Early life antibiotic use and the risk of asthma and asthma exacerbations in children

Ahmadizar, Fariba; Vijverberg, Susanne J. H.; Arets, Hubertus G.M.; Boer, Anthonius de; Turner, Steven; Devereux, Graham; Arabkhazaeli, Ali; Soares, Patrícia; Mukhopadhyay, Somnath; Garssen, Johan; Palmer, Colin N.A.; Jongste, Johan C. de; Jaddoe, Vincent W. V.; Duijts, Liesbeth; Meel, Evelien R. van; Kraneveld, Aletta D.; Zee, Anke‐Hilse Maitland‐van der

doi:10.1111/pai.12725

Cited by 80 publications

(49 citation statements)

References 23 publications

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“…The excessive use of antibiotics contributes to dysbiosis which should be concerning, particularly in regards to infants, as it has been shown that the use of antibiotics in infancy induces dysbiosis later in life . In fact, antibiotic use in the first 3 years of life has been directly linked to an increased risk of developing asthma which is discussed later in the review . Breast milk is a also a key factor that influences the microbiome diversity in infancy …”

Section: Gut Microbiota and Dysbiosismentioning

confidence: 99%

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The role of gut microbiota in atopic asthma and allergy, implications in the understanding of disease pathogenesis

et al. 2020

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Asthma is a clinical syndrome characterized by chronic airway inflammation. There is mounting evidence on the role of microbiota in the development of asthma. This review focuses on the role of microbiota in maintaining the integrity of the epithelia and their role in regulating the immune response. The review compiles data from multiple studies on the role of microbiota in the innate immune response and the development and differentiation of CD4+ T cells, a major component of the adaptive arm of the immune response. As a result of dysbiosis, invariant natural killer T cells may induce T helper 2 cell differentiation and immunoglobulin E isotype switching through the release of interleukin‐4 and interleukin‐13. Furthermore, degradation of immunoglobulin A antibodies, increased circulating mast cells and basophils, and inflammation are among other mechanisms by which dysbiosis can induce or exacerbate asthma. After explaining the underlying mechanisms, the review derives conclusions from studies that investigate dysbiosis in infancy and the development of asthma later in life. The review also includes studies that investigate asthmatic mothers and the development of asthma in children and the role of dysbiosis in that regard. Finally, the review explains the statistical relationship between eczema and asthma through multiple studies that investigate the role of dysbiosis in both atopic states. This review provides insight into the role of dysbiosis in asthma, and an understanding that is required to establish clinical trials which aim to modulate the gut microbiota as a means of preventing and treating asthma.

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Section: Gut Microbiota and Dysbiosismentioning

confidence: 99%

“…23 In fact, antibiotic use in the first 3 years of life has been directly linked to an increased risk of developing asthma which is discussed later in the review. 24 Breast milk is a also a key factor that influences the microbiome diversity in infancy. 4…”

Section: Gut Microbiota and Dysbiosismentioning

confidence: 99%

The role of gut microbiota in atopic asthma and allergy, implications in the understanding of disease pathogenesis

et al. 2020

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“…Despite that there was inconsistency about the most important time period (whether the first 3 months or the first year of life) to shape asthma risk later in life, it is apparent that gut or airway microbiota disturbances at an early age, especially the first year of life, are risk factors for asthma development. This bacterial dysbiosis may explain why early life antibiotic exposure may increase risk of later asthma development …”

Section: Latest Insights Into Microbial Dysbiosis and Asthma Phenotypmentioning

confidence: 99%

The crosstalk between microbiome and asthma: Exploring associations and challenges

Abdel‐Aziz

Vijverberg

Neerincx

et al. 2019

Clin Experimental Allergy

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With the advancement of high‐throughput DNA/RNA sequencing and computational analysis techniques, commensal bacteria are now considered almost as important as pathological ones. Understanding the interaction between these bacterial microbiota, host and asthma is crucial to reveal their role in asthma pathophysiology. Several airway and/or gut microbiome studies have shown associations between certain bacterial taxa and asthma. However, challenges remain before gained knowledge from these studies can be implemented into clinical practice, such as inconsistency between studies in choosing sampling compartments and/or sequencing approaches, variability of results in asthma studies, and not taking into account medication intake and diet composition especially when investigating gut microbiome. Overcoming those challenges will help to better understand the complex asthma disease process. The therapeutic potential of using pro‐ and prebiotics to prevent or reduce risk of asthma exacerbations requires further investigation. This review will focus on methodological issues regarding setting up a microbiome study, recent developments in asthma bacterial microbiome studies, challenges and future therapeutic potential.

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“…Antibiotic use in early childhood could influence asthma risk, via effects on the developing microbiome. Ahmadizar et al looked at data from several large birth cohort studies to see if antibiotic use in the first three years of life is associated with development or exacerbation of asthma. In the Generation R and SEATON cohorts, antibiotic use was associated with increased risk of asthma, with an OR of 2.18.…”

Section: Introductionmentioning

confidence: 99%

Pediatric Pulmonology year in review 2017: Part 3

Ren

Muston

Yılmaz

et al. 2018

Pediatric Pulmonology

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Our journal covers a broad range of research and scholarly topics related to children's respiratory disorders. For updated perspectives on the rapidly expanding knowledge in our field, we will summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. The current review covers articles on neonatal lung disease, pulmonary physiology, and respiratory infection.Word count: 71 3

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Early life antibiotic use and the risk of asthma and asthma exacerbations in children

Abstract: Children treated with antibiotic in the first 3 years of life are more likely to develop asthma, but there is no evidence that the exposure to antibiotic is associated with increased risk of asthma exacerbations.

Cited by 80 publications

References 23 publications

The role of gut microbiota in atopic asthma and allergy, implications in the understanding of disease pathogenesis

The role of gut microbiota in atopic asthma and allergy, implications in the understanding of disease pathogenesis

The crosstalk between microbiome and asthma: Exploring associations and challenges

Pediatric Pulmonology year in review 2017: Part 3

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