Early involvement of the tegmentopontine reticular nucleus during the evolution of Alzheimer’s disease-related cytoskeletal pathology

U, Rüb; Schultz, Christian; Tredici, Kelly Del; Braak, Heiko

doi:10.1016/s0006-8993(01)02598-7

Cited by 19 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…found that individuals who suffer from AD undergo deterioration of the suprachiasmatic nucleus, which results in a dysfunction of the timekeeping system, and Rüb et al . found that neurons of the brainstem are damaged in the early stage of AD, which generates pathological sleepiness . Conversely, Elwood et al .…”

Section: Discussionmentioning

confidence: 97%

Excessive daytime sleepiness is related to subjective memory impairment in late life: a cross‐sectional community‐based study

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

Excessive daytime sleepiness is related to subjective memory impairment in late life: a cross‐sectional community‐based study

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The reticulotegmental nucleus of the pons is an important component of the oculomotor circuit that regulates horizontal saccades and smooth pursuit movements of the eyes (Keller and Crandall, 1981; Büttner-Ennever and Horn, 1997). Damage to the reticulotegmental nucleus has been observed in spinocerebellar ataxia (Rüb et al, 2004) and it most probably contributes to hypometric horizontal saccades and slowing of smooth pursuits that characteristically develop in patients suffering from Alzheimer’s disease (Rüb et al, 2001). Therefore, non-invasive assessment of these nuclei may help to improve diagnosis and understanding of these diseases.…”

Section: Discussionmentioning

confidence: 99%

High-Resolution MR Imaging of the Human Brainstem In vivo at 7 Tesla

Deistung

Schäfer

Schweser

et al. 2013

Front. Hum. Neurosci.

View full text Add to dashboard Cite

The human brainstem, which comprises a multitude of axonal nerve fibers and nuclei, plays an important functional role in the human brain. Depicting its anatomy non-invasively with high spatial resolution may thus in turn help to better relate normal and pathological anatomical variations to medical conditions as well as neurological and peripheral functions. We explored the potential of high-resolution magnetic resonance imaging (MRI) at 7 T for depicting the intricate anatomy of the human brainstem in vivo by acquiring and generating images with multiple contrasts: T2-weighted images, quantitative maps of longitudinal relaxation rate (R1 maps) and effective transverse relaxation rate (Rnormal2normal* maps), magnetic susceptibility maps, and direction-encoded track-density images. Images and quantitative maps were compared with histological stains and anatomical atlases to identify nerve nuclei and nerve fibers. Among the investigated contrasts, susceptibility maps displayed the largest number of brainstem structures. Contrary to R1 maps and T2-weighted images, which showed rather homogeneous contrast, Rnormal2normal* maps, magnetic susceptibility maps, and track-density images clearly displayed a multitude of smaller and larger fiber bundles. Several brainstem nuclei were identifiable in sections covering the pons and medulla oblongata, including the spinal trigeminal nucleus and the reticulotegmental nucleus on magnetic susceptibility maps as well as the inferior olive on R1, Rnormal2normal*, and susceptibility maps. The substantia nigra and red nuclei were visible in all contrasts. In conclusion, high-resolution, multi-contrast MR imaging at 7 T is a versatile tool to non-invasively assess the individual anatomy and tissue composition of the human brainstem.

show abstract

“…Eye movements are controlled by an intricate neural network involving brainstem nuclei and the cerebral cortex and degenerative changes in several sites in this network may explain the eye movement deficiency reported in AD [372]. However, it is of interest that a reduction in LC activity may also contribute to the eye movement disorders.…”

Section: Pathological Alterations Of Locus Coeruleus Activitymentioning

confidence: 99%

Functional Neuroanatomy of the Noradrenergic Locus Coeruleus: Its Roles in the Regulation of Arousal and Autonomic Function Part II: Physiological and Pharmacological Manipulations and Pathological Alterations of Locus Coeruleus Activity in Humans

Samuels

Szabadi²

2008

383

365

View full text Add to dashboard Cite

The locus coeruleus (LC), the major noradrenergic nucleus of the brain, gives rise to fibres innervating most structures of the neuraxis. Recent advances in neuroscience have helped to unravel the neuronal circuitry controlling a number of physiological functions in which the LC plays a central role. Two such functions are the regulation of arousal and autonomic activity, which are inseparably linked largely via the involvement of the LC. Alterations in LC activity due to physiological or pharmacological manipulations or pathological processes can lead to distinct patterns of change in arousal and autonomic function. Physiological manipulations considered here include the presentation of noxious or anxiety-provoking stimuli and extremes in ambient temperature. The modification of LC-controlled functions by drug administration is discussed in detail, including drugs which directly modify the activity of LC neurones (e.g., via autoreceptors, storage, reuptake) or have an indirect effect through modulating excitatory or inhibitory inputs. The early vulnerability of the LC to the ageing process and to neurodegenerative disease (Parkinson’s and Alzheimer’s diseases) is of considerable clinical significance. In general, physiological manipulations and the administration of stimulant drugs, α2-adrenoceptor antagonists and noradrenaline uptake inhibitors increase LC activity and thus cause heightened arousal and activation of the sympathetic nervous system. In contrast, the administration of sedative drugs, including α2-adrenoceptor agonists, and pathological changes in LC function in neurodegenerative disorders and ageing reduce LC activity and result in sedation and activation of the parasympathetic nervous system.

show abstract

Early involvement of the tegmentopontine reticular nucleus during the evolution of Alzheimer’s disease-related cytoskeletal pathology

Cited by 19 publications

References 28 publications

Excessive daytime sleepiness is related to subjective memory impairment in late life: a cross‐sectional community‐based study

Excessive daytime sleepiness is related to subjective memory impairment in late life: a cross‐sectional community‐based study

High-Resolution MR Imaging of the Human Brainstem In vivo at 7 Tesla

Functional Neuroanatomy of the Noradrenergic Locus Coeruleus: Its Roles in the Regulation of Arousal and Autonomic Function Part II: Physiological and Pharmacological Manipulations and Pathological Alterations of Locus Coeruleus Activity in Humans

Contact Info

Product

Resources

About