Early neuropsychological detection and the characteristics of Parkinson's disease associated with mild dementia

Song, In‐Uk; Kim, Joong‐Seok; Jeong, Du-Shin; Song, Hyunjoo; Lee, Kwang Soo

doi:10.1016/j.parkreldis.2008.01.007

Cited by 25 publications

(33 citation statements)

References 16 publications

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“…Patterns of responding (impaired organizational strategies and positive response bias) again suggest that these deficits are primarily related to frontal-executive dysfunction rather than memory loss mediated by the temporal lobes [47, 49, 52]. However, PD has also been associated with temporal and parietal hypoperfusion and atrophy [53–59], and some PDD patients also have neuropathologic changes consistent with AD [31, 60, 61]. As a result, some individuals with PD may present with AD-like memory impairments that are independent of executive dysfunction [48].…”

Section: Level Imentioning

confidence: 99%

“…Visuospatial dysfunction, which may be among the first cognitive changes noticed in PD [59, 77], is predictive of both cognitive decline and eventual dementia [78, 79]. The neuroanatomic substrate of defective visuospatial processing in PD is not well understood, but is hypothesized to result from asymmetric dopamine loss in the right basal ganglia [80], deficits in the dorsolateral prefrontal pathways with resulting structural and functional changes in the parietal lobes [81, 82], disruptions in the fronto-striatal loop [83], or other neuropathologic changes in the temporal, parietal, and/or occipital lobes [84].…”

Section: Level Imentioning

confidence: 99%

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Neuropsychologic assessment in collaborative Parkinson's disease research: A proposal from the National Institute of Neurological Disorders and Stroke Morris K. Udall Centers of Excellence for Parkinson's Disease Research at the University of Pennsylvania and the University of Washington

Watson

Cholerton

Gross

et al. 2012

Alzheimer's & Dementia

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Cognitive impairment (CI) and behavioral disturbances can be the earliest symptoms of Parkinson’s disease (PD), ultimately afflict the vast majority of PD patients, and increase caregiver burden. Our two Morris K. Udall Centers of Excellence for Parkinson’s Disease Research were supported by the National Institute of Neurological Disorders and Stroke (NINDS) to recommend a comprehensive yet practical approach to cognitive and behavioral assessment to fuel collaborative research. We recommend a step-wise approach with two levels of standardized evaluation to establish a common battery, as well as an alternative testing recommendation for severely impaired subjects, and review supplemental tests that may be useful in specific research settings. Our flexible approach may be applied to studies with varying emphasis on cognition and behavior, does not place undue burden on participants or resources, and has a high degree of compatibility with existing test batteries to promote collaboration.

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Section: Level Imentioning

confidence: 99%

Section: Level Imentioning

confidence: 99%

Neuropsychologic assessment in collaborative Parkinson's disease research: A proposal from the National Institute of Neurological Disorders and Stroke Morris K. Udall Centers of Excellence for Parkinson's Disease Research at the University of Pennsylvania and the University of Washington

Watson

Cholerton

Gross

et al. 2012

Alzheimer's & Dementia

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“…26 Cognitive issues, including attention, executive function, visual-spatial impairments and memory, and dementia, are more frequent in patients with PD than in age-matched controls. 16,17 Cognitive impairments correlate with gait and postural function. 18 Depressive symptoms may be found in as many as 40% of PD patients and may also impact motor functioning.…”

Section: Discharge Needs In Parkinson Diseasementioning

confidence: 99%

Do Co-Morbidities and Cognition Impact Functional Change and Discharge Needs in Parkinson Disease?

Marciniak

Choo²,

Toledo

et al. 2011

American Journal of Physical Medicine &Amp; Rehabilitation

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“…In PD, MCI may present with executive dysfunction [7] and visual-spatial deficits [8]. MCI exists as a prodromal stage for PDD.…”

Section: Introductionmentioning

confidence: 99%

Development of Clinical Dementia Rating Scale Cut‐off Scores for Patients With Parkinson's Disease

Wyman‐Chick

Scott

2015

Movement Disord Clin Pract

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Background The purpose of this study was to explore validity of the Clinical Dementia Rating Scale in measuring cognitive impairment among individuals with Parkinson's disease. The scale was created for use in patients with Alzheimer's disease and, to date, there have been no published studies examining if this tool is appropriate for patients with Parkinson's disease. Methods The data were obtained from the National Alzheimer's Coordinating Center database and included 490 subjects diagnosed with Parkinson's disease, further categorized as having Parkinson's disease dementia (n= 151), mild cognitive impairment (n= 186), or normal cognition (n = 153) by a treating physician. Sensitivity, specificity, positive predictive value and negative predictive values were calculated for the Clinical Dementia Rating Scale Global Score as well as the Sum of Boxes Score using existing cutoff scores. Finally, new cutoff scores were calculated using sensitivity and specificity values derived using Receiver Operating Characteristic curves. Results Sensitivity and specificity of the published Global Score cutoff scores for patients with dementia were .34 and .10, respectively. The newly calculated cutoff scores for patients with dementia yielded a sensitivity of .79 and a specificity of .96. The area under the curve was 0.92 (95% CI = 0.90-0.95). Conclusion The CDR is a useful tool in identifying dementia in patients with Parkinson's disease when the cutoff scores are adjusted.

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Early neuropsychological detection and the characteristics of Parkinson's disease associated with mild dementia

Cited by 25 publications

References 16 publications

Neuropsychologic assessment in collaborative Parkinson's disease research: A proposal from the National Institute of Neurological Disorders and Stroke Morris K. Udall Centers of Excellence for Parkinson's Disease Research at the University of Pennsylvania and the University of Washington

Neuropsychologic assessment in collaborative Parkinson's disease research: A proposal from the National Institute of Neurological Disorders and Stroke Morris K. Udall Centers of Excellence for Parkinson's Disease Research at the University of Pennsylvania and the University of Washington

Do Co-Morbidities and Cognition Impact Functional Change and Discharge Needs in Parkinson Disease?

Development of Clinical Dementia Rating Scale Cut‐off Scores for Patients With Parkinson's Disease

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