Early healing assessment with optical coherence tomography of everolimus‐eluting stents with bioabsorbable polymer (synergy™) at 3 and 6 months after implantation

Hernández, José M. de la Torre; Tejedor, Paula; Camarero, Tamara García; Durán, Juan Manuel; Lee, Dae‐Hyun; Monedero, Jairo; Laso, Fermín Sáinz; Calderón, Marcos Alvarez; Veiga, Gabriela; Zueco, Javier

doi:10.1002/ccd.26299

Cited by 28 publications

(10 citation statements)

References 19 publications

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“…With the assumption of an average Angiolite stent length of 20 mm, a mean number of eight struts per analyzed cross‐sectional frame, and a 0.5 mm stepping interval for OCT analysis, we estimated to have 8,000 analyzable struts for 3‐month analysis and a further 8,000 struts analyzable at 6‐month analysis if n = 75 patients were to be enrolled (25 patients and 50 patients scheduled for 3‐ and 6‐month OCT follow‐up, respectively). On the basis of the recent published OCT data evaluating stent healing characteristics , we empirically chosed to enroll 75 patients (potentially yielding 24,000 struts for analysis). Assuming a 20% loss to imaging follow‐up rate, we thus planned to enroll a minimum of 100 patients.…”

Section: Methodsmentioning

confidence: 99%

Three‐ and 6‐month optical coherence tomographic surveillance following percutaneous coronary intervention with the Angiolite® drug‐eluting stent: The ANCHOR study

Puri

Otaegui

Sabaté

et al. 2017

Cathet Cardio Intervent

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Section: Methodsmentioning

confidence: 99%

Three‐ and 6‐month optical coherence tomographic surveillance following percutaneous coronary intervention with the Angiolite® drug‐eluting stent: The ANCHOR study

Puri

Otaegui

Sabaté

et al. 2017

Cathet Cardio Intervent

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“…To our knowledge, only one study has to date provided OCT data in 40 patients 3 and 6 months post SYNERGY stent implantation. 22 In this two-centre non-randomised Spanish study, the proportion of uncovered but apposed struts was 2.5% and 1.9% in the 3-month and 6-month group (P=0.03) and the proportion of uncovered and malapposed struts was 3% and 1.8%, respectively (P<0.001). An experimental study in atherosclerotic swines previously showed a very low degree of parastrut inflammation 30 days after implantation of the device.…”

Section: Discussionmentioning

confidence: 75%

Multianalysis with optical coherence tomography and vasomotion in everolimus-eluting stents and everolimus-eluting biovascular scaffolds: the MOVES trial

et al. 2018

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AimsTo compare endothelium-dependent vasomotor function and vascular healing 15 months after implantation of two new-generation drug-eluting stents and biovascular scaffolds (BVS).Methods and resultsA total of 28 patients previously treated with a SYNERGY stent (bioabsorbable polymer everolimus-eluting stents (BP-EES)), a PROMUS stent (persistent polymer everolimus-eluting stents (PP-EES)) or an ABSORB (BVS) underwent control coronary angiography, 15 months after implantation, coupled with optical coherence tomography imaging and supine bicycle exercise. Intracoronary nitroglycerin was administered after exercise testing. Coronary vasomotor response was assessed using quantitative coronary angiography at rest, during supine bicycle exercise and after nitroglycerin. The primary end point was the percent change in mean lumen diameter compared with baseline. Secondary end points were strut coverage and apposition.There were no significant differences in vasomotor response between the three treatment groups. Patients with PP-EES showed significant vasoconstriction of the proximal peristent segment at maximum exercise (P=0.02). BP-EES (2.7%, 95% CI 0 to 5.5) and BVS (3.2%, 95% CI 0 to 6.7) showed less uncovered struts than PP-EES (12.1%, 95% CI 2.9 to 21.3, P=0.02 and 0.09, respectively). Complete strut apposition was more frequently seen with BP-EES (99.6%, 95% CI 99.2 to 100) than with BVS (98.9%, 95% CI 98.2 to 99.6, P=0.04) or PP-EES (95.0%, 95% CI 91.6 to 98.5, P=0.001).ConclusionBVS and thin strut BP-EES have a reassuring vasomotion profile, suggesting minimal endothelial dysfunction 15 months after implantation.

