Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice
Kazuyoshi Furukawa,
Kahori Okamoto-Matsuda,
Kouji H. Harada
et al.
Abstract:Background
Perfluorooctanoic acid (PFOA) is one of the major per- and polyfluoroalkyl substances. The role of ATP-binding cassette (ABC) transporters in PFOA toxicokinetics is unknown.
Methods
In this study, two ABC transporters, ABCB1 and ABCB4, were examined in mice with single intravenous PFOA administration (3.13 µmol/kg). To identify candidate renal PFOA transporters, we used a microarray approach to evaluate changes in gene expression of various kidney transporter… Show more
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