Early maternal deprivation in rats induces gender‐dependent effects on developing hippocampal and cerebellar cells

Llorente, Ricardo; Gallardo, Meritxell López; Berzal, Alvaro Llorente; Prada, Cármen; Garcia-Segura, Luis Miguel; Viveros, María-Paz

doi:10.1016/j.ijdevneu.2009.01.002

Cited by 95 publications

(77 citation statements)

References 71 publications

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“…One explanation could be the well-known age-related reduction in neurogenesis that -due to the progressive slowing down of DG turnover at older ages (Heine et al, 2004) -may eventually normalize initial differences induced by ELS in DG cell number or density. The fact that MD also increases cell death in the infant rat hippocampus in a sex-dependent manner supports the concept of (transient) changes in turnover rate after MD, that may normalize at later ages (Zhang et al, 2002;Llorente et al, 2009). Alternatively, differences between the experimental design of the various studies may have contributed, as separate groups were used before for structural hippocampal analysis and for behavioral analysis (Oomen et al, 2009(Oomen et al, , 2011, whereas the present anatomical data were obtained from animals that had been used for behavioral analysis before.…”

Section: Discussionsupporting

confidence: 61%

Effects of early-life stress on cognitive function and hippocampal structure in female rodents

et al. 2017

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Effects of early-life stress on cognitive function and hippocampal structure in female rodents Loi, M.; Mossink, J.C.L.; Meerhoff, G.F.; den Blaauwen, J.L.; Lucassen, P.J.; Joëls, M. General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Abstract-We tested the effect of early-life stress (ELS) -24 h maternal deprivation (MD) at postnatal day (PND) 3 -on cognitive performance and hippocampal structure in 12-17-week-old female rats. Behavioral performance was examined in: the Elevated Plus Maze, as an index for general anxiety; the rodent Iowa gambling test, probing reward-based decision making; and the object recognition and object-in-location task, to assess non-stressful contextual memory performance. We further determined hippocampal dentate gyrus (DG) volume and cell density as well as adult proliferation and neurogenesis rates. Half of the rats was treated with the glucocorticoid receptor antagonist mifepristone during a critical pre-pubertal developmental window , in an attempt to ameliorate the potentially adverse behavioral consequences of ELS. Neither MD nor treatment with the glucocorticoid antagonist affected behavioral performance of the females in any of the tasks. Also, DG structure, proliferation and neurogenesis were not different between the groups. Lack of structural differences and a behavioral phenotype in non-stressful hippocampus dependent learning tasks fits with the lack of phenotype generally reported after ELS in female but less so in male rodents. As evident from an extensive literature review, female and male animals appear to respond more similarly to early-life adversity when tested in anxiety-related tasks. This agrees with recent findings in humans suggesting that females may be relatively resilient to the structural/hippocampal effects of childhood maltreatment, but not to the anxiety and mood-related psychopathology for which childhood maltreatment is considered a risk factor.

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Section: Discussionsupporting

confidence: 61%

Effects of early-life stress on cognitive function and hippocampal structure in female rodents

et al. 2017

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“…Previous reports have described increased astrocyte density in the hippocampus and cerebellum, with a slight increase in the PFC, of neonatal MD male rats 34,36,41 Table 1). In addition, female rats (both control and MD) weighed significantly less than their male counterparts from PND28 onwards (Two-way ANOVA effect of Sex: F (1,75) = 343.70 P < 0.001).…”

Section: Discussionmentioning

confidence: 71%

“…The maternal deprivation (MD) protocol took place on PND9 as previously described 32,34 . In brief, on PND9, half of the litters were submitted to 24 hours of MD, i.e.…”

Section: Maternal Deprivationmentioning

confidence: 99%

“…Stressful rearing conditions are associated with a number of neuroimmune alterations such as downregulated expression of microglial markers, cytokines (IL-10, IL-1β), chemokines (CCL7) and receptors (IL-5 receptor-alpha, CCR4) in the brain 13 . In addition, early-life stress reportedly reduces the expression of astrocytic markers (S100β, GFAP) in the anterior cingulate and precentral medial cortices 44 and increases astrocyte density in the hippocampus and cerebellum 34,36,41 . However, it is unknown if alterations in pro-inflammatory cytokines occur in key brain regions involved in emotional and nociceptive processing in the MD model.…”

Section: Introductionmentioning

confidence: 99%

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Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury

Burke

Llorente

Marco

et al. 2013

The Journal of Pain

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Maternal deprivation is associated with sex dependant alterations in nociceptive behaviour and neuroinflammatory mediators in the rat following peripheral nerve injury. AbstractEarly-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and following peripheral nerve injury (L5-L6 spinal nerve ligation (SNL)). As neuroimmune signalling plays an important role in pain and affective disorders, associated alterations in glial and cytokine expression were assessed in key brain regions associated with emotional and nociceptive responding, the hippocampus and prefrontal cortex (PFC). MD female, but not male, rats exhibited thermal hypoalgesia and mechanical allodynia when compared to control (non-MD) counterparts. SNL resulted in mechanical and cold allodynia in MD and control rats of both sexes. However, MD females exhibited enhanced SNL-induced allodynic responding when compared to non-MD counterparts. IL-6 expression was reduced in the PFC of MD-SNL males when compared with non-SNL counterparts. GFAP and IL-1β expression in the hippocampus of MD-SNL males was increased compared with non-MD controls. MD-SNL females exhibited reduced TNFα in the PFC with a concomitant increase in IL-6 and TNFα expression in the hippocampus, compared with either MD or SNL alone. In conclusion, MD female, but not male, rats exhibit enhanced nociceptive responding following peripheral nerve injury, effects which may relate to the distinct neuroinflammatory profile observed in female versus male rats.Perspective: This study demonstrates that females rats exposed to early-life stress exhibit enhanced neuropathic pain responding, effects associated with alterations in neuroinflammatory mediators. Increased understanding of the interactions between early-life stress, gender and pain may lead to the identification o novel therapeutic targets for the treatment of chronic pain disorders.

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“…Yöntem farklılıklardan kaynaklanan davranışsal ve moleküler farklı sonuç elde edilmektedir. Fakat genel olarak literatürde, anne yoksunluğuna bağlı olumsuz davranışların görülme sıklığında artış gösterilmiştir 4,6 .…”

Section: Anne Yoksunluğunun Deneysel Modelleriunclassified

Deneysel Modellerde Anne Yoksunluğunun Beyin ve Davranışlar Üzerine Etkisi

Akıllıoğlu¹,

Karadepe²,

Binokay³

2014

Arşiv Kaynak Tarama Dergisi

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Adverse experiences in early developmental periods have significant effects on the adulthood behaviors. Maternal deprivation can be defined as prolonged loss of the care of the mother to the infant which may have intense and/or long continued even irreversible effects on the child's personality development. Maternal deprivation lead to structural, functional, neurochemical and behavioural alterations. The aim of this review is to examine the effects of maternal deprivation on the central nervous system and behavior in the light of current studies. Key words: Maternal deprivation, behaviour, central nervous system, neonatal. ÖZETErken gelişim döneminde yaşanan olumsuz deneyimler yetişkinlik dönemi davranışlarını etkilemektedir. Anne yoksunluğu, uzun süreli anne bakımından yoksun kalma sonucunda çocuğun kişilik gelişiminde geri dönüşümsüz ve şiddetli etkilerin olması şeklinde tanımlanmaktadır. Anne yoksunluğu, merkezi sinir sisteminde yapısal, hormonal, nörokimyasal ve davranışsal bir takım değişikliklere yol açmaktadır. Buyazıda, güncel çalışmalar ışığında, anne yoksunluğunun merkezi sinir sistemi ve davranışlar üzerindeki etkileri incelenmiştir. Anahtar kelimeler: Anne yoksunluğu, davranış, merkezi sinir sistemi, yenidoğan.

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Early maternal deprivation in rats induces gender‐dependent effects on developing hippocampal and cerebellar cells

Cited by 95 publications

References 71 publications

Effects of early-life stress on cognitive function and hippocampal structure in female rodents

Effects of early-life stress on cognitive function and hippocampal structure in female rodents

Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury

Deneysel Modellerde Anne Yoksunluğunun Beyin ve Davranışlar Üzerine Etkisi

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