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“…However, in the present study, three stent groups already had about 80% strut coverage, which might indicate a good healing response in strut coverage. In fact, in several studies that investigated patients at 3 months after PCI, the healing outcome of these three stent types was improved [ [27] , [28] , [29] , [30] , [31] ]. Herein, there was no significant difference in OFDI findings and CAS findings, except for PLIA on OFDI.…”

Section: Discussionmentioning

confidence: 99%

The comparison of early healing 1-month after PCI among CoCr-everolimus-eluting stent (EES), biodegradable polymer (BP)-EES and BP-sirolimus-eluting stent: Insights from OFDI and coronary angioscopy

Sato

Taya

Suzuki

et al. 2018

IJC Heart & Vasculature

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BackgroundThird-generation stents with abluminal biodegradable polymer (BP) might facilitate early healing. Therefore, we compared early healing between second-generation and third-generation stents using coronary angioscopy (CAS) and optical frequency domain imaging [OFDI].MethodsWe prospectively enrolled 30 consecutive patients with stent implantation for acute coronary syndrome (cobalt‑chromium [CoCr] everolimus-eluting stent [EES] [n = 10], BP-EES [n = 10], and BP-sirolimus eluting stent [SES] [n = 10]). All patients underwent CAS and OFDI 1 month after initial percutaneous coronary intervention. On OFDI, the stent coverage (SC), thrombus, and peri-strut low intensity area (PLIA) were assessed. CAS findings were recorded for the grade of SC, grade of yellow color (YC), and grade of the thrombus (TG).ResultsOn OFDI, the incidences of any thrombus at the 1-month follow-up were 70%, 80%, and 80% in the CoCr-EES, BP-EES, and BP-SES groups, respectively. The percentage of coverage was comparable among the groups (CoCr-EES 79.8 vs. BP-EES 79.9 vs. BP-SES 80.1%, P = 0.96). However, the number of struts with PLIA was numerically higher in the BP-SES group than in the CoCr-EES and BP-EES groups (46.4 ± 25.1 vs. 21.6 ± 13.2 vs. 22.0 ± 7.2%, P = 0.08). In the CoCr-EES, BP-EES, and BP-SES groups, mean grades of SC were 1.25 ± 0.5, 1.25 ± 0.5, and 0.85 ± 0.70 (P = 0.60); mean grades of YC were 0.75 ± 0.5, 0.80 ± 0.45, and 0.88 ± 0.37 (P = 0.65), and mean grades of TG were 1.00 ± 1.00, 1.20 ± 0.83, and 0.88 ± 0.64 (P = 0.75), respectively.ConclusionThird-generation stents are not inferior to second-generation stents regarding stent coverage. However, PLIA on OFDI was often observed with BP-SESs, indicating involvement of the fibrin component.

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Early healing assessment with optical coherence tomography of everolimus‐eluting stents with bioabsorbable polymer (synergy™) at 3 and 6 months after implantation

Abstract: The everolimus-eluting stent with absorbable polymer, Synergy™, is associated to a high degree of intimal coverage and apposition at 3 months after implantation with additional increase at 6 months. © 2015 Wiley Periodicals, Inc.

Cited by 28 publications

References 19 publications

Three‐ and 6‐month optical coherence tomographic surveillance following percutaneous coronary intervention with the Angiolite® drug‐eluting stent: The ANCHOR study

Three‐ and 6‐month optical coherence tomographic surveillance following percutaneous coronary intervention with the Angiolite® drug‐eluting stent: The ANCHOR study

Multianalysis with optical coherence tomography and vasomotion in everolimus-eluting stents and everolimus-eluting biovascular scaffolds: the MOVES trial

The comparison of early healing 1-month after PCI among CoCr-everolimus-eluting stent (EES), biodegradable polymer (BP)-EES and BP-sirolimus-eluting stent: Insights from OFDI and coronary angioscopy

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