Effect of dobutamine stress echocardiography on serum heart fatty acid binding protein levels

Akıncı, Si̇nan; Balcıoğlu, Akif Serhat; Taçoy, Gülten; Tavıl, Yusuf; Gülbahar, Özlem; Özdemir, Murat

doi:10.1080/00015385.2017.1291181

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Therefore, it seems advisable to combine H-FABP testing with another, more specific biomarker or another test for CAD, such as stress echocardiography. This was confirmed in a recent study by Akinci et al where serum H-FABP levels increased significantly at 1 h in the presence of ischemia induced by dobutamine stress echocardiography in patients with stable clinical coronary syndromes [34]. As the authors pointed out, adding H-FABP measurements to pharmacologic stress tests may improve their diagnostic accuracy.…”

Section: Heart-type Fatty Acid Binding Protein (H-fabp)supporting

confidence: 55%

Circulating biomarkers in the setting of stress test-induced myocardial ischemia – a review of potential candidates for introduction into clinical practice

Zandecki,

Zachura,

Barańska

et al. 2024

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The essential goal in the diagnostic approach to chronic coronary syndromes is to identify patients with significant stenoses in the coronary arteries who could benefit from invasive treatment while avoiding exposure to unnecessary interventional treatments or diagnostic procedures for patients who are unlikely to have significant stenoses in their coronary arteries. Early myocardial ischemia leads to a dynamic molecular response in the affected myocardium. A promising minimally invasive strategy is to access changes of concentrations of certain biomarkers circulating in blood during stress test-induced myocardial ischemia. This novel approach may change the landscape of non-invasive assessment of cardiac ischemia. However, there is a need for careful selection of possible candidates to be evaluated in future clinical trials. Several biomarkers have been proposed as potentially useful in this context and they are discussed in this review paper. StreszczeniePodstawowym celem w diagnostyce przewlekłych zespołów wieńcowych jest identyfikacja pacjentów z istotnymi zwężeniami w tętnicach wieńcowych, którzy mogliby odnieść korzyść z leczenia inwazyjnego, unikając jednocześnie narażenia na niepotrzebne inwazyjne procedury diagnostyczne lub lecznicze pacjentów, którzy prawdopodobnie nie mają istotnych zwężeń w tętnicach wieńcowych. Niedokrwienie mięśnia sercowego już na wczesnym etapie prowadzi do dynamicznej odpowiedzi na poziomie molekularnym. Obiecującą minimalnie inwazyjną strategią jest ocena zmian stężeń pewnych biomarkerów krążących we krwi podczas niedokrwienia mięśnia sercowego wywołanego testem wysiłkowym. To nowatorskie podejście może zmienić strategie nieinwazyjnej oceny niedokrwienia serca. Potrzebna jest staranna selekcja potencjalnych kandydatów do oceny w badaniach klinicznych. Co najmniej kilka biomarkerów zaproponowano jako potencjalnie użyteczne w tym zakresie i omówiono w niniejszym artykule przeglądowym.

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Section: Heart-type Fatty Acid Binding Protein (H-fabp)supporting

confidence: 55%

Circulating biomarkers in the setting of stress test-induced myocardial ischemia – a review of potential candidates for introduction into clinical practice

Zandecki,

Zachura,

Barańska

et al. 2024

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“…The authors concluded that cTn-I remained the best single test, with the incremental diagnostic sensitivity of serum H-FABP, but not copeptin. Furthermore, a recent dobutamine stress echocardiography (DSE) study reported significantly increased levels of serum H-FABP at 1 hour in the presence of DSE-induced ischemia, in contrast to DSE negative group, whose serum H-FABP remained unchanged before and 1 hour after the test 24 . However, in a study that was expected H-FABP to increase during exercise stress testing (EST), serum H-FABP tended to decline statistically significant from the basal level to 3 hours after the EST 25 .…”

Section: Discussionmentioning

confidence: 99%

The prognostic significance of heart-type fatty acid binding protein in patients with stable coronary heart disease

