Early Maternal Serum β-human Chorionic Gonadotropin Measurements After ICSI in the Prediction of Long-term Pregnancy Outcomes: A Retrospective Cohort Analysis

Abstract

BackgroundInitial low maternal serum β-human chorionic gonadotropin (β-hCG) is a good predictor of early pregnancy demise. Our objective was to determine its predictive value in determining the long-term outcome in ICSI pregnancies.MethodsA retrospective cohort study was designed at the Saudi Center for Assisted Reproduction. Two hundred and sixty-one women with ICSI pregnancies were followed up from initial β-hCG level determination till the end of pregnancy. Accuracy of early β-hCG in predicting the occurrence of a live-birth, ongoing pregnancy, late miscarriage, ectopic pregnancy and early miscarriage following ICSI was measured.Resultsβ-hCG levels were significantly different in pregnancies that reached the stage of an ongoing pregnancy and live-birth as compared to early pregnancy loss. The ROC curves demonstrated a high sensitivity for identifying patients with ectopic pregnancies and early miscarriage (100% and 93.33% respectively). The remaining results ranged from a sensitivity of 69% to 79% and specificity of 62% to 75%.ConclusionsIn ICSI pregnancies, a single early β-hCG may help to identify pregnancies that will reach full-term and delivery.KeywordsICSI; Human chorionic gonadotropin; Outcome; Pregnancy

Prognostic value of a serum β-hCG cut off, 12 days after fresh embryo transfer, on predicting live birth among Ugandan women

“…In addition, the false positive rate, indicated similar suboptimal performance, ranged between a lower 23.4 [43] and a comparable 38.8% [44]. But for the most part, our population cut off was 2-4 fold higher than that reported by others such as 50mIU/ml [46], 76mIU/ml [33], 78mIU/ml [47], 85mIU/ml [45], 131 mIU/ml [48]; 104.5mIU/ml [27], 145mIU/ml [29], 199 mIU/ml [49], 222.86 mIU/ml [50], 253 mIU/ml [49], and 315.65mIU/ml [32].The associated false positive rates indicated variable predictive performance and ranged between 10% [47] and 50% [49].…”

“…Several authors [17,[21][22][23][24][25][26][27] built on this work, demonstrating the ability of serial serum β-hCG levels to predict clinical and ongoing pregnancies after IVF. Furthermore, others [16,[28][29][30][31][32][33][34][35] have extensively evaluated the ability of a single serum β-hCG level, taken 12-16 days after embryo transfer, to predict pregnancy outcomes after IVF.…”

Initial maternal serum human chorionic gonadotropin levels in pregnancies achieved after assisted reproductive technology are higher after preimplantation genetic screening and after frozen embryo transfer: a retrospective cohort

“…Initial hCG values have been shown to predict pregnancy viability-increased risk of miscarriage and ectopic pregnancy with lower initial hCG values and live birth prediction with higher initial hCG levels [30]. Similar findings have been corroborated after IVF cycles [32]. Recently, higher initial hCG values after fresh IVF were predictive of ongoing pregnancy [33][34][35].…”

Uso de letrozol no tratamento da gestação ectópica: relato de caso

“…Sabe-se também que em uma gestação normal, o nível de β-hCG pode dobrar em poucos dias no primeiro trimestre (ESKANDAR et al, 2011;HADDADEN et al, 2021), de forma semelhante, no presente caso clínico, a paciente apresentou aumento da concentração sérica em 58,44% em 3 dias, sendo notado a redução da concentração desse hormônio após a intervenção farmacológica, chegando a níveis pré-gravídicos no dia 10/06/22. Desse modo, é possível perceber a eficácia do tratamento, comprovada posteriormente pela USTV bem como pela Histerossalpingografia.…”