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In this real-life study, 32% of patients received an inappropriate dose of DOAC. Several clinical factors can identify patients at risk of this situation.

The 3-year clinical follow-up of the RIBS V clinical trial confirms the sustained safety and efficacy of EES and DEB in patients treated for bare-metal stent ISR. In this setting, EES reduce the need for target lesion revascularization at very long-term follow-up. (RIBS V [Restenosis Intra-Stent of Bare Metal Stents: Paclitaxel-Eluting Balloon vs Everolimus-Eluting Stent] [RIBS V]; NCT01239953).

In a real-world population, treatment of ISR (including 48% DES-ISR) with this DEB provides good mid-term results with 12% TLR at 1 year, especially in ISR pattern IC (9% MACE).

Manuscript-changes in yellowClick here to access/download;Manuscript;MANUSCRIPT COMBAT MI-BRC-DEF_yellow marked.docx Click here to view linked References Acknowledgements: The COMBAT-MI trial was conceived, designed and led by Prof. David Garcia-Dorado and represents the last contribution of his scientific and medical career dedicated entirely to the search for new and effective cardioprotective strategies that can benefit patients with ischemic heart disease. With this article we want to pay a heartfelt tribute to his memory and express our gratitude to him. The authors also want to thank Prof. Aurora García-Dorado for her valuable and expert assistance in the statistical analysis. The trial was sponsored with a grant from Instituto de Salud Carlos III (PIE 13/00027) and a grant from Generalitat de Catalunya (PERIS SLT/2381/2016).