Early experience of paediatric intestinal transplantation in the United Kingdom, 1993 to 1999

Beath, S. V.; Protheroe, Sue; Brook, G A; Kelly, Déirdre; McKiernan, Patrick; Murphy, Michael S.; Booth, I W; Freeman, Jonathan W.; Bennett, James; Bromley, Peter; Mayer, AD; Mirza, Darius F.; Buckels, J. A. C.; Goyet, Jean de Ville de

doi:10.1016/s0041-1345(00)01198-2

Cited by 13 publications

(7 citation statements)

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“…The waiting list death rates in this group of patients are substantially higher than those reported for any other solid organ transplant candidate group. Pretransplant mortality rates as high as 50% have been reported in the literature from individual transplant centers (31,36). While the etiology of this mortality is speculative, the advanced medical condition of these patients at the time of evaluation and the limited availability of suitably sized and quality donors no doubt contributes significantly.…”

Section: Intestine Transplantationmentioning

confidence: 99%

Liver and intestine transplantation

Roberts

Brown

Edwards

et al. 2003

American Journal of Transplantation

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Section: Intestine Transplantationmentioning

confidence: 99%

Liver and intestine transplantation

Roberts

Brown

Edwards

et al. 2003

American Journal of Transplantation

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“…These ratios have remained relatively constant. (35,36). The advanced medical condition of these patients at the time of evaluation and the limited availability of organs of suitable size and quality no doubt contribute to the high mortality rates among these patients.…”

Section: Waiting Listmentioning

confidence: 99%

Pediatric transplantation

Magee

Bucuvalas

Farmer

et al. 2004

American Journal of Transplantation

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“…United Kingdom is at present 3 years of age, 20 years ago most of the candidates were less than 2 years of age, weighing less than 10 kg and needed combined liver replacement. 8,11,12 Therefore, at this time we adopted the approach of length reduction (LR) of the intestinal graft as a life-saving option for very small transplant candidates.…”

Section: Although the Median Age For A Child Awaiting Intestinal Tran...mentioning

confidence: 99%

“…Age and size‐matched pediatric donors are extremely rare in the United Kingdom and Europe in general. Although the median age for a child awaiting intestinal transplant in the United Kingdom is at present 3 years of age, 20 years ago most of the candidates were less than 2 years of age, weighing less than 10 kg and needed combined liver replacement 8,11,12 . Therefore, at this time we adopted the approach of length reduction (LR) of the intestinal graft as a life‐saving option for very small transplant candidates.…”

Section: Introductionmentioning

confidence: 99%

Addressing extreme size mismatch in pediatric intestinal transplantation: Outcomes of intestinal length reduction

Hann

Gupte

Pathanki

et al. 2023

Pediatric Transplantation

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Background: Bench liver reduction, with or without intestinal length reduction (LR) (coupled with delayed closure and abdominal wall prostheses), has been a strategy adopted by our program for small children due to the limited availability of sizematched donors. This report describes the short, medium, and long-term outcomes of this graft reduction strategy.Methods: A single-center, retrospective analysis of children that underwent intestinal transplantation (April 1993 to December 2020) was performed. Patients were grouped according to whether they received an intestinal graft of full length (FL) or following LR.Results: Overall, 105 intestinal transplants were performed. The LR group (n = 10) was younger (14.5 months vs. 40.0 months, p = .012) and smaller (8.7 kg vs. 13.0 kg, p = .032) compared to the FL group (n = 95). Similar abdominal closure rates were achieved after LR, without any increase in abdominal compartment syndrome (1/10 vs. 7/95, p = .806). The 90-day graft and patient survival were similar (9/10, 90% vs. 83/95, 86%; p = .810). Medium and long-term graft survival at 1 year (8/10, 80% vs. 65/90, 71%; p = .599), and 5 years (5/10, 50% vs. 42/84, 50%; p = 1.00) was similar. Conclusion:LR of intestinal grafts appears to be a safe strategy for infants and small children requiring intestinal transplantation. This technique should be considered in the situation of significant size mismatch of intestine containing grafts.

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Early experience of paediatric intestinal transplantation in the United Kingdom, 1993 to 1999

Cited by 13 publications

References 0 publications

Liver and intestine transplantation

Liver and intestine transplantation

Pediatric transplantation

Addressing extreme size mismatch in pediatric intestinal transplantation: Outcomes of intestinal length reduction

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