Early Menarche in Japanese Down Syndrome

Takano, Toshiya; Takaki, Haruyoshi; Kawano, Hatsuko; Nonaka, Kazuhiro

doi:10.1542/peds.103.4.854

Cited by 9 publications

(9 citation statements)

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“…The average age of menarche among Danish girls with Down syndrome was similar to that of controls, ( 63 ) whereas Japanese girls with Down syndrome had earlier menarche compared with the general population. ( 64 ) Concerning the pubertal development in male patients with Down syndrome, Arnell et al ( 65 ) demonstrated primary gonadal insufficiency in this patient population. The levels of other hormones, such as FSH, luteinizing hormone and testosterone, however, were similar between male adolescents with and without Down syndrome.…”

Section: Discussionmentioning

confidence: 64%

Evaluation of uric acid levels, thyroid function, and anthropometric parameters in Japanese children with Down syndrome

Niegawa

Takitani

Takaya

et al. 2017

J. Clin. Biochem. Nutr.

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Down syndrome, caused by trisomy 21, is characterized by congenital abnormalities as well as mental retardation. From the neonatal stage through adolescence, patients with Down syndrome often have several complications. Thus, it is important to attain knowledge of the prevalence of these comorbidities in children with Down syndrome. We, therefore, evaluated the biochemical data, thyroid function, and anthropometric parameters, and analyzed the association among them in Japanese children and early adolescents with Down syndrome. There was no difference in the prevalence of obesity and overweight between boys and girls. The level of uric acid was higher in boys than in girls. Moreover, the prevalence of hyperuricemia was also higher in boys than in girls (approximately 32% and 10%, respectively). The prevalence of subclinical hypothyroidism in children with Down syndrome was approximately 20%, with no significant sex differences. The levels of uric acid and dehydroepiandrosterone-sulfate were positively associated with age, while the levels of thyroid-stimulating hormone and free thyroxine had a negative association with age. Overall, children with Down syndrome, exhibit a higher incidence of hyperuricemia. Therefore, uric acid levels, as well as thyroid function, from childhood to early adulthood should be monitored in this patient cohort.

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Section: Discussionmentioning

confidence: 64%

Evaluation of uric acid levels, thyroid function, and anthropometric parameters in Japanese children with Down syndrome

Niegawa

Takitani

Takaya

et al. 2017

J. Clin. Biochem. Nutr.

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“…When the menarcheal age of our female patients with DS was compared with the findings of the literature, the age of menarche in girls with DS was found to be younger compared to studies with similar numbers of subjects (5, 6). However, no difference was found from the studies conducted with more subjects (7,15). The four comparable studies are those that were published 2-3 decades ago.…”

Section: Discussionmentioning

confidence: 90%

Is there a secular trend regarding puberty in children with down syndrome?

Erdogan

Güven²

2022

Front. Endocrinol.

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IntroductionThere are very few studies on the age of onset and end of puberty in children with Down syndrome (DS). Also, data regarding the course of puberty in these children compared to their healthy peers is limited. Moreover, there is limited information regarding the effects of factors such as obesity and hypothyroidism on the puberty process in children with DS. Our aim in our study is to determine whether the pubertal development of children with DS differs from their healthy peers and from previous studies conducted with DS children.MethodsThe medical records of DS children were examined retrospectively. The anthropometric measurements and the age of onset of pubertal stages, and menarche were recorded. The patients’ age at puberty onset, the puberty processes, and age at menarche were compared with their healthy peers and previously published data on children with DS.ResultsOf the 140 Down syndrome patients followed in our clinic, 51 of whom with puberty constituted the study group. The mean age of onset of puberty was 10.3 ± 1.0 years in our group (10.0 ± 0.8 years for girls, 10.6 ± 1.2 years for boys, respectively). Obesity occurred in 46% of pubertal girls with DS. The age of menarche in girls with DS was 11.8 ± 0.7 years. The menarche age of girls with DS was significantly different from healthy girls. In the DS boys, only the Tanner V stage ages were different from the healthy children. True- precocious-puberty was detected in three children.ConclusionAlthough breast development begins later in females with DS than in their healthy peers; menarche is detected earlier than in their peers and a tendency towards obesity in the whole population. While the age of pubertal onset was similar to healthy children in male patients, our findings suggest that their puberty duration is longer.

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“…Since children with Down's syndrome enter the pubertal growth spurt earlier, it is very likely that they have early puberty. There are reports showing that girls with Down's syndrome have earlier menarche than in the general population (19,20). Unfortunately, the appearance of secondary sexual characteristics could not be examined in this study, since hospital visits at pubertal age occurred only once a year and the accurate age of their appearance could not be determined.…”

Section: Discussionmentioning

confidence: 92%