Neo-intima-nachweis nach experimentellem venenersatz durch PTFE-prothesen beim hund

Abstract

Because of the danger of thrombosis, venous replacement by prostheses is a yet clinically unsolved problem. We tested the PTFE-prosthesis at the positions of vena cava inferior and iliac veins in dogs. Already eight weeks after operation, the inner surface of the prosthesis was covered by a thin neo-intima, which by light microscopy, scanning and transmission electron microscopy was shown to contain a basal membrane and endothelial cells. This continuous layer may be responsible for the observed low rate of thrombosis. These findings suggest that the PTFE-prosthesis may offer advantages for venous replacement in patients.

Experimental studies of the porosity of the alloplastic vein replacement

“…It is mostly a question here of the replacement of the superior vena cava, the inferior v. c. or the pelvic veins [3,6,14,15,19,20].…”

“…These studies all showed a very rapid and complete endothelial lining (within 6-8 weeks) [3,4,5,14,15,19,20].…”

“…The protective effect of a heparinization or an inhibition of platelet aggregation during the incorporation phase is undisputed [4,6,7,13,19]. The same applies to an increase in the flow speed and circulatory rate which, according to the resuits of various investigators, has a clearly protective effect on a vein-replacement operation [6,13,16].…”