Landau-Kleffners syndrom

Tuft, Mia; Årva, Marte; Bjørnvold, Marit; Wilson, John; Nakken, Karl Otto

doi:10.4045/tidsskr.15.0162

Cited by 8 publications

(1 citation statement)

References 14 publications

(21 reference statements)

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“…Unfortunately, subgroups with different foci were very small and statistical analyses unfeasible. There are previous studies which failed to see such an association in the more benign forms of SLFE [46,47], whereas a relationship between focus localization and specific cog-nitive impairments related to the brain regions affected is described repeatedly for the more severe forms [48][49][50][51]. Additionally, it has also been shown that children with epilepsy more often show atypically located language areas [45,52,53], indicating a compensational mechanism.…”

Section: Discussionmentioning

confidence: 96%

Sleep-dependent memory consolidation in children with self-limited focal epilepsies

Storz

Wilhelm

Critelli

et al. 2020

Epilepsy & Behavior

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ObjectiveChildren with self-limited focal epilepsies of childhood (SLFE) are known to show impaired memory functions, particularly in the verbal domain. Interictal epileptiform discharges (IED) in these epilepsies are more pronounced in nonrapid eye movement (NREM) sleep. Nonrapid eye movement sleep is crucial for consolidation of newly-encoded memories. Therefore, we hypothesize that sleep-dependent memory consolidation is altered in relation to IED in children with SLFE. Methods: We conducted a prospective case-control study. We applied a verbal (word pair) and a visuospatial (two-dimensional [2D] object location) learning task, both previously shown to benefit from sleep in terms of memory consolidation. Learning took place in the evening, and retrieval was tested in the morning after a night of sleep. Electroencephalogram (EEG) was recorded across night. After sleep-stage scoring, the spike-wave index (SWI) was assessed at the beginning and the end of sleep. Fourteen patients with SLFE (age: 5.5 to 11.6 years) were compared with 15 healthy controls (age: 6.8 to 9.1 years) examined in a previous study. Results: In contrast to healthy controls (mean: +12.9% recalled word pairs, p = .003, standard deviation (SD) = 12.4%), patients did not show overnight performance gains in the verbal memory task (mean: +6.4% recalled word pairs, p > .05, SD = 17.3) Neither patients nor controls showed significant overnight changes in visuospatial task performance. Spike-wave index was negatively correlated with recall performance in the verbal but not in the visuospatial task. Significance: We found evidence for impaired overnight improvement of performance in children with SLFE in a verbal learning task, with high SWI rates predicting low recall performance. We speculate that spike-waves hamper long-term memory consolidation by interfering with NREM sleep.

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