Early Experiences with Ultrasonic Irradiation of the Pallidofugal and Nigral Complexes in Hyperkinetic and Hypertonic Disorders

Meyers, Russell; Fry, William J.; Fry, F. J.; Dreyer, Leroy L.; Schultz, D. F.; Noyes, Robert F.

doi:10.3171/jns.1959.16.1.0032

Cited by 157 publications

(64 citation statements)

References 36 publications

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“…Ultrasound transducers are capable of focusing acoustic waves on targets located deep within tissues. By manipulating the sonication parameters, focused ultrasound is capable of thermal tissue ablation, mechanical tissue ablation (histotripsy), neuromodulation, and BBB disruption, and thus has many potential applications in the treatment of brain disease (97)(98)(99)(100)(101)(102)(103)(104)(105). Although early studies showed the promise of focused ultrasound for the treatment of intracranial disorders, obstacles associated with the control and monitoring of the procedure coupled with the limitations associated with application of acoustic waves through the skull have, until recently, impeded the widespread application of this technology in neuro-oncology.…”

Section: Transcranial Mr-guided-focused Ultrasound Surgerymentioning

confidence: 99%

Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part V: Clinically Relevant Model for Testing New Therapeutic Approaches

Rossmeisl

2017

Glioblastoma

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A significant obstacle to the development of new brain tumor therapeutics remains the lack of rodent models that faithfully reproduce the in vivo complexities of human glioblastoma. Dogs and humans are the only species that frequently develop spontaneous brain tumors. Remarkable clinical, phenotypic, and molecular similarities exist between human and canine malignant glioma. Our research has focused on the development of pharmacologically tractable molecular targets common to human and canine gliomas, as well as the discovery Canine Brain Tumor Models 406 and refinement of novel methods of drug delivery to the brain, such as convection-enhanced delivery (CED), irreversible electroporation (IRE), and focused ultrasound, that can overcome the limitations imposed by the bloodbrain and blood-tumor barriers. Through the conduct of early phase clinical trials in dogs, we demonstrate the safety, feasibility, and preliminary efficacies of IL-13RA2-and EphA2-targeted bacterial cytotoxins and IRE for the treatment of spontaneous malignant glioma, illustrate the clinical utility of real-time imaging monitored CED as a robust drug delivery platform, and describe the use of the tumor-bearing dog in transcranial-focused ultrasound applications related to neuro-oncology. The dog brain cancer model offers unique opportunities to expedite the clinical translation of cancer therapeutics through the design of preclinical investigations that ask and answer drug and medical device development questions that cannot be sufficiently addressed in rodent models.

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Section: Transcranial Mr-guided-focused Ultrasound Surgerymentioning

confidence: 99%

Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part V: Clinically Relevant Model for Testing New Therapeutic Approaches

Rossmeisl

2017

Glioblastoma

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“…X-ray imaging was used. Despite the promising results, the development of the method was abandoned due to the difficulties related to the exact localization of brain structures for ablation and the introduction of levodopa, which brought good results with fewer treatment complications 10 . The following years resulted in theoretical studies, indicating the potential benefits of non-invasive neurosurgery using focused ultrasound.…”

Section: Historymentioning

confidence: 99%

MR-Guided Focused Ultrasound: A New Generation Treatment of Parkinson's Disease, Essential Tremor and Neuropathic Pain

et al. 2014

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The application of high intense focused ultrasound (HIFU) is currently the subject of many experimental and clinical trials. The combination of HIFU with MRI guidance known as MR-guided focused ultrasound (MRgFUS) appears to be particularly promising to ablate tissues located deep in the brain. The method can be the beginning of interventional neurology and an important alternative to neurosurgery. Studies conducted to date show the effectiveness of the method both in chronic diseases and in emergency cases. The safety and effectiveness of this method have been observed in parkinsonian and essential tremor as well as in neuropathic pain. The procedure does not require anaesthesia. Ionizing radiation is not used and there is no risk of cumulative dose. Such advantages may result in low complication rates and medical justification for further development of MRgFUS.

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“…Beyond that, there are the beginnings of the ultrasound field in the 1920s by Wood and Loomis involving biological specimens (Wood and Loomis, 1927) and the prodigious work led by W.J. Fry in the 1950s and 1960s, University of Illinois, which studied in great detail, the effects of high intensity ultrasound in laboratory studies and initiated the field of neurosonicsurgery (Fry et al, 1958;Meyers et al, 1959;Hickey et al, 1961;Fry and Meyers, 1962).…”

Section: Prefacementioning

confidence: 99%

Emerging Therapeutic Ultrasound

Vogt¹

2006

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Early Experiences with Ultrasonic Irradiation of the Pallidofugal and Nigral Complexes in Hyperkinetic and Hypertonic Disorders

Cited by 157 publications

References 36 publications

Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part V: Clinically Relevant Model for Testing New Therapeutic Approaches

Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part V: Clinically Relevant Model for Testing New Therapeutic Approaches

MR-Guided Focused Ultrasound: A New Generation Treatment of Parkinson's Disease, Essential Tremor and Neuropathic Pain

Emerging Therapeutic Ultrasound

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