Early identification of left ventricular remodelling after myocardial infarction, assessed by transthoracic 3D echocardiography

Mannaerts, Herman F.J.; Heide, J.A. van der; Kamp, Otto; Stoel, Martin G.; Twisk, Jos W. R.; Visser, Cees A.

doi:10.1016/j.ehj.2004.02.030

Cited by 155 publications

(122 citation statements)

References 26 publications

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“…The moderate (MOD) remodeling phenotype was defined as a LVEDV and/or LVESV that was >20% higher than the average value in sham. We used the 20% cutoff change in volume as a marker of more significant remodeling as previously described 14, 15…”

Section: Methodsmentioning

confidence: 99%

Mitochondrial Integrity and Function in the Progression of Early Pressure Overload–Induced Left Ventricular Remodeling

Chaanine

Nair

Bergen

et al. 2017

JAHA

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BackgroundFollowing pressure overload, compensatory concentric left ventricular remodeling (CR) variably transitions to eccentric remodeling (ER) and systolic dysfunction. Mechanisms responsible for this transition are incompletely understood. Here we leverage phenotypic variability in pressure overload–induced cardiac remodeling to test the hypothesis that altered mitochondrial homeostasis and calcium handling occur early in the transition from CR to ER, before overt systolic dysfunction.Methods and ResultsSprague Dawley rats were subjected to ascending aortic banding, (n=68) or sham procedure (n=5). At 3 weeks post–ascending aortic banding, all rats showed CR (left ventricular volumes < sham). At 8 weeks post–ascending aortic banding, ejection fraction was increased or preserved but 3 geometric phenotypes were evident despite similar pressure overload severity: persistent CR, mild ER, and moderate ER with left ventricular volumes lower than, similar to, and higher than sham, respectively. Relative to sham, CR and mild ER phenotypes displayed increased phospholamban, S16 phosphorylation, reduced sodium‐calcium exchanger expression, and increased mitochondrial biogenesis/content and normal oxidative capacity, whereas moderate ER phenotype displayed decreased p‐phospholamban, S16, increased sodium‐calcium exchanger expression, similar degree of mitochondrial biogenesis/content, and impaired oxidative capacity with unique activation of mitochondrial autophagy and apoptosis markers (BNIP3 and Bax/Bcl‐2).ConclusionsAfter pressure overload, mitochondrial biogenesis and function and calcium handling are enhanced in compensatory CR. The transition to mild ER is associated with decrease in mitochondrial biogenesis and content; however, the progression to moderate ER is associated with enhanced mitochondrial autophagy/apoptosis and impaired mitochondrial function and calcium handling, which precede the onset of overt systolic dysfunction.

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Section: Methodsmentioning

confidence: 99%

Mitochondrial Integrity and Function in the Progression of Early Pressure Overload–Induced Left Ventricular Remodeling

Chaanine

Nair

Bergen

et al. 2017

JAHA

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“…Improvement of LV function occurred due to the contraction of the inferior region. The sphericity index was shown as an accurate predictor of LV remodelling in patients after an acute myocardial infarction (9). Studies have shown that Simpson's biplane calculation of EF can vary up to 4.1% between clinicians.…”

Section: Discussionmentioning

confidence: 99%

Real-time 3-dimensional transesophageal echocardiography assessment of left ventricular shape and function after surgical remodelling

Barišin¹

2017

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BackgroundReal-time three dimensional transoesophageal echocardiography (RT 3D-TEE) may better reflect left ventricle (LV) shape and function than cconventional 2D-TEE. The goal of this study was to evaluate the advantages of 3D analysis in shape assessment and to quantify the LV volume by ejection fraction (EF) measurement, after LV surgical remodelling. Methods In a prospective manner, twenty consecutive coronary surgery patients with LV anteroapical aneurysm and functional mitral regurgitation were analyzed by 2D-and thereafter by 3D-TEE before and after surgery. The key intraoperative inclusion criteria was a LVEF < 30% confirmed by intraoperative 3D-TEE immediately before surgical remodeling. Results Before surgery, the geometry of post infarction aneurysm shows negative curvatures of the antero-basal and infero-apical segment and the apex of LV is shifted clockwise, towards the mitral valve. Surgery had significantly reduced the LV volumes and the LVEF had increased by 13.3% as recorded by 2D-TEE and by 18.3% as assessed by 3D-TEE quantification (p < 0.001 for both). Accordingly, the longitudinal plane had been shortened, the apex was now shifted anti-clockwise towards the aorta and the inferior region had taken a more important function of the LV. Significantly lower values were observed in the EF measurement with 3D-vs 2D-TEE before remodelling (22.3 vs. 29.7%, p = 0.048).

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“…Мно-го работ отечественных и зарубежных авторов посвя-щено исследованию таких эхокардиографических па-раметров, как индексы сферичности, индекс напря-жения миокарда, индексы ремоделирования, мио-кардиальный стресс левого желудочка, маркёры диа-столической дисфункции. Считается, что некоторые из этих показателей являются более информативными, чем фракция выброса, размеры и объёмы ЛЖ при оценке тяжести ХСН [5].…”

Section: Discussionunclassified

“…Для оценки ремоделирования сердца при ХСН в по-следнее время стали использоваться такие показатели, как индексы сферичности, миокардиальный стресс, ин- [5], было показано, что индекс сферичности в большей степени, чем фракция выброса, коррелирует с клиническими проявлениями.…”

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Is There an Alternative to Ejection Fraction in Instrumental Evaluation of Chronic Heart Failure Severity in Post-Myocardial Infarction Patients?

Kazakovtseva

Шостак

2010

Racionalʹnaâ farmakoterapiâ v kardiologii

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Early identification of left ventricular remodelling after myocardial infarction, assessed by transthoracic 3D echocardiography

Abstract: Three-dimensional echocardiography can differentiate patients with and without subsequent development of LV remodelling accurately and early on the basis of the 3D sphericity index, a new and highly predictive variable.

Cited by 155 publications

References 26 publications

Mitochondrial Integrity and Function in the Progression of Early Pressure Overload–Induced Left Ventricular Remodeling

Mitochondrial Integrity and Function in the Progression of Early Pressure Overload–Induced Left Ventricular Remodeling

Real-time 3-dimensional transesophageal echocardiography assessment of left ventricular shape and function after surgical remodelling

Is There an Alternative to Ejection Fraction in Instrumental Evaluation of Chronic Heart Failure Severity in Post-Myocardial Infarction Patients?

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