Early hyperbaric oxygen therapy attenuates disease severity in lupus-prone autoimmune (NZB × NZW) F1 mice

Chen, Shao-Yuan; Chen, Yen‐Chen; Wang, Jehng-Kang; Hsu, Hsiao-Ping; Ho, Pey-Shen; Chen, Yi-Chyan; Sytwu, Huey‐Kang

doi:10.1016/s1521-6616(03)00091-3

Cited by 26 publications

(21 citation statements)

References 26 publications

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“…HBO has also been shown to decrease the symptoms of advanced arthritis in rats [36], and it attenuated the inflammatory response in the peritoneal cavity caused by injected meconium [37]. In addition, one study using HBO at 2.5 ATA showed increased survival and decreased proteinuria, anti-dsDNA antibody titers, and immune-complex deposition in lupusprone autoimmune mice [38]. Hence, HBO could be used as an adjuvant therapy for various inflammatory conditions, including necrotizing soft tissue infection, gas gangrene, refractory osteomyelitis, burns, and chronic wounds.…”

Section: Discussionmentioning

confidence: 99%

Human Amniotic Fluid Mesenchymal Stem Cells in Combination with Hyperbaric Oxygen Augment Peripheral Nerve Regeneration

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Human Amniotic Fluid Mesenchymal Stem Cells in Combination with Hyperbaric Oxygen Augment Peripheral Nerve Regeneration

et al. 2009

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“…It would appear more likely that HBO treatment inhibits directly B-cell mediated antibody secretion. In this regard it is interesting to point that in lupus prone mice HBO treatment suppressed the autoantibody production and deposition of immune complexes in the kidney (10, 24). …”

Section: Discussionmentioning

confidence: 99%

Hyperbaric oxygen treatment attenuates the pro-inflammatory and immune responses in apolipoprotein E knockout mice

Kudchodkar

Jones

Simecka

et al. 2008

Clinical Immunology

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Chronic hyperbaric oxygen (HBO) therapy significantly attenuates atherosclerosis in New Zealand white rabbits as well as the apoE knockout (KO) mice, independent of plasma lipid concentrations and lipoprotein profiles. Because atherosclerosis has many features of a chronic inflammatory disease, in which both cell-mediated and humoral immune responses participate, we examined the effect of HBO treatment on various aspects of the immune response. We now demonstrate that in ApoE KO mice, HBO treatment significantly reduces the circulating levels of antibodies to MDA LDL, both in the IgG and IgM class, as well as the delayed hypersensitivity (DTH) response to oxLDL challenge. Furthermore, HBO treatment results in a profound attenuation in the production of pro-inflammatory cytokines in response to an inflammatory stimulus (LPS), which is accompanied by a marked increase in the constitutive production of the anti-inflammatory cytokine IL-10 by spleen cells, independent of antigen specificity, as indicated by polyclonal activation of T cells. Our results demonstrate that HBO treatment results in the dampening of T and B cell mediated responses to oxLDL or inflammatory stimuli.

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“…HBOT has also been shown to decrease the symptoms of advanced arthritis in rats [96] and attenuates the inflammatory response in the peritoneal cavity caused by injected meconium [97]. In addition, one animal study using HBOT at 2.5 ATA showed increased survival and decreased proteinuria, anti-dsDNA antibody titers, and immune-complex deposition in lupus-prone autoimmune mice [98]. Furthermore, HBOT has been used in animal studies to improve colitis [93].…”

Section: Hbot Use In Inflammatory Conditionsmentioning

confidence: 99%

Hyperbaric oxygen therapy may improve symptoms in autistic children

Rossignol

Rossignol²

2006

Medical Hypotheses

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Early hyperbaric oxygen therapy attenuates disease severity in lupus-prone autoimmune (NZB × NZW) F1 mice

Cited by 26 publications

References 26 publications

Human Amniotic Fluid Mesenchymal Stem Cells in Combination with Hyperbaric Oxygen Augment Peripheral Nerve Regeneration

Human Amniotic Fluid Mesenchymal Stem Cells in Combination with Hyperbaric Oxygen Augment Peripheral Nerve Regeneration

Hyperbaric oxygen treatment attenuates the pro-inflammatory and immune responses in apolipoprotein E knockout mice

Hyperbaric oxygen therapy may improve symptoms in autistic children

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