Early life blood lead levels and asthma diagnosis at age 4–6 years

Abstract

The USA has a high burden of childhood asthma. Previous studies have observed associations between higher blood lead levels and greater hypersensitivity in children. The objective of the present study was to estimate the association between blood lead concentrations during early childhood and an asthma diagnosis between 48 and 72 months of age amongst a cohort with well-characterized blood lead concentrations. Blood lead concentrations were measured at 6, 12, 18, 24, 36, and 48 months of age in 222 children. The presence of an asthma diagnosis between 48 and 72 months was assessed using a questionnaire which asked parents or guardians whether they had been told by a physician, in the past 12 months, that their child had asthma. Crude and adjusted risk ratios (RR) of an asthma diagnosis were estimated for several parameterizations of blood lead exposure including lifetime average (6 to 48 months) and infancy average (6 to 24 months) concentrations. After adjustment for child sex, birthweight, daycare attendance, maternal race, education, parity, breastfeeding, income, and household smoking, age-specific or composite measures of blood lead were not associated with asthma diagnosis by 72 months of age in this cohort.

A case-control study on asthma and obese patients: Influence of lifestyle patterns, serum trace elements, heavy metals, and total antioxidants

“…The intricate relationships between these trace elements and blood pressure require more investigation to be completely understood. The incidence and development of cerebral blood vessels in the heart have been linked to an imbalance of metals including cobalt, zinc, copper, and magnesium, according to some studies [ 22 ].…”

Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice

“…Environmental pollutions due to industrial and economic activities have posed various health risks [1][2][3]. Per-and polyfluoroalkyl substances (PFASs) have been used since approximately the 1940s as water and oil repellents, aqueous film-forming foam as a fire extinguisher, and surfactants [4].…”

Association between Exposure to Selected Heavy Metals and Blood Eosinophil Counts in Asthmatic Adults: Results from NHANES 2011–2018

“…Previous studies observed that asthma induced by heavy metals was triggered by the immune system, indicating that heavy metals have great inflammatory potential and immunomodulatory effects on individuals [ 27 , 28 ]. Many studies have reported the association between heavy metals (Pb, Cd, Hg and Mn) and asthma [ 24 , 29 , 30 , 31 , 32 , 33 ].…”