“…Due to the high heterogeneity of patients and overall small sample sizes, however, it is difficult to summarize all the published literature regarding post‐transplant immune reconstitution. Previous studies usually did not conduct an independent validation of their major results and in addition were often limited by small population size (less than 200 patients) 1 , 3 , 6 , 8 , 9 , 10 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 or short duration of immune profiling (1 year or less). 3 , 4 , 6 , 7 , 8 , 9 , 11 , 12 , 14 , 15 , 17 , 19 , 21 , 22 , 23 , 25 Moreover, aside from some exceptions, 10 , 26 , 27 researchers often did not evaluate multiple immune variables holistically when assessing a patient's immune reconstitution; in other words, there has been no consensus on how to assign a score to a patient's multi‐time‐point and multivariate immune data.…”