Pediatric transplantation

Magee, John C.; Bucuvalas, John C.; Farmer, Douglas G.; Harmon, William; Hulbert-Shearon, Tempie E.; Mendeloff, Eric N.

doi:10.1111/j.1600-6143.2004.00398.x

Cited by 93 publications

(85 citation statements)

References 47 publications

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“…As previously described, pediatric deceased donors are more likely to donate each type of organ compared with adult donors (9). The percentage of pediatric deceased donors who donated specific organs was as follows: kidney 89%, liver 90%, heart 52%, pancreas 43%, lung 20% and intestine 10%.…”

Section: Pediatric Organ Donorsmentioning

confidence: 76%

Pediatric transplantation, 1994–2003

Harmon

McDonald

Reyes

et al. 2005

American Journal of Transplantation

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This article uses OPTN/SRTR data to review trends in pediatric transplantation over the last decade. In 2003, children younger than 18 made up 3% of the 82,885 candidates for organ transplantation and 7% of the 25,469 organ transplant recipients. Children accounted for 14% of the 6,455 deceased organ donors. Pediatric organ transplant recipients differ from their adult counterparts in several important aspects, including the underlying etiology of organ failure, the complexity of the surgical procedures, the pharmacokinetic properties of common immunosuppressants, the immune response following transplantation, the number and degree of comorbid conditions, and the susceptibility to post-transplant complications, especially infectious diseases. Specialized pediatric organ transplant programs have been developed to address these special problems, The transplant community has reNote on sources: The articles in this report are based on the reference tables in the 2004 OPTN/SRTR Annual Report, which are not included in this publication. Many relevant data appear in the figures and tables included here; other tables from the Annual Report that serve as the basis for this article include the following: Tables 1.4, 1.10, 1.13, 2.1-2.11, 5.1-5. 5, 5.8, 5.9, 5.11, 6.4, 7.4, 8.4, 9.1, 9.3-9.5, 9.7, 9.8, 9.11, 10.1-10.5, 10.7, 10.8, 10.11, 11.1, 11.3-11.5, 11.7, 11.8, 11.11, 12.1-12.9, 12.11, 13.1-13.4, 13.8, 13.11, 15.2 and 15.3. All of these tables may be found online at http://www.ustransplant.org. Funding: The Scientific Registry of Transplant Recipients (SRTR)is funded by contract number 231-00-0116 from the Health Resources and Services Administration (HRSA), US Department of Health and Human Services. The views expressed herein are those of the authors and not necessarily those of the US Government. This is a US Government-sponsored work. There are no restrictions on its use. sponded to the particular needs of children and has provided them special consideration in the allocation of deceased donor organs. As a result of these programs and protocols, children are now frequently the most successful recipients of organ transplantation; their outcomes following kidney, liver, and heart transplantation rank among the best. This article demonstrates that substantial improvement is needed in several areas: adolescent outcomes, outcomes following intestine transplants, and waiting list mortality among pediatric heart and lung candidates,

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Section: Pediatric Organ Donorsmentioning

confidence: 76%

Pediatric transplantation, 1994–2003

Harmon

McDonald

Reyes

et al. 2005

American Journal of Transplantation

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“…The limited number of infants under 1 year who received grafts from a deceased donor (n = 1) or living donor (n = 25) obviated the ability to include this age group in the analysis. However, the excellent long-term survival of the youngest recipients (1-5 years) of both deceased donor and living donor grafts as reported previously (10,11) justifies continued preferential allocation for the pediatric age recipient. Most disturbing is the continued poor long-term graft survival rates in the adolescent recipient, which also has been identified previously (10,11).…”

Section: Waiting Listmentioning

confidence: 90%

Pediatric Transplantation in the United States,1995–2004

Sweet

Wong

Webber

et al. 2006

American Journal of Transplantation

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This article reviews trends in pediatric solid organ transplantation over the last decade, as reflected in OPTN/SRTR data. In 2004, children younger than 18 years made up nearly 3% of the 86 378 candidates for organ transplantation and nearly 7% of the 27 031 organ transplant recipients. Children accounted for nearly 14% of the 7152 deceased organ donors. The transplant community recognizes important differences between pediatric and adult organ transplant recipients, including different etiologies of organ failure, surgical procedures that are more complex or technically challenging, effects of development on the pharmacokinetic properties of common immunosuppressants, unique immunological aspects of transplant in the developing immune system and increased susceptibility to posttransplant complications, particularly infectious diseases. For these reasons, and be- Tables 1.3, 1.4, 1.5, 1.7, 1.8, 1.10, 1.11a and b, 1.12a and b, 2.1-2.7, 5.1a, 5.3-5. 5, 5.9a-c, 5.12a, 5.12c, 5.14, 7.14, 9.1a and b, 9.3-9.5, 9.7a, 9.9a and b, 9.12a and b, 9.14, 10.1-10.7, 10.9, 10.12, 10.14, 10.15, 11.1b, 11.3-11.5, 11.9, 11.12, 11.14, 12.1-12.7, 12.9a and b, 12.14, 13.1b, 13.2, 13.4 and 15.3. All of these tables may be found online at http://www.ustransplant.org.cause of the impact of end-stage organ failure on growth and development, the transplant community has generally provided pediatric candidates with special consideration in the allocation of deceased donor organs. Outcomes following kidney, liver and heart transplantation in children often rank among the best. This article emphasizes that the prospects for solid organ transplantation in children, especially those aged 1-10 years are excellent. It also identifies themes warranting further consideration, including organ availability, adolescent survival and challenges facing pediatric transplant clinical research.

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“…It was only in 2004 that attention was drawn to the potential for DCD for cardiac transplantation in the pediatric population in a bid to reduce the unacceptably high waiting list mortality (16). The work by Gundry et al (11) formed the basis of the techniques used by the team in Denver, Colorado when embarking on their clinical programme of paediatric DCD heart transplantation (17).…”

Section: The History Of Human Dcd Heart Donationmentioning

confidence: 99%

Heart transplantation from donation after circulatory determined death

Page¹,

Messer²,

Large³

2018

Ann. Cardiothorac. Surg.

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Fifty years since the first successful human heart transplant from a non-heart beating donor, this concept of heart transplantation from donation after circulatory determined death (DCD) promises to be one of the most exciting developments in heart transplantation. Heart transplantation has established itself as the best therapeutic option for patients with end-stage heart failure, with the opportunity to provide these patients with a near-normal quality of life. However, this treatment is severely limited by the availability of suitable donor hearts. In recent times, heart transplantation has been limited to using donor hearts from donors following brain stem death. The use of donor hearts from DCD had been thought to be associated with high risk and poor outcomes until recent developments in organ perfusion and retrieval techniques have shown that this valuable resource may provide an answer to the global shortage of suitable donor hearts. With established DCD heart transplant programmes reporting encouraging results, this technique has been shown to be comparable to the current gold standard of donation after brain death (DBD) heart transplantation.

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Pediatric transplantation

Cited by 93 publications

References 47 publications

Pediatric transplantation, 1994–2003

Pediatric transplantation, 1994–2003

Pediatric Transplantation in the United States,1995–2004

Heart transplantation from donation after circulatory determined death

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