Early identification of acute hypoxia based on brain NADH fluorescence and cerebral blood flow

Abstract

Hypoxia is closely related to many diseases and often leads to death. Early detection and identi¯cation of the hypoxia causes may help to promptly determine the right rescue plan and reduce the mortality. We proposed a new multiparametric monitoring method employing mitochondrial reduced nicotinamide adenine dinucleotide (NADH)°uorescence, regional re°ec-tance, regional cerebral blood°ow (CBF), electrocardiography (ECG), and respiration under six kinds of acute hypoxia in four categories to investigate a correlation between the parameter variances and the hypoxia causes. The variation patterns of the parameters were discussed, and the combination of NADH and CBF may contribute to the identi¯cation of the causes of hypoxia.

Fiber-Optic System for Intraoperative Study of Abdominal Organs during Minimally Invasive Surgical Interventions

“…2019, 9, x FOR PEER REVIEW 3 of 8 method that can be included in multimodal diagnostic devices, and specifically in surgical operations on the organs of the digestive tract [14]. In this study, we have combined FS and LDF measurement techniques in one fibre optical probe to record the parameters of endogenous fluorescence and blood perfusion during minimally invasive interventions [15][16][17]. Thus, the overall aims of this work were to test the technical implementation of such measurements as well as register reference patterns of the fluorescence spectra and blood perfusion time series in organs of hepatopancreatoduodenal zone.…”

Optical biopsy methods and their prospects of application for intraoperative analysis of tissue metabolism and blood microcirculation in minimally invasive surgery

“…Предлагаемый данным коллективом подход предусматривает использование нескольких измерительных каналов с целью определения параметров дыхательной цепи (NADH/FAD) на фоне влияющих факторов. Используя методы абсорбционной спектроскопии, лазерной допплеровской флоуметрии и ФС в рамках одного эксперимента, данный коллектив получил убедительные данные по определению митохондриальной функции в тканях мозга [43].…”