Early-onset acquired epileptic aphasia (Landau–Kleffner syndrome, LKS) and regressive autistic disorders with epileptic EEG abnormalities: The continuing debate

Landau Kleffner Syndrome and Misdiagnosis of Autism Spectrum Disorder: A Mini-Review

“…27,[37][38][39][40] In addition to formerly discussed studies, some other showing that antiepileptic medications can have a positive impact on behavior, 38,41 and no studies have yet demonstrated that treatment of epileptic disorders positively impact social, language, cognitive, or behavioral outcomes. 6,[26][27][28][29][30][31][32][33][34][35][36][37] …”

“…7,14 Since the original report by Landau and Kleffner in 1957, several cases of this syndrome are reported. 6 Commonly, LKS presents in children aged 2-8 years, with a peak between 5 and 7 years. The syndrome is more prevalent in in boys compared to girls.…”

“…28 Here is a point; loss of word and lack of language is more and more remarkable than the loss of social skills related to language, even if these skills starts prior to word loss. 29 Many children with primary diagnosis of autism, finally diagnosed as early LKS. The disease identification and final diagnosis is based on clinical judgments, EEG results, symptoms fluctuations and recurrences and there is a little place on a detailed analysis of both the linguistic and behavioral symptoms 30,31 Autism behavior might be a reflective of language loss in these patients or even could be a result of developmental deficit following the epileptic activities which involves both language and "social brain".…”

Landau-Kleffners syndrom

“…Alle typer ervervet afasi (for eksempelvis forårsaket av cerebrale skader, svulster eller infeksjoner), mutisme, laerevansker og hør-selstap er andre aktuelle differensialdiagnoser (13).…”

Landau-Kleffner Syndrome and Swearing

“…(Chez et al, 2006) The assumption that epileptic seizures and the acquired speech and comprehension disorders may correlate, is not confirmed. Nevertheless, some researches are thought that the epileptic activity may play a crucial role in the language disorders (Deonna & Roulet-Perez, 2010;Pearl et al, 2001). …”