of perinatal risk factors that are neither sensitive nor specific. Furthermore, diagnostic tests for neonatal sepsis have a poor positive predictive accuracy. As a result, clinicians often treat well-appearing infants for extended periods of time, even when bacterial cultures are negative. The optimal treatment of infants with suspected early-onset sepsis is broad-spectrum antimicrobial agents (ampicillin and an aminoglycoside). Once a pathogen is identified, antimicrobial therapy should be narrowed (unless synergism is needed). Recent data suggest an association between prolonged empirical treatment of preterm infants (≥5 days) with broad-spectrum antibiotics and higher risks of late onset sepsis, necrotizing enterocolitis, and mortality. To reduce these risks, antimicrobial therapy should be discontinued at 48 hours in clinical situations in which the probability of sepsis is low. The purpose of this clinical report is to provide a practical and, when possible, evidence-based approach to the management of infants with suspected or proven early-onset sepsis. Pediatrics

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“…ExPEC strains do not produce enteric disease; however, they can asymptomatically colonize the intestinal tract of humans and warm-blooded animals and may be the predominant strains in healthy individuals. ExPEC have acquired various virulence factors that allow the induction, under favorable circumstances, of a wide range of extraintestinal infections in humans and poultry, including bacteremia, urinary tract infections, neonatal meningitidis, respiratory tract infections, and septicemia (19,28,41,47,48,54). ExPEC strains of avian origin are phylogenetically linked with strains isolated from normally sterile extraintestinal body sites of humans, with which they share numerous virulence factors.…”

mentioning

confidence: 99%

A Metabolic Operon in Extraintestinal PathogenicEscherichia coliPromotes Fitness under Stressful Conditions and Invasion of Eukaryotic Cells

et al. 2009

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We identified a carbohydrate metabolic operon (frz) that is highly associated with extraintestinal pathogenic Escherichia coli (ExPEC) strains. The frz operon codes for three subunits of a phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) transporter of the fructose subfamily, for a transcriptional activator of PTSs of the MgA family, for two type II ketose-1,6-bisphosphate aldolases, for a sugar-specific kinase (repressor, open reading frame, kinase family [ROK]), and for a protein of the cupin superfamily. We proved that the frz operon promotes bacterial fitness under stressful conditions, such as oxygen restriction, late stationary phase of growth, or growth in serum or in the intestinal tract. Furthermore, we showed that frz is involved in adherence to and internalization in human type II pneumocytes, human enterocytes, and chicken liver cells by favoring the ON orientation of the fim operon promoter and thus acting on the expression of type 1 fimbriae, which are the major ExPEC adhesins. Both the PTS activator and the metabolic enzymes encoded by the frz operon are involved in these phenotypes.

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Early onset neonatal meningitis in Australia and New Zealand, 1992-2002

Cited by 87 publications

References 13 publications

Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis

Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis

Management of Neonates With Suspected or Proven Early-Onset Bacterial Sepsis

A Metabolic Operon in Extraintestinal PathogenicEscherichia coliPromotes Fitness under Stressful Conditions and Invasion of Eukaryotic Cells

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