Early Failure of Expanded Polytetrafluoroethylene in Femoral Vein Replacement

Personalized tissue-engineered veins – long term safety, functionality and cellular transcriptome analysis in large animals

“…Conduits for venous reconstructions have both early and late patency problems due to thrombosis. [9][10][11][12][13][14][15] Even for autologous vein conduits, earlier experiences from treatments to overcome chronic venous obstruction or deep vein insufficiency, are associated with poor patency. 11 Low flow velocity has been suggested to promote vein thrombosis but also vessel wall ischemia due to loss of the vasa vasorum circulation caused by transposition of the vein can explain graft failure.…”

“…Different graft substitutes, including cryopreserved or decellularized allogenic veins, vein conduits constructed of bovine pericardium or PTFE grafts have been evaluated, e.g., for chronic venous obstruction or deep vein insufficiency, but all have had issues with long-term patency. [9][10][11][12][13][14][15] We have recently, in a short-term in vivo pig safety study of vena cava transplantation shown that biological individualized vascular vein graft has potential to be a viable option for patients in need of restoration of crucial venous function. 16 This technique involves decellularization of native blood vessels from human or animal donors followed by reconditioning with autologous peripheral blood to generate individualized tissue-engineered vascular grafts.…”

“…, for chronic venous obstruction or deep vein insufficiency, but all have had issues with long-term patency. 9–15…”

Use of a Superficial Femoral Artery Autograft as a Femoral Vein Replacement

“…Prosthetic grafts have disadvantages like poor long-term patency rates and predisposition to thrombosis because of low pressure, low-velocity blood flow, and the inherent thrombogenicity of prosthetic materials particularly in the venous system. 3 Finding an autologous vein graft to provide the same size of longitudinally dilated native vein is not always possible. Spiral vein grafts could also be used for SFV; however, it is not a practical solution and needs another incision at the contralateral leg for vein harvesting, which may cause delayed mobilization of the patient.…”

Neo-intima-nachweis nach experimentellem venenersatz durch PTFE-prothesen beim hund

“…Die Thrombosierung nach alloplastischem Venenersatz trat in tier Regel 24-28 h nach der Implantation auf [5]. 7a-f auskleidung, hohe Elastizitfit) -wie bereits an einigen Beispielen aufgezeigt wurde -nicht fiJr den Venenersatz.…”