Early Growth Hormone Intervention Improves Glucose Metabolism in Adult Rats Born Small for Gestational Age

Wang, Yingmin; Zhu, Weifen; Chen, Lianhui; Liang, Li

doi:10.1055/a-0723-3544

Cited by 4 publications

(3 citation statements)

References 33 publications

(40 reference statements)

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“…We found that 3 differentially methylated genes ( PDX1, DECR1 and GNAS ) had been previously associated with SGA, [ 21 , 22 ] suggesting (at least in part) the changes of some genes in SGA and LGA were similar in some pathways and regulatory effects. In this study, the largest methylation difference was demonstrated in the promoter region of the FKBP11 gene.…”

Section: Discussionmentioning

confidence: 89%

Differences of DNA methylation patterns in the placenta of large for gestational age infant

et al. 2020

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Section: Discussionmentioning

confidence: 89%

Differences of DNA methylation patterns in the placenta of large for gestational age infant

et al. 2020

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“…GH deficiency showed small mandibles [43]. Rats that were small for gestational age showed reduced body weight with increased HDAC and could be treated by exogenous GH administration [44]. The administration of trichostatin A, which is an HDACi, increased GH-mRNA expression level in pituitary cells [45].…”

Section: Discussionmentioning

confidence: 99%

Effects of 4-Hexylresorcinol on Craniofacial Growth in Rats

Lee

Kim

et al. 2021

IJMS

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4-Hexylresorcinol (4HR) has been used as a food additive, however, it has been recently demonstrated as a Class I histone deacetylase inhibitor (HDACi). Unlike other HDACi, 4HR can be taken through foods. Unfortunately, some HDACi have an influence on craniofacial growth, therefore, the purpose of this study was to evaluate the effects of 4HR on craniofacial growth. Saos-2 cells (osteoblast-like cells) were used for the evaluation of HDACi and its associated activities after 4HR administration. For the evaluation of craniofacial growth, 12.8 mg/kg of 4HR was administered weekly to 4 week old rats (male: 10, female: 10) for 12 weeks. Ten rats were used for untreated control (males: 5, females: 5). Body weight was recorded every week. Serum and head samples were collected at 12 weeks after initial administration. Craniofacial growth was evaluated by micro-computerized tomography. Serum was used for ELISA (testosterone and estrogen) and immunoprecipitation high-performance liquid chromatography (IP-HPLC). The administration of 4HR (1–100 μM) showed significant HDACi activity (p < 0.05). Body weight was significantly different in male rats (p < 0.05), and mandibular size was significantly smaller in 4HR-treated male rats with reduced testosterone levels. However, the mandibular size was significantly higher in 4HR treated female rats with increased growth hormone levels. In conclusion, 4HR had HDACi activity in Saos-2 cells. The administration of 4HR on growing rats showed different responses in body weight and mandibular size between sexes.

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“…A rat model of SGA was established in animals under maternal undernutrition during pregnancy as previously described ( 21 , 22 ). In brief, adult SPF-grade Sprague-Dawley female (n=15) and male (n=5) rats were mated overnight.…”

Section: Methodsmentioning

confidence: 99%

The Impact of Gut Microbiome on Metabolic Disorders During Catch-Up Growth in Small-for-Gestational-Age

Wang

Yuan

et al. 2021

Front. Endocrinol.

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ObjectiveCatch-up growth (CUG) in small for gestational age (SGA) leads to increased risk of metabolic syndrome and cardiovascular diseases in adults. It remains unclear if microbiota could play an important role in CUG-SGA independent of genetic or nutritional factors. The present study explored the role of gut microbiota in, and its association with, metabolic disorders during CUG-SGA.MethodsAn SGA rat model was established by restricting food intake during pregnancy, and the rats were divided into catch-up growth (CUG-SGA) and non-catch-up growth (NCUG-SGA) groups based on body weight and length at the fourth postnatal week. High-throughput sequencing of 16S rRNA was conducted to detect the diversity and composition of the gut microbiota. Fecal short-chain fatty acids (SCFAs) were detected by gas chromatography-mass spectrometry. Transcriptome sequencing of liver tissue was performed and verified using real-time PCR. Concentrations of insulin and total cholesterol were determined using enzyme-linked immunosorbent assay.ResultsThe composition of gut microbiota in CUG-SGA rats differed from that of NCUG-SGA rats, with reduced abundance of Lactobacillus in the CUG-SGA group. The decrease in Lactobacillus was significantly associated with increased body weight and upregulated insulin and total cholesterol levels. Five SCFAs and two branched chain fatty acids were significantly higher in the CUG-SGA group than in the NCUG-SGA group. Additionally, SCFAs were positively associated with clinical indices such as weight, body mass index, insulin, and total cholesterol. Transcriptomic data revealed that insulin-like growth factor-2 expression was significantly decreased in CUG-SGA rats and was associated with a decrease in Lactobacillus bacteria.ConclusionLactobacillus and SCFAs were associated with the metabolic disorders during CUG in SGA. Gut microbiome may play a certain role on metabolic disorders during catch-up growth in small-for-gestational-age.

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Early Growth Hormone Intervention Improves Glucose Metabolism in Adult Rats Born Small for Gestational Age

Cited by 4 publications

References 33 publications

Differences of DNA methylation patterns in the placenta of large for gestational age infant

Differences of DNA methylation patterns in the placenta of large for gestational age infant

Effects of 4-Hexylresorcinol on Craniofacial Growth in Rats

The Impact of Gut Microbiome on Metabolic Disorders During Catch-Up Growth in Small-for-Gestational-Age

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