Early kinetics of heart-type fatty acid binding protein in patients undergoing dipyridamole stress echocardiography and relationship with high-sensitivity troponin

Lippi, Giuseppe; Dipalo, Mariella; Aloe, Rosalia; Robuschi, Fiorenza; Scioscioli, Francesco; Ruffini, Livia; Cervellin, Gianfranco

doi:10.5603/kp.a2014.0043

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…10 13 We did not find any difference between the patients with mTBI with or without CT findings and orthopedic patients. The kinetics of H-FABP seems to be fast 21 and would require blood sampling within a few hours of the injury, and the sampling time exceeded this in most of our patients.…”

Section: Discussionmentioning

confidence: 89%

“…We did not find any difference between the patients with mTBI with or without CT findings and orthopaedic patients. The kinetics of H-FABP seems to be fast20 and would require blood sampling within a few hours of the injury, and the sampling time exceeded this in most of our patients. H-FABP however is not brain specific as higher levels of H-FABP are observed in patients with polytrauma compared with patients with isolated TBI 21.…”

Section: Discussionmentioning

confidence: 89%

“…23 Half-life time for H-FABP is not well studied, likely just a few hours. 21 Half-life time of NF-L seems to be the longest of the studied biomarkers. 23 The finding of higher level of IL-10 in moTBI than in sTBI is somewhat contradictory to the finding of higher level of NF-L in sTBI than in moTBI as the peak time of NF-L appears later.…”

Section: Discussionmentioning

confidence: 97%

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Potential of heart fatty-acid binding protein, neurofilament light, interleukin-10 and S100 calcium-binding protein B in the acute diagnostics and severity assessment of traumatic brain injury

et al. 2021

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BackgroundThere is substantial interest in blood biomarkers as fast and objective diagnostic tools for traumatic brain injury (TBI) in the acute setting.MethodsAdult patients (≥18) with TBI of any severity and indications for CT scanning and orthopaedic injury controls were prospectively recruited during 2011–2013 at Turku University Hospital, Finland. The severity of TBI was classified with GCS: GCS 13–15 was classified as mild (mTBI); GCS 9–12 as moderate (moTBI) and GCS 3–8 as severe (sTBI). Serum samples were collected within 24 hours of admission and biomarker levels analysed with high-performance kits. The ability of biomarkers to distinguish between severity of TBI and CT-positive and CT-negative patients was assessed.ResultsAmong 189 patients recruited, neurofilament light (NF-L) was obtained from 175 patients with TBI and 40 controls. S100 calcium-binding protein B (S100B), heart fatty-acid binding protein (H-FABP) and interleukin-10 (IL-10) were analysed for 184 patients with TBI and 39 controls. There were statistically significant differences between levels of all biomarkers between the severity classes, but none of the biomarkers distinguished patients with moTBI from patients with sTBI. Patients with mTBI discharged from the ED had lower levels of IL-10 (0.26, IQR=0.21, 0.39 pg/mL), H-FABP (4.15, IQR=2.72, 5.83 ng/mL) and NF-L (8.6, IQR=6.35, 15.98 pg/mL) compared with those admitted to the neurosurgical ward, IL-10 (0.55, IQR=0.31, 1.42 pg/mL), H-FABP (6.022, IQR=4.19, 20.72 ng/mL) and NF-L (13.95, IQR=8.33, 19.93 pg/mL). We observed higher levels of H-FABP and NF-L in older patients with mTBI. None of the biomarkers or their combinations was able to distinguish CT-positive (n=36) or CT-negative (n=58) patients with mTBI from controls.ConclusionsS100B, H-FABP, NF-L and IL-10 levels in patients with mTBI were significantly lower than in patients with moTBI and sTBI but alone or in combination, were unable to distinguish patients with mTBI from orthopaedic controls. This suggests these biomarkers cannot be used alone to diagnose mTBI in trauma patients in the acute setting.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 89%

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Potential of heart fatty-acid binding protein, neurofilament light, interleukin-10 and S100 calcium-binding protein B in the acute diagnostics and severity assessment of traumatic brain injury

et al. 2021

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Effect of dobutamine stress echocardiography on serum heart fatty acid binding protein levels

et al. 2017

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Early kinetics of heart-type fatty acid binding protein in patients undergoing dipyridamole stress echocardiography and relationship with high-sensitivity troponin

Abstract: These results suggest that dipyridamole stress echocardiography does not trigger substantial myocardial injury. We have also shown that release of H-FABP from stressed myocardium occurs without progression towards irreversible necrosis, and is more precious than that of TnI.

Cited by 2 publications

References 15 publications

Potential of heart fatty-acid binding protein, neurofilament light, interleukin-10 and S100 calcium-binding protein B in the acute diagnostics and severity assessment of traumatic brain injury

Potential of heart fatty-acid binding protein, neurofilament light, interleukin-10 and S100 calcium-binding protein B in the acute diagnostics and severity assessment of traumatic brain injury

Effect of dobutamine stress echocardiography on serum heart fatty acid binding protein levels

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