Tseng

et al. 2018

Sci Rep

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To investigate the prognostic value of heart-type fatty acid binding protein (H-FABP) in patients with stable coronary heart disease (SCHD). A total of 1,071 patients with SCHD were prospectively enrolled in this Taiwan multicenter registry study, followed for 24 months. The cut-off value of H-FABP, 4.143 pg/mL, was determined using receiver operating characteristic curves. The primary cardiovascular (CV) outcome was composite CV events, defined as cardiovascular or cerebrovascular death, myocardial infarction (MI), stroke, angina related-hospitalization, PAOD-related hospitalization and heart failure. Secondary outcomes included CV or cerebrovascular death, nonfatal MI, nonfatal stroke, and acute heart failure-related hospitalization. We found that the high H-FABP group had more than a two-fold higher rate of primary CV outcomes than the low H-FABP group (32.36% vs. 15.78%, p < 0.001). Eleven patients (4.82%) of the high H-FABP group died during the 24 months of follow-up, compared to only one patient (0.12%) in the low H-FABP group. The acute heart failure-related hospitalization rate was also significantly higher in the high H-FABP group (3.5% vs. 0.95%, p < 0.005). The results remained significant after adjusting for baseline covariates. In conclusion, H-FABP was an independent predictor for CV outcomes in the patients with SCHD, mainly in CV death and acute heart failure-related hospitalization.

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“…A detectable level is reached in the initial period of myocardial necrosis, which means that H-FABP is a sensitive and reliable biomarker that can be used for the early detection of myocardial injury. In patients with perioperative myocardial infarction (PMI), the level of H-FABP is high and it can be used as an earlier telltale sign than the cTnI biomarker to differentiate between patients with and without perioperative myocardial infarction one hour after CABG, compared to increased cTnI levels after about 12 h [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

H-FABP Levels and Psycho-Emotional Improvement of CABG Patients during Cardiac Rehabilitation

Namat

Ciocoiu

et al. 2022

JCDD

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(1) Background: The heart-type fatty acid-binding protein (H-FABP) is a specific myocardial biomarker and high levels indicate ischemia regardless of patient-reported symptoms. Concurrently, major adverse cardiovascular events and surgery such as coronary artery by-pass grafting (CABG) cause substantial psycho-emotional distress e.g., depression and anxiety. Comprehensive cardiac rehabilitation is, therefore, essential to both physical and psychological recovery. (2) Methods: This is a unicentric, prospective study on 120 consecutive post-CABG patients undergoing a 6-month cardiac rehabilitation program based on physical exercise, Mediterranean diet principles, and Q10 coenzyme antioxidant supplements. H-FABP levels, depression, and anxiety scores (Hamilton HAM-D and HAM-A scales) were monitored after surgery and at 6 months. (3) Results: Mean H-FABP dropped from 60.56 to 4.81. Physical ability increased from 1–2 to 4–5 METS. Mean depression and anxiety improved from 15.88 to 6.96 and from 25.13 to 15.68, respectively. Median scores went down 50% for depression and 9% for anxiety. Explored associations between H-FABP and psycho-emotional status were statistically insignificant. (4) Conclusions: patients adhered to the program and improved significantly in all studied aspects. Clinical significance is discussed in the context of countries like Romania, where such programs are limited by systemic and financial constraints. Further research directions are identified.

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Effect of dobutamine stress echocardiography on serum heart fatty acid binding protein levels

Cited by 3 publications

References 18 publications

Circulating biomarkers in the setting of stress test-induced myocardial ischemia – a review of potential candidates for introduction into clinical practice

Circulating biomarkers in the setting of stress test-induced myocardial ischemia – a review of potential candidates for introduction into clinical practice

The prognostic significance of heart-type fatty acid binding protein in patients with stable coronary heart disease

H-FABP Levels and Psycho-Emotional Improvement of CABG Patients during Cardiac Rehabilitation

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