Early Life Stress and Metabolic Plasticity of Brain Cells: Impact on Neurogenesis and Angiogenesis

Салмина, А. Б.; Gorina, Yana V.; Kоmleva, Yu. K.; Panina, Yulia; Malinovskaya, N. A.; Lopatina, Olga

doi:10.3390/biomedicines9091092

Cited by 14 publications

(6 citation statements)

References 249 publications

(232 reference statements)

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“…Cognitive functions depend not only on neurogenesis but also on adequate vascularization of the brain. The suppression of cerebral angiogenesis results in the impairment of L&M (Salmina et al ., 2021).…”

Section: Discussionmentioning

confidence: 99%

The effect of early and long-term propranolol therapy on learning and memory in mice

Orhan¹,

Tanyeri

Büyükokuroğlu

et al. 2023

Behavioural Pharmacology

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Propranolol is the treatment of choice for infantile hemangioma. We investigated the effects of long-term propranolol use in early infancy on learning and memory later in life in mice. At three weeks of age, mice were randomly divided into six experimental groups. Groups 1 and 2 (controls) received only saline for 21 days. Groups 3 and 4 received propranolol (2.5 mg/kg) for 21 days. Groups 5 and 6 received propranolol (5 mg/kg) for 21 days. Groups 1, 3 and 5 were tested at the end of 21 days of treatment (week 6). However, groups 2, 4 and 6 received a 2-week break and then (week 8) exposed to tests. In the Morris water maze test, propranolol (2.5 and 5 mg/kg) dose-dependently increased the time spent in the target quadrant in mice at weeks 6 and 8. However, propranolol did not affect the swimming speed in both time periods. There were no significant effects of propranolol on the number of errors evaluated during the radial arm maze tests. In conclusion, long-term use of propranolol in early infancy did not disrupt the learning and memory of mice.

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Section: Discussionmentioning

confidence: 99%

The effect of early and long-term propranolol therapy on learning and memory in mice

Orhan¹,

Tanyeri

Büyükokuroğlu

et al. 2023

Behavioural Pharmacology

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“…Власова «Анализ основных мировых трендов в объективизации протоколов поведенческого тестирования лабораторных животных с патологией головного мозга» за хвост, в частности, по результатам анализа исследовательского интереса [15,19], причём такие преимущества сохраняются и после дополнительных инвазивных процедур (инъекции, анестезия) [20]. Любой другой вид стрессового фактора значимо меняет поведенческий ответ экспериментальных животных, что очевидно и в классических моделях, например, стресс раннего периода жизни, приводящий к развитию депрессии или повышению риска возникновения нейродегенерации в отдалённые периоды онтогенеза [29,37], и при анализе поведенческого фенотипа животных, подвергающихся действию стресса социальной изоляции или иммобилизационном стрессе в более позднем периоде развития [27].…”

Section: объективные и субъективные факторы определяющие качество вып...unclassified

Analysis of Main World Trends in Objectivization of Protocols for Behavioral Testing of Laboratory Animals with Brain Pathology

et al. 2023

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Behavioral phenotyping of rodents using neurodegeneration models has received much research attention over the past three decades. However, some difficulties still exist in understanding the variability of behavior caused by genetic, environmental, and biological factors, human intervention and poorly standardized experimental protocols, which can negatively affect the interpretation of the results obtained. In this article, we discuss factors that have a negative impact on the performance of behavioral testing of laboratory animals, modern approaches to overcome them, as well as new technologies, such as visualization of neuronal activity using ion-dependent fluorescent indicators (optogenetics), which expand the boundaries of the study of neuronal networks responsible for behavior by evaluating neuronal function at both the cellular and population levels. Ultimately, this will increase the reliability of the results obtained and provide an opportunity to take a fresh look at the ethological paradigms of a particular transgenic mouse model.

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“…Neoangiogenesis, in addition to neurogenesis, is critically important for effective learning and memory consolidation [ 134 ]. It is most probably determined by high metabolic demands in the active neurogenic niches and other brain regions [ 135 ]. Obviously, the cessation of such a request should lead to a gradual regression of the microvascular density.…”

Section: Regulation and Outcomes Of Vascular Regression And Pruning I...mentioning

confidence: 99%

Physiological and Pathological Remodeling of Cerebral Microvessels

Tregub

Averchuk

Baranich

et al. 2022

IJMS

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There is growing evidence that the remodeling of cerebral microvessels plays an important role in plastic changes in the brain associated with development, experience, learning, and memory consolidation. At the same time, abnormal neoangiogenesis, and deregulated regulation of microvascular regression, or pruning, could contribute to the pathogenesis of neurodevelopmental diseases, stroke, and neurodegeneration. Aberrant remodeling of microvesselsis associated with blood–brain barrier breakdown, development of neuroinflammation, inadequate microcirculation in active brain regions, and leads to the dysfunction of the neurovascular unit and progressive neurological deficits. In this review, we summarize current data on the mechanisms of blood vessel regression and pruning in brain plasticity and in Alzheimer’s-type neurodegeneration. We discuss some novel approaches to modulating cerebral remodeling and preventing degeneration-coupled aberrant microvascular activity in chronic neurodegeneration.

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Early Life Stress and Metabolic Plasticity of Brain Cells: Impact on Neurogenesis and Angiogenesis

Cited by 14 publications

References 249 publications

The effect of early and long-term propranolol therapy on learning and memory in mice

The effect of early and long-term propranolol therapy on learning and memory in mice

Analysis of Main World Trends in Objectivization of Protocols for Behavioral Testing of Laboratory Animals with Brain Pathology

Physiological and Pathological Remodeling of Cerebral Microvessels

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