Early life experience alters behavior during social defeat: Focus on serotonergic systems

Gardner, K. H.; Thrivikraman, K. V.; Lightman, Stafford L.; Plotsky, PM; Lowry, CA

doi:10.1016/j.neuroscience.2005.07.042

Cited by 156 publications

(140 citation statements)

References 40 publications

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“…In line with these results and HPA axis studies, it has been demonstrated that the serotonin (5-hydroxytryptamine or 5-HT) system is influenced by animal maternal deprivation (Gardner, Thrivikraman, Lightman, Plotsky, & Lowry, 2005). Importantly, the HPA axis is also under tonic 5-HT (inhibitory) neurotransmission (see previous paragraph on the feedback mechanism).…”

Section: Neurobiological Underpinnings Of Impaired Attentional Controsupporting

confidence: 69%

Understanding vulnerability for depression from a cognitive neuroscience perspective: A reappraisal of attentional factors and a new conceptual framework

Raedt

Koster

2010

Cognitive, Affective, & Behavioral Neuroscience

493

379

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Section: Neurobiological Underpinnings Of Impaired Attentional Controsupporting

confidence: 69%

Understanding vulnerability for depression from a cognitive neuroscience perspective: A reappraisal of attentional factors and a new conceptual framework

Raedt

Koster

2010

Cognitive, Affective, & Behavioral Neuroscience

493

379

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“…24 Some overall conclusions that can be drawn from the present neurochemistry data set are that tissue concentrations of 5-HT and 5-HIAA are generally elevated in Ucn1/Ucn2 dKO mice within an anxiety-related neural circuit that receives projections from the caudal and dorsal parts of the DRN, regions of the DRN that are targeted by anxiety-related stimuli, anxiogenic drugs and anxiety-related neuropeptides, such as Ucn1 and Ucn2. 20,22,48,67,82,90,95,96 These effects are largely driven by effects of genotype on both 5-HT and 5-HIAA tissue concentrations within females, with a smaller effect of genotype in males. Analyses of additional 5-HT projection regions will reveal how widespread the effect of genotype is on increased tissue concentrations of 5-HT and 5-HIAA.…”

Section: Discussionmentioning

confidence: 99%

Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits

et al. 2009

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The urocortin (Ucn) family of neuropeptides is suggested to be involved in homeostatic coping mechanisms of the central stress response through the activation of corticotropin-releasing factor receptor type 2 (CRFR2). The neuropeptides, Ucn1 and Ucn2, serve as endogenous ligands for the CRFR2, which is highly expressed by the dorsal raphe serotonergic neurons and is suggested to be involved in regulating major component of the central stress response. Here, we describe genetically modified mice in which both Ucn1 and Ucn2 are developmentally deleted. The double knockout mice showed a robust anxiolytic phenotype and altered hypothalamic-pituitary-adrenal axis activity compared with wild-type mice. The significant reduction in anxiety-like behavior observed in these mice was further enhanced after exposure to acute stress, and was correlated with the levels of serotonin and 5-hydroxyindoleacetic acid measured in brain regions associated with anxiety circuits. Thus, we propose that the Ucn/ CRFR2 serotonergic system has an important role in regulating homeostatic equilibrium under challenge conditions.

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“…In response to FG-7142, these animals also showed activation of left but not right mPFC neurons. This deficit in right mPFC function with MS could result in impaired adaptive coping responses to stressors which may account, at least in part, for the enhanced vulnerability to stress observed in these animals (Caldji et al, 2000;Huot et al, 2001;Francis et al, 2002;Ladd et al, 2004;Plotsky et al, 2005;Gardner et al, 2005). Furthermore, the finding of selective activation of right mPFC neurons by FG-7142 with H may model the enhanced resilience to stress seen in these animals (Meaney et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Early life programming of hemispheric lateralization and synchronization in the adult medial prefrontal cortex

et al. 2008

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Abstract-Neonatal maternal separation (MS) in the rat increases the vulnerability to stressors later in life. In contrast, brief handling (H) in early life confers resilience to stressors in adulthood. Early life programming of stress reactivity may involve the medial prefrontal cortex (mPFC), a region which modulates various stress responses. Moreover, hemispheric specialization in mPFC may mediate adaptive coping responses to stress. In the present study, neuronal activity was examined simultaneously in left and right mPFC in adult rats previously subjected to MS, H or animal facility rearing (AFR). In vivo electrophysiology, under isoflurane anesthesia, was used to conduct acute recordings of unit and local field potential (LFP) activity in response to systemic administration of N-methyl-␤-carboline-3-carboxamide (FG-7142), a benzodiazepine receptor partial inverse agonist which mimics various stress responses. MS decreased basal unit activity selectively in right mPFC. Basal LFP activity was reduced with MS in left and right mPFC, compared to AFR and H, respectively. Hemispheric synchronization of basal LFP activity was also attenuated by MS at lower frequencies. FG-7142 elicited lateralized effects on mPFC activity with different early rearing conditions. Activity in left mPFC was greater with AFR and MS (AFR>MS), whereas activity was predominantly greater with H in right mPFC. Finally, compared to AFR, MS reduced and H enhanced hemispheric synchronization of LFP activity with FG-7142 treatment in a dose-dependent manner.These results indicate that functionally-relevant alterations in mPFC GABA transmission are programmed by the early rearing environment in a hemisphere-dependent manner. These findings may model the hemispheric specialization of mPFC function thought to mediate adaptive coping responses to stressors. They also suggest the possibility that early environmental programming of hemispheric functional coupling in mPFC is involved in conferring vulnerability or resilience to stressors later in life.

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Early life experience alters behavior during social defeat: Focus on serotonergic systems

Cited by 156 publications

References 40 publications

Understanding vulnerability for depression from a cognitive neuroscience perspective: A reappraisal of attentional factors and a new conceptual framework

Understanding vulnerability for depression from a cognitive neuroscience perspective: A reappraisal of attentional factors and a new conceptual framework

Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits

Early life programming of hemispheric lateralization and synchronization in the adult medial prefrontal cortex